Method for producing hollow porous microspheres

A technique for porous microspheres and a manufacturing method, which is applied in the field of scaffolds for tissue engineering in biological tissues, which can solve the problems of reduced production efficiency, low pore uniformity, and high loss rate, and achieve simplified production processes and excellent stomatal uniformity Effect

Active Publication Date: 2018-06-08
PHARMARES PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, since the specific gravity of the produced fine particles is heavier than that of water, there is a disadvantage that an additional filtration process is required to obtain the precipitated fine particles
In addition, due to the complex manufacturing process and many inhibitory factors, the production is completed through a batch reaction process, so there are problems in that the production efficiency is reduced, the uniformity of the pores formed in the microspheres is low, the loss rate in the process is high, and industrial application is difficult.

Method used

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  • Method for producing hollow porous microspheres
  • Method for producing hollow porous microspheres
  • Method for producing hollow porous microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] [Example 1] Production of hollow porous microspheres 1

[0042] Hollow porous microspheres according to an embodiment of the present invention have been manufactured by the following method (refer to figure 1 ).

[0043] Step 1: Fabrication of a simple fluidic device

[0044] A 30-gauge injection needle bent at 90° was placed in a PVC tube, and a microfluidic device was fabricated by inserting a fine glass tube between the injection needle and the PVC tube. The fabricated microfluidic device uses epoxy adhesive to plug the tiny gaps.

[0045] Step 2: Preparation of PLLA solution containing alkanes

[0046] 0.1 g of PLLA (RESOMER LR 704S, Evonik Industries AG) as a hydrophobic biodegradable polymer, 10 g of dichloromethane (Dichloromethane; 34355-0350, Junsei) as a volatile solvent, and alkanes as a stomatal formation inducing substance Substances, specifically octane (Octane, 412236, Sigma-aldrich) or undecane (U407, Sigma-aldrich) or tridecane (T57401, Sigma-aldric...

Embodiment 2

[0054] [Example 2] Production of hollow porous microspheres 2

[0055] Hollow porous microspheres according to an example of the present invention were manufactured by the following method.

[0056] Step 1: Fabrication of a simple fluidic device

[0057] A 30-gauge injection needle bent at 90° was placed in a PVC tube, and a microfluidic device was fabricated by inserting a fine glass tube between the injection needle and the PVC tube. The fabricated microfluidic device uses epoxy adhesive to plug the tiny gaps.

[0058] Step 2: Manufacture of PLLA solution containing vegetable oil

[0059] Mix 0.1 g of PLLA (RESOMER LR 704S, Evonik Industries AG) as a hydrophobic biodegradable polymer, 10 g of methylene chloride (34355-0350, Junsei), and 0.5 g each of cottonseed oil or soybean oil as a stomatal formation inducing substance , thus making a hydrophobic biodegradable polymer (PLLA) solution.

[0060] Step 3: Create a uniform PLLA emulsion

[0061] Use the PLLA solution obta...

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Abstract

The present invention provides a method for producing hollow porous microspheres, comprising: a polymer solution production step which comprises dissolving a substance for inducing pore formation anda hydrophobic biodegradable polymer in a volatile solvent; a step for forming an oil-in-water (O/W) emulsion by dispersing the resulting polymer solution in an aqueous solution comprising water or a phase stabilizer; a hollow porous microsphere production step which comprises volatilizing the volatile solvent in the aqueous solution having the polymer solution dispersed therein so as to solidify the hydrophobic biodegradable polymer and causing voluntary phase separation between the hydrophobic biodegradable polymer and the substance for inducing pore formation so as to change an oil-phase polymer solution comprised in the oil-in-water (O/W) emulsion to oil-in-solid (O/S) microspheres; and a step for removing the substance for inducing pore formation comprised in the hollow porous microspheres.

Description

technical field [0001] The present invention relates to a method for producing a scaffold for tissue engineering that can be delivered into living tissue such as skin tissue. Background technique [0002] In medical devices for cosmetic surgery sold for the purpose of cosmetic surgery, fillers are used to inject skin tissue into wrinkles and depressions. Most of the fillers are injected into the skin tissue and increase the volume of the skin tissue by the volume of the substance itself to improve skin wrinkles or depressions. Currently, the most widely used fillers are hyaluronic acid and collagen, which are in the form of gels without a fixed shape. However, there is a problem that the effect of cosmetic surgery will not be maintained for a long time because it is absorbed into the skin tissue over time. [0003] In addition, as a medical device for cosmetic surgery, in order to have a wide range of use, it needs to be delivered by injection, but the porous material that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/14C08L101/16
CPCA61L27/14C08L101/16
Inventor 金赫阿泳昌崔星旭文昇官朴元锡
Owner PHARMARES PROD
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