Thermally bonded composite structure degradable luminal stent and its preparation method and application

A composite structure and thermal bonding technology, applied in stents, medical science, surgery, etc., can solve the problems of stent structural integrity damage, uneven material degradation, stent collapse, etc., and achieve poor mechanical properties and bond fastness Large, the effect of improving the radial support force

Active Publication Date: 2019-09-27
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradable scaffolds prepared by these methods will all degrade in the early stage. The molecular chains of the fast-degrading components inside the material break first, resulting in uneven degradation of the material, and the structural integrity of the scaffold is quickly destroyed, resulting in the overall collapse and failure of the scaffold.

Method used

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  • Thermally bonded composite structure degradable luminal stent and its preparation method and application
  • Thermally bonded composite structure degradable luminal stent and its preparation method and application
  • Thermally bonded composite structure degradable luminal stent and its preparation method and application

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Embodiment 1

[0036] A method for preparing a thermally bonded composite structure degradable luminal stent:

[0037] Step 1: If figure 1 As shown, polycaprolactone (PCL) is used as shell yarn 2 to make four sets of yarn tubes 3 and placed on the yarn carrier 4 of the knitting machine; the yarn carrier 4 drives the yarn tubes 3 carried by it to move to implement the knitting action . The bobbin 3 carrying the PCL moves in reverse around the polydioxanone (PPDO) core yarn 5 drawn out from the through hole in the center of the track disk of the knitting machine to form the knitting yarn 1 of the shell-core structure. The PCL shell yarn is a multifilament with a diameter of 0.10mm, and the PPDO core yarn is a monofilament with a diameter of 0.30mm, and the weaving method used is 8-spindle diamond weaving;

[0038] Step 2: If figure 2 As shown, four groups of weaving yarns 1 and 20 groups of single-component degradable polymer filaments 7 of PPDO monofilaments are respectively made into bob...

Embodiment 2

[0041] A method for preparing a thermally bonded composite structure degradable luminal stent:

[0042] Step 1: If figure 1 As shown, the left-handed polylactic acid (PLLA) is used as the sheath yarn 2 to make 8 sets of yarn bobbins 3 and placed on the yarn carrier 4 of the knitting machine; the yarn carrier 4 drives the yarn bobbins 3 it carries to carry out the knitting action. The bobbin 3 carrying PLLA moves in reverse around the polyglycolide (PGA) core yarn 5 drawn out from the central through hole of the orbital disk of the knitting machine, so that the twist direction of the shell yarn 2 is positively and antisymmetrically staggered with the core yarn 5 as the central axis , forming the braided yarn 1 of the shell-core structure, the PLLA shell yarn 2 is a multifilament with a diameter of 0.05mm, and the PGA core yarn 5 is a monofilament with a diameter of 0.25mm, and the weaving method used is regular weaving with 8 spindles;

[0043] Step 2: If figure 2 As shown, ...

Embodiment 3

[0046] A method for preparing a thermally bonded composite structure degradable luminal stent:

[0047] Step 1: If figure 1 As shown, polyglycolide-lactide (PLGA) is used as shell yarn 2 to make 4 sets of bobbins 3 and place them on the yarn carrier 4 of the knitting machine; the bobbin carried by it is driven by the yarn carrier 4 to move Perform knitting. The bobbins 3 carrying PLGA are divided into two groups on average, and they move in reverse around a group of polyglycolide (PGA) core yarns 5 drawn out from the central through hole of the orbital disk of the knitting machine, so that the twist direction of the shell yarn 2 is the same as that of the core. Yarn 5 is a braided yarn 1 that is symmetrically interlaced with the central axis to form a shell-core structure. The PLGA shell yarn 2 is a multifilament with a diameter of 0.08 mm, and the PGA core yarn 5 is a monofilament with a diameter of 0.20 mm. The weaving method used is 8 Spindle diamond weaving;

[0048] St...

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Abstract

The invention discloses a degradable luminal stent with a thermal adhesive composite structure, and a preparation method thereof and application thereof as a mechanically expanded implantable woven stent against stenotic disease. The stent is made of a hollow tubular stent preforming body composed of woven yarn and degradable macromolecular silk yarn through a heat treatment process, shell yarn ismolten in the braided yarn, fusion flowing occurs at interweaving points of two groups of woven yarn, the interweaving points are bonded, and non-interweaving points of the woven yarn form the complete coating for core yarn through softening, fusion and viscose flow. The preparation method includes the steps of making the shell yarn and the core yarn into the woven yarn which is of a shell core structure, the woven yarn and the degradable macromolecular silk yarn are made into the tubular stent preforming body; and after undergoing heat treatment, the tubular stent preforming body forms the degradable luminal stent with the thermal adhesive composite structure. According to the degradable luminal stent, the interweaving points of the stent are regularly bonded and woven, so that the slippage of the interweaving points is limited, the number of the interweaving points in unit length is kept when the stent is subjected to the effect of a radial external force, and thus the radial support force of the stent is improved.

Description

technical field [0001] The invention relates to a degradable endoluminal stent with a thermally bonded composite structure and a preparation method thereof, belonging to the technical field of braided self-expanding endoluminal stents. Background technique [0002] Biodegradable stents are another revolutionary progress in the treatment of human lumen stenosis after bare metal stents and drug-eluting stents. It is a type that provides effective support for the lumen during the lesion repair period, and automatically degrades or is absorbed after the lumen heals without causing permanent damage to the human body. An ideal degradable stent can provide temporary wall support to promote the physiological repair of the damaged part, thereby preventing re-narrowing without limiting surgery or secondary interventional treatment. Due to the small inflammatory response and controllable degradation time, degradable polymer materials are currently the preferred materials for the prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L31/14A61L31/06
Inventor 王富军赵帆王璐刘来俊薛雯
Owner DONGHUA UNIV
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