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Preparation method and application of capsaicin cubic liquid crystal nano-particles for promoting skin trauma healing

A skin wound and capsaicin technology, which is applied in the field of preparation of capsaicin cubic liquid crystal nanoparticles, can solve the problems of large skin irritation, enlarged wound area, slow wound healing, etc., and achieves good biocompatibility, low viscosity, and improved Effects of side effects

Inactive Publication Date: 2018-05-29
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in the prior art, there are reports in the literature that direct use of capsaicin will delay wound healing and cause skin burning pain, which may be related to changes in the local microenvironment of the wound site and the strong irritation of capsaicin
In addition, animal experiments have confirmed that direct application of capsaicin is highly irritating to the skin of rats, resulting in suppuration, redness and swelling at the injured part of the skin, larger wound area, and slower wound healing

Method used

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  • Preparation method and application of capsaicin cubic liquid crystal nano-particles for promoting skin trauma healing
  • Preparation method and application of capsaicin cubic liquid crystal nano-particles for promoting skin trauma healing
  • Preparation method and application of capsaicin cubic liquid crystal nano-particles for promoting skin trauma healing

Examples

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Effect test

Embodiment 1

[0036] A method for preparing capsaicin cubic liquid crystal nanoparticles for promoting skin wound healing, comprising the following steps:

[0037] Step 1. Put water in the container, then add F127 to dissolve and prepare the F127 solution; in this example, the concentration of F127 in the prepared F127 solution is 1%;

[0038] Step 2. Weigh a certain amount of phytantriol and capsaicin, put them in a centrifuge tube, melt and vortex in a water bath at 70°C to mix evenly, and then add dropwise to In the F127 solution prepared in step 1, a sheared sample was prepared; in this example, the mass ratio of phytantriol, capsaicin and F127 solution was 2:0.005:18; in this example, the dropping process The time of setting is 3min, and the time of described shearing is 6nin;

[0039] Step 3, transfer the sheared sample prepared in step 2 to a water bath constant temperature oscillator with a rotation speed of 100 rpm and shake for 5 hours to obtain a coarse dispersion;

[0040] Ste...

Embodiment 2

[0043] A method for preparing capsaicin cubic liquid crystal nanoparticles for promoting skin wound healing, comprising the following steps:

[0044] Step 1. Put water in the container, then add F127 to dissolve and prepare the F127 solution; in this example, the concentration of F127 in the prepared F127 solution is 0.5%;

[0045] Step 2. Weigh a certain amount of phytantriol and capsaicin, put them in a centrifuge tube, then melt and vortex in a water bath at 60°C to mix evenly, and then add dropwise to the In the F127 solution prepared in step 1, a sheared sample was prepared; in this example, the mass ratio of phytantriol, capsaicin and F127 solution was 1:0.001:15; in this example, the dropping process The time of setting is 2min, and the time of described shearing is 4min;

[0046] Step 3, transfer the sheared sample prepared in step 2 to a water bath constant temperature oscillator with a rotation speed of 50 rpm and shake for 4 hours to obtain a coarse dispersion;

[0...

Embodiment 3

[0050] A method for preparing capsaicin cubic liquid crystal nanoparticles for promoting skin wound healing, comprising the following steps:

[0051] Step 1. Put water in the container, then add F127 to dissolve and prepare the F127 solution; in this example, the concentration of F127 in the prepared F127 solution is 3%;

[0052] Step 2. Weigh a certain amount of phytantriol and capsaicin, put them in a centrifuge tube, melt and vortex in a water bath at 80°C to mix evenly, and then add dropwise to In the F127 solution prepared in step 1, a sheared sample was prepared; in this example, the mass ratio of phytantriol, capsaicin and F127 solution was 3:0.05:20; in this example, the dropping process The time of setting is 5min, and the time of described shearing is 8nin;

[0053] Step 3, transfer the sheared sample prepared in step 2 to a water bath constant temperature oscillator with a rotation speed of 150rpm and shake for 6h to obtain a coarse dispersion;

[0054] Step 4. Pu...

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Abstract

The invention relates to the technical field of medicinal preparations, in particular to a preparation method and the application of capsaicin cubic liquid crystal nano-particles for promoting skin trauma healing. The preparation method of the capsaicin cubic liquid crystal nano-particles comprises the following steps: firstly, preparing an F127 solution; secondly, thawing, whirling and uniformlymixing phytantriol and capsaicin on a water bath, and then adding the mixed solution into the F127 solution under the shearing of a homogenizer; thirdly, oscillating in a constant-temperature oscillator in the water bath to prepare course dispersoid; fourthly, performing ultrasonic crushing on the course dispersoid in an ultrasonic cell crushing machine to prepare the capsaicin cubic liquid crystal nano-particles. The capsaicin cubic liquid crystal nano-particles prepared by the preparation method can obviously reduce the pungency of the capsaicin and has a good trauma healing promoting effect. Moreover, the capsaicin cubic liquid crystal nano-particles prepared by the invention can be applied to a medicinal preparation for promoting the skin trauma healing.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method and application of capsaicin cubic liquid crystal nanoparticles for promoting skin wound healing. Background technique [0002] Skin wound healing has always been a research hotspot in skin and plastic surgery at home and abroad. Skin wound healing is a complex biological process, including three stages of inflammatory response, cell proliferation, wound maturation and reconstruction. Among them, the inflammatory response phase: inflammatory factors such as TNF-a can induce inflammatory cells, fibroblasts and keratinocytes to migrate to the wound site and start wound repair. Cell proliferation: Migration and proliferation of fibroblasts, epidermal keratinocytes, and endothelial cells promote wound re-epithelialization, neovascularization, formation of granulation tissue, and recovery of skin barrier function. Fibroblasts are the main eff...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/165A61K47/10A61P17/02
CPCA61K9/5146A61K9/5123A61K31/165
Inventor 彭新生周艳星周志昆周艳芳李宝红王勤于琼刘雯恩范志强
Owner GUANGDONG MEDICAL UNIV
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