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Cefteram pivoxil tablets and preparation method and application thereof

A technology for cefdram pivoxil and cefdram, which is applied in the field of cefdram pivalate tablets and their preparation, can solve the problems that the quality stability of the preparation needs to be improved and the impurity content is high, achieves good spatial scale effect, improves the Quality stability, the effect of reducing the generation of degraded impurities

Active Publication Date: 2018-06-12
清远华能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cefditoren neopentyl tablet uses croscarmellose sodium and microcrystalline cellulose to improve the disintegration time limit and release effect of the tablet, but the impurity content is a bit high, and the quality stability of the preparation needs to be improved. improve

Method used

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  • Cefteram pivoxil tablets and preparation method and application thereof
  • Cefteram pivoxil tablets and preparation method and application thereof
  • Cefteram pivoxil tablets and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1 Cefditoren Neopentyl Proxil Tablets

[0029] The cefditoren neopentyl tablet comprises the following components and their mass parts: 40 parts of cefditoren neopentyl micropowder, 10 parts of cefditoren neopentyl superfine powder, 22 parts of starch, 10 parts of lactose, and a disintegrant 12 parts, 3 parts of hydroxypropyl cellulose, 0.5 parts of magnesium stearate, 2.5 parts of gastric-soluble coating material; The particle size of the ultrafine ester powder is 3-6 μm. The disintegrating agent is composed of microcrystalline cellulose and mannitol in a mass ratio of 3:1; the gastric-soluble coating material is composed of hydroxypropyl methylcellulose, polyoxyethylene (105) polyoxypropylene (5) sugar , titanium dioxide, yellow No. 6 sunset yellow and carnauba wax are made according to the mass ratio of 4-8:1-3:0.1-0.5:0.05-0.2:0.1-0.5.

[0030] The preparation method of cefditoren neopentyl tablet comprises the steps:

[0031] S1 Mix cefditoren neopent...

Embodiment 2

[0034] Embodiment Two Cefditoren Neopentyl Proxil Tablets

[0035]Cefditoren Neopentyl Exil Tablets, comprising the following components and their parts by mass: 42 parts of cefditoren neopentyl pivoxil micropowder, 8 parts of cefditoren neopentyl pivoxil superfine powder, 20 parts of starch, 10 parts of lactose, disintegrant 15 parts, 2 parts of hydroxypropyl cellulose, 0.5 parts of magnesium stearate, 2.5 parts of gastric-soluble coating materials; The particle size of the ultrafine ester powder is 3-6 μm. The disintegrating agent is composed of microcrystalline cellulose and mannitol in a mass ratio of 4:1; the gastric-soluble coating material is a commercially available acrylic resin gastric-soluble coating material.

[0036] The preparation method of cefditoren neopentyl tablet comprises the steps:

[0037] S1 Mix cefditoren neopentyl pivoxil micropowder, cefditoren neopentyl pivoxil superfine powder, starch, lactose and disintegrant evenly, add soft material made of hy...

Embodiment 3

[0040] Embodiment Three Cefditoren Neopentyl Axil Tablets

[0041] Cefditoren Neopentyl Exil Tablets, comprising the following components and their parts by mass: 38 parts of cefditoren neopentyl pivoxil micropowder, 12 parts of cefditoren neopentyl pivoxil superfine powder, 18 parts of starch, 10 parts of lactose, disintegrant 14 parts, 3 parts of hydroxypropyl cellulose, 0.5 parts of magnesium stearate, 2.5 parts of gastric-soluble coating materials; The particle size of the ultrafine ester powder is 3-6 μm. The disintegrating agent is composed of microcrystalline cellulose and mannitol in a mass ratio of 3:1; the gastric-soluble coating material is composed of hydroxypropyl methylcellulose, polyoxyethylene (105) polyoxypropylene (5) sugar , titanium dioxide, yellow No. 6 sunset yellow and carnauba wax are made according to the mass ratio of 4-8:1-3:0.1-0.5:0.05-0.2:0.1-0.5.

[0042] The preparation method of cefditoren neopentyl tablet comprises the steps:

[0043] S1 Mi...

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Abstract

The invention belongs to the technical field of medicinal preparations and provides cefteram pivoxil tablets which comprise, by mass, 36-45 parts of cefteram pivoxil micropowder, 6-12 parts of cefteram pivoxil ultrafine powder, 10-30 parts of starch, 5-20 parts of lactose, 6-18 parts of disintegrant, 2-5 parts of hydroxypropyl cellulose, 0.25-2 parts of magnesium stearate and 1-4 parts of gastric-soluble coating material. Grain size of the cefteram pivoxil micropowder is 35-50um, and grain size of the cefteram pivoxil ultrafine powder is 3-6um. The cefteram pivoxil tablets can promote dissolution of cefteram pivoxil, enhance adhesiveness with small intestinal mucosa, increase bioavailability, improve quality stability of preparations and reduce degraded impurities.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a cefditoren neopentyl tablet and a preparation method and application thereof. Background technique [0002] Cefditoren Neopentyl Proxil, also known as Cefditoren Proxil, is a third-generation cephalosporin antibiotic developed and marketed by Japan Toyama Chemical Co., Ltd. Its molecular formula is C22H27N9O7S2, its molecular weight is 593.64, and its structural formula is as follows: [0003] [0004] Cefditoren neopentyl has antibacterial effect on Gram-positive bacteria and Gram-negative bacteria. Bactericidal effect. Cefditoren neopentyl is stable to β-lactamase produced by various bacteria, so it is also effective for β-lactamase-producing strains. Clinically, cefditoren neopentyl is mainly used to treat respiratory infections caused by sensitive bacteria, such as pharyngitis, tonsillitis and acute and chronic bronchitis; it can also be used to tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/546A61K47/38A61K47/36A61K47/26A61P31/04
CPCA61K9/2018A61K9/2054A61K9/2059A61K9/2866A61K31/546
Inventor 黄劲松刘瑛何梅欧文星
Owner 清远华能制药有限公司