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Preparation method of multifunctional hemostatic antibacterial and anti-Inflammatory toothpaste, product and application thereof

A hemostatic, antibacterial and multi-functional technology is applied in the production of multi-functional hemostatic, antibacterial and anti-inflammatory toothpaste, the preparation of multi-functional hemostatic, antibacterial and anti-inflammatory toothpaste, and the field of mesoporous silica surface modification of chitosan, which can solve problems such as tissue thermal burns. To achieve rapid hemostasis, strong operability, and the effect of satisfying production and application

Active Publication Date: 2018-06-12
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Quickclot TM There is a significant exothermic reaction during the use of hemostatic agents, which may even cause tissue thermal burns in severe cases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of surface-modified mesoporous silica

[0032] A certain amount of surfactant was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of CTAB to TEOS is 0.1:1. At the same time 0.1 mmol APTES. The reactant was slowly stirred at 25°C for 10 hours, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, refluxed in toluene solution for 12 hours, and vacuum-dried at 80°C for 12 hours.

[0033] (2) Surface grafted chitosan

[0034] Dissolve chitosan with a deacetylation degree of 95% in 1% acetic acid solution, stir slowly at room temperature for 0.5 hours, then add surface-modified mesoporous silica, the mass ratio of chitosan to mesoporous silica is 1:1. After adjusting the pH of the system to 5, stir slowly for 0.5 hours, add EDC and NHS with a mass concentration of 1% respectively, stir and react...

Embodiment 2

[0045](1) Preparation of surface-modified mesoporous silica

[0046] A certain amount of surfactant was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of Triton X-100 to TEOS is 0.15:1. At the same time 0.5 mmol APTES. The reactant was slowly stirred at 25°C for 10 hours, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, refluxed in toluene solution for 12 hours, and vacuum-dried at 80°C for 12 hours.

[0047] (2) Surface grafted chitosan

[0048] Dissolve chitosan with a deacetylation degree of 75% in 1% acetic acid solution, stir slowly at room temperature for 0.5 hours, then add surface-modified mesoporous silica, the mass ratio of chitosan to mesoporous silica is 1:1.5. After adjusting the pH of the system to 9, stir slowly for 0.5 hours, add EDC and NHS with a mass concentration of 1% respectively, stir...

Embodiment 3

[0059] (1) Preparation of surface-modified mesoporous silica

[0060] A certain amount of polyoxyethylene lauryl ether was dissolved in 180 mL of water, and after stirring for 15 minutes, 6 mmol of NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of polyoxyethylene lauryl ether to TEOS is 0.2:1. Simultaneously 1 mmol APTES. The reactant was slowly stirred at 25°C for 10 hours, and the obtained reaction product was aged at room temperature for 12 hours, washed with twice distilled water, refluxed in toluene solution for 12 hours, and vacuum-dried at 80°C for 12 hours.

[0061] (2) Surface grafted chitosan

[0062] Dissolve chitosan with a deacetylation degree of 75% in 1% acetic acid solution, stir slowly at room temperature for 0.5 hours, then add surface-modified mesoporous silica, the mass ratio of chitosan to mesoporous silica is 1:2. After adjusting the pH of the system to 9, stir slowly for 0.5 hours, add EDC and NHS with a mass concent...

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PUM

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Abstract

The invention relates to a preparation method of multifunctional hemostatic antibacterial and anti-Inflammatory toothpaste, a product and application thereof. The preparation process of the multifunctional hemostatic antibacterial and anti-inflammatory toothpaste is characterized by comprising the following steps of: firstly preparing surface-modified mesoporous silicon dioxide, then grafting chitosan molecules on the surface of the mesoporous silicon dioxide to obtain an inorganic / organic hybrid nano material, adopting the inorganic / organic hybrid nano material to adsorb natural plant extract, adopting a product obtained as an abrasive to prepare the antibacterial toothpaste. The preparation method, the product and the application have the advantages that the mesoporous silicon dioxide isadopted as a medium to realize the fast-hemostasis effect; the chitosan molecules are modified on the surface of the mesoporous silicon dioxide to realize the antibacterial effect; the natural plantextract is adsorbed in mesoporous channels to realize the anti-inflammatory effect. The multifunctional toothpaste prepared by utilizing the multifunctional abrasive integrates the hemostatic function, the antibacterial function and the anti-inflammatory function; the preparation method disclosed by the invention is simple in process and strong in operability and can further meet production and application.

Description

technical field [0001] The present invention relates to the field of preparation of polymer materials, and relates to a preparation method of a multifunctional hemostatic, antibacterial and anti-inflammatory toothpaste and its products and applications, in particular to a mesoporous silica surface modified chitosan, which is used in many The production of functional hemostatic antibacterial and anti-inflammatory toothpaste. Background technique [0002] Toothpaste is one of the commonly used oral products. Its functions mainly include two parts. One is to remove bad breath and peculiar smell, antibacterial and anti-inflammatory, so as to make breath fresh and refreshing. At present, natural plant toothpaste is a class of toothpaste that contains natural plant extracts and has effects such as anti-inflammatory, deodorant, and pain relief. Among them, the hemostatic toothpaste achieves blood coagulation by adding functional organic substances (such as traditional Chinese medi...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9794A61K8/73A61K8/25A61Q11/00A61P31/02A61P29/00A61P7/04A61P1/02
CPCA61K8/25A61K8/736A61K8/97A61K2800/28A61K2800/84A61Q11/00
Inventor 何丹农朱君刘睿王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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