Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of high-dispersity nano-apatite

A high-dispersion, apatite technology, applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of low solubility of phosphorylated cyclodextrin, increase of experimental cost, environmental pollution, etc., and achieve good interface combination performance, short response time, and the effect of expanding the application range

Active Publication Date: 2018-05-29
HUNAN NORMAL UNIVERSITY
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the phosphorylated cyclodextrin used has low solubility in water and needs to be dissolved in organic solvents such as N,N-dimethylformamide, N,N-dimethylacetamide, and dimethyl sulfoxide. Increased costs and pollution to the environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of high-dispersity nano-apatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Dissolve 17.36 g of carboxylated β-cyclodextrin in 200 ml of water, add 8.86 g of calcium nitrate tetrahydrate and dissolve in 100 ml of water, stir for 3 hours, then add 8.55 g of sodium phosphate dodecahydrate and dissolve in 100 ml of water ml of water, slowly add it dropwise to the above solution, adjust the pH value to about 10 with 10 wt% sodium hydroxide, heat and stir at 70 °C for 4 hours, let stand for 48 hours, wash 5 times with deionized water, and then wash with ethanol Wash 3 times and dry for later use.

Embodiment 2

[0017] Example 2: Dissolve 5.79 g of carboxylated β-cyclodextrin in 300 ml of water, add 26.58 g of calcium nitrate tetrahydrate and dissolve in 300 ml of water, stir for 2 hours, then add 25.63 g of sodium phosphate dodecahydrate and dissolve in 150 ml of water ml of water, slowly add it dropwise to the above solution, adjust the pH value to about 12 with 15 wt% sodium hydroxide, heat and stir at 80°C for 6 hours, let it stand for 48 hours, wash 5 times with deionized water, and then wash with ethanol Wash 3 times and dry for later use.

Embodiment 3

[0018] Example 3: Dissolve 7.74 g of carboxylated α-cyclodextrin in 100 ml of water, add and dissolve 17.70 g of calcium nitrate tetrahydrate in 200 ml of water, stir for 3 hours, then add 17.07 g of sodium phosphate dodecahydrate and dissolve in 50 ml of water was slowly added dropwise to the above solution, the pH was adjusted to about 10 with 10 wt% sodium hydroxide, heated and stirred at 60 °C for 4 hours, after standing for 48 hours, washed 5 times with deionized water, and then used Washed 3 times with ethanol and dried for later use.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of high-dispersity nano-apatite. The high-dispersity nano-apatite is prepared through the following steps: reacting carboxylate cyclodextrin with calcium salt, adding inorganic phosphorous source, regulating pH value to about 10, heating and stirring to react for 3-6 hours at 30-90 DEG C, standing overnight, pouring the supernatant liquid, washing untilthe pH value is about 7, and washing for 2-3 times by using absolute ethyl alcohol thereby preparing the high-dispersity nano-apatite. The nano-apatite prepared through the preparation method disclosed by the invention not only has good dispersity in the hydrophilic solvent, but also can maintain high dispersity in a hydrophobic solution such as dichloromethane, so that the nano-apatite is expected to compound with different polymers in a high content so as to manufacture composite material with high bone conduction to be used as the orthopedics material.

Description

technical field [0001] The invention relates to a preparation method of highly dispersed nano-apatite, which belongs to the field of biomedical materials. Background technique [0002] Synthetic nano-hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , n-HA], because its composition and structure are similar to the inorganic components of human bone, it is often used as a polymer filler to endow the polymer with osteoconductivity and exert its nano-reinforcement effect, so as to obtain an ideal composite material for Most orthopedic materials such as bone repair, fracture, intervertebral fusion, etc., have become the focus of research in orthopedic materials. However, studies have shown that n-HA inorganic nanoparticles are difficult to disperse in hydrophobic solvents due to their inherent agglomeration characteristics, especially their surface hydrophilicity, making it difficult to compound with hydrophobic polymers. Difficulties that need to be solved urgently in the research. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C01B25/32C08K3/32A61L27/12A61L27/20A61K47/02A61K47/40B82Y30/00
CPCA61K47/02A61K47/40A61L27/12A61L27/20B82Y30/00C01B25/325C08K3/32A61L2430/02C08K2003/325C01P2002/72C08L5/16
Inventor 蒋柳云丁豪杰马兵利苏胜培
Owner HUNAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com