Vascular dementia model of influence of hemopoietin on choline acetyl transferase

A technology for erythropoietin and vascular dementia, which is applied to medical preparations containing active ingredients, organic active ingredients, active ingredients of hydroxyl compounds, etc. It has the advantages of low cost of preparation, protection of ischemic brain tissue, and long-lasting drug effect.

Inactive Publication Date: 2018-06-01
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cons: Recoverable, not permanent damage
Disadvantages: Although this experimental model is very commonly used and effectively simulates its pathological characteristics, it is still different from the characteristics in the natural state, causing certain physical damage to the animal, and it is difficult to grasp the cut site, which may cause other Nerve cells in the site can also cause damage, which has high requirements on the technique of the experimenter, and it is basically not used at present.
The disadvantage is that most of the transgenic animal

Method used

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  • Vascular dementia model of influence of hemopoietin on choline acetyl transferase
  • Vascular dementia model of influence of hemopoietin on choline acetyl transferase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] The pharmaceutical composition for the treatment of dementia consists of

[0110] 5 parts of seabuckthorn, 4 parts of Yizhi kernel, 3 parts of lotus seeds, 50 parts of Smilax cocos, 20-90 parts of malt, 30-80 parts of calcined oyster, 0-1 part of β-asarone, 0-3 parts of Panax notoginseng saponins , 3 parts of icariin and 2 parts of polydatin with a purity greater than 95%.

Embodiment 2

[0112] The pharmaceutical composition for the treatment of dementia consists of

[0113] 120 parts of seabuckthorn, 100 parts of Yizhi kernel, 120 parts of lotus seeds, 120 parts of Smilax cocos, 20-90 parts of malt, 30-80 parts of calcined oyster, 0.1 part of muscone, 3 parts of Panax notoginseng saponins, 3 parts of icariin composition.

Embodiment 3

[0115] The pharmaceutical composition for the treatment of dementia consists of

[0116] 60 parts of sea buckthorn, 55 parts of Yizhi kernel, 60 parts of lotus seeds, 50-120 parts of Smilax cocos, 20-90 parts of malt, 30-80 parts of calcined oyster, 0-0.1 parts of muscone, 0-1 part of β-asarone , 0-3 parts of icariin and 1 part of polydatin with a purity greater than 95%.

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Abstract

The invention belongs to the technical field of bioassay, and discloses a vascular dementia model of the influence of hemopoietin on choline acetyl transferase. A big mouse not showing the symptom ofthe lesion of the vascular dementia model is subjected to water deprivation and is allowed to continuously and naturally drink a 1%-4% methyl alcohol aqueous solution for 60-240 days, or banana tasteflavouring agent capable of making the big mouse generate preference is further dissolved in the methyl alcohol aqueous solution, the methyl alcohol intake of the big mouse per day is controlled at 1mg/ kg to 2 mg/ kg, and the vascular dementia model capable of showing the influence of hemopoietin on choline acetyl transferase can be obtained; after the vascular dementia model the influence of hemopoietin on choline acetyl transferase is obtained, the dementia type disorder and the like are evaluated. The acting mechanism of ChAT in EPO for improving the VaD big mouse recognition disorder isdetermined.

Description

technical field [0001] The invention belongs to the technical field of biological testing, in particular to a vascular dementia model of the influence of erythropoietin on choline acetyltransferase. Background technique [0002] Currently, vascular dementia (VaD) is an important cause of senile dementia. Studies have shown that in addition to pathological changes in brain structure during the occurrence of dementia, the metabolism of neurotransmitters and enzymes (such as acetylcholine (Ach) and choline acetyltransferase (Ch AT) related to the process of learning and memory in the brain are also affected. An exception occurs. ChAT is considered to be an enzyme that promotes the metabolism of the neurotransmitter ACh in the brain related to learning and memory, and its content in memory-related brain regions is positively correlated with learning and memory abilities. In recent years, foreign studies have found that the secretion of erythropoietin (EPO) in the central nervo...

Claims

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Application Information

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IPC IPC(8): A01K67/02A61K31/045A61K49/00A61K36/9062A61P25/28A61K31/7034A61K31/09A61K31/122A61K31/7048A61K35/618
CPCA01K67/02A01K2207/20A01K2227/105A01K2267/0312A61K31/045A61K31/09A61K31/122A61K31/7034A61K31/7048A61K35/618A61K36/185A61K36/258A61K36/62A61K36/896A61K36/8998A61K36/90A61K36/9062A61K49/0008A61K2300/00
Inventor 黄树其
Owner SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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