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Externally-applied cream composition containing luliconazole

A technology of luliconazole and topical cream, applied in the field of medicine, can solve the problems of patients' mental pain, affect beauty and social interaction, etc.

Inactive Publication Date: 2018-06-12
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although vitiligo has no subjective symptoms, it causes great mental pain to patients and seriously affects beauty and social interaction.

Method used

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  • Externally-applied cream composition containing luliconazole
  • Externally-applied cream composition containing luliconazole
  • Externally-applied cream composition containing luliconazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Embodiment 1 Luliconazole cream preparation (unit: g)

[0145]

[0146]

[0147] Preparation Process:

[0148] Step 1: take the luliconazole raw material drug and ultrafinely pulverize it, with an average particle size of less than 20 μm, and set it aside;

[0149] Step 2: Take propylene glycol as the oil phase solvent, heat it in a water bath to 60°C, take the prescribed amount of antioxidant vitamin E, luliconazole, eucalyptol as a transdermal enhancer, stearyl alcohol as a thickener, and monostearyl as an emulsifier Acid glyceride is stirred and dissolved to form an oil phase;

[0150] Step 3: Take the water phase solvent, heat it in a water bath to 60°C, stir to dissolve the emulsifier polysorbate 80, adjust the pH value to 6.0-7.0 with 0.1M NaOH or HCl, and form the water phase;

[0151] Step 4: Add the water phase to the oil phase under vacuum, lower the temperature, and continue stirring until the temperature of the system drops to room temperature to obt...

Embodiment 2

[0153] Example 2 Luliconazole liposome cream preparation

[0154] Prescription composition:

[0155]

[0156]

[0157] The preparation steps are as follows:

[0158] Step 1: take the luliconazole raw material drug and ultrafinely pulverize it, with an average particle size of less than 20 μm, and set it aside;

[0159] Step 2: Take propylene glycol as the oil phase solvent, heat it in a water bath to 60°C, take the prescription amount of stearyl alcohol as a thickener, and glyceryl monostearate as an emulsifier, stir, dissolve, and form an oil phase;

[0160] Step 3: Take the water phase solvent, heat it in a water bath to 60°C, stir to dissolve the emulsifier polysorbate 80, adjust the pH value to 6.0-7.0 with 0.1M NaOH or HCl, and form the water phase;

[0161] Step 4: In a vacuum state, add the water phase to the oil phase, lower the temperature, and continue to stir until the system temperature drops to room temperature to obtain a blank cream base;

[0162] Step ...

Embodiment 3

[0166] Example 3 Preparation of luliconazole elastosome cream

[0167] Prescription composition:

[0168]

[0169] The preparation steps are as follows:

[0170] Step 1: take the luliconazole raw material drug and ultrafinely pulverize it, with an average particle size of less than 20 μm, and set it aside;

[0171] Step 2: Take the prescription amount of stearyl alcohol as a thickener and glyceryl monostearate as an emulsifier in turn, heat in a water bath to 60°C, stir, dissolve, and form an oil phase;

[0172] Step 3: Take the water phase solvent, heat it in a water bath to 60°C, stir to dissolve the emulsifier polysorbate 80, adjust the pH value to 6.0-7.0 with 0.1M NaOH or HCl, and form the water phase;

[0173] Step 4: In a vacuum state, add the water phase to the oil phase, lower the temperature, and continue to stir until the system temperature drops to room temperature to obtain a blank cream base;

[0174] Step 5: Dissolve the prescription amount of soybean leci...

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Abstract

The invention relates to an externally-applied cream composition containing luliconazole. Aiming at the defect that the luliconazole raw material is easily oxidized and degraded, a manner of adding anantioxidant into an externally-applied cream preparation system is adopted to avoid the occurrence of oxidization reaction; a skin penetration enhancer is added and the techniques of liposomes and ethosomes are adopted to improve the skin penetration performance of the externally-applied preparation containing luliconazole; the treatment effect of the medicine is enhanced. Tests prove that various detection indexes of the prepared cream meet the standards; meanwhile, the generation of oxidized and degraded impurities are obviously inhibited; the stability of the product is greatly improved; the skin penetration enhancer is added and the techniques of liposomes and ethosomes are adopted, so that the skin penetration performance of the cream is improved; the original purpose is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an external use cream composition containing luliconazole and a preparation method and application thereof. Background technique [0002] Fungal skin diseases are the result of fungal infection of the skin tissue site. The fungal infection can be distributed in the skin of the whole body, the highest incidence is the stratum corneum, and its typical symptoms are ringworm, candida infection and vitiligo. According to the survey, patients with dermatophyte infection accounted for about 13% of outpatients in dermatology, including 88.0% of tinea patients, 8.5% of candidiasis patients and 3.4% of vitiligo patients, and 64.0% of tinea pedis patients were tinea pedis. . [0003] Ringworm is a refractory skin disease with a slow course of disease and a high recurrence rate after treatment. The inflammation is obvious at the onset, and there are skin lesions such as bliste...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/127A61K31/4178A61K47/22A61P17/00A61P31/10
CPCA61K31/4178A61K9/06A61K9/1271A61K47/22
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司
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