Thermally bonded composite structure degradable luminal stent and its preparation method and application

Abstract

The invention discloses a degradable luminal stent with a thermal adhesive composite structure, and a preparation method thereof and application thereof as a mechanically expanded implantable woven stent against stenotic disease. The stent is made of a hollow tubular stent preforming body composed of woven yarn and degradable macromolecular silk yarn through a heat treatment process, shell yarn ismolten in the braided yarn, fusion flowing occurs at interweaving points of two groups of woven yarn, the interweaving points are bonded, and non-interweaving points of the woven yarn form the complete coating for core yarn through softening, fusion and viscose flow. The preparation method includes the steps of making the shell yarn and the core yarn into the woven yarn which is of a shell core structure, the woven yarn and the degradable macromolecular silk yarn are made into the tubular stent preforming body; and after undergoing heat treatment, the tubular stent preforming body forms the degradable luminal stent with the thermal adhesive composite structure. According to the degradable luminal stent, the interweaving points of the stent are regularly bonded and woven, so that the slippage of the interweaving points is limited, the number of the interweaving points in unit length is kept when the stent is subjected to the effect of a radial external force, and thus the radial support force of the stent is improved.

Description

technical field [0001] The invention relates to a degradable endoluminal stent with a thermally bonded composite structure and a preparation method thereof, belonging to the technical field of braided self-expanding endoluminal stents. Background technique [0002] Biodegradable stents are another revolutionary progress in the treatment of human lumen stenosis after bare metal stents and drug-eluting stents. It is a type that provides effective support for the lumen during the lesion repair period, and automatically degrades or is absorbed after the lumen heals without causing permanent damage to the human body. An ideal degradable stent can provide temporary wall support to promote the physiological repair of the damaged part, thereby preventing re-narrowing without limiting surgery or secondary interventional treatment. Due to the small inflammatory response and controllable degradation time, degradable polymer materials are currently the preferred materials for the prepa...

AI Technical Summary

Problems solved by technology

However, the degradable scaffolds prepared by these methods will all degrade in the early stage. The molecular chains of the fast-degrading components inside the material break first, resulting in uneven degradation of the material, and the structural integrity of the scaffold is quickly destroyed, resulting in the overall collapse and failure of the scaffold.

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