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A di -hydrogen bayonin pharmaceutical and preparation method based on TWEEN80 and chitosan as the carrier

A technology of dihydromyricetin and chitosan, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor solubility and limit practical application, and achieve improved solubility Effect

Active Publication Date: 2021-01-08
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are hydrophilic and hydrophobic groups in the structure of chitosan, which has a certain self-aggregation ability, but the poor solubility of chitosan limits its practical application

Method used

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  • A di -hydrogen bayonin pharmaceutical and preparation method based on TWEEN80 and chitosan as the carrier
  • A di -hydrogen bayonin pharmaceutical and preparation method based on TWEEN80 and chitosan as the carrier
  • A di -hydrogen bayonin pharmaceutical and preparation method based on TWEEN80 and chitosan as the carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Surfactant / oil / water ratio is 44 / 11 / 45, and chitosan mass fraction is 4%, weighs Tween 80 and WCS (as surfactant) and places in colorimetric tube, mixes and makes chitosan Disperse evenly in Tween 80. IPM was added thereto, and stirred and mixed evenly under a water bath at 65°C. Finally, add double-distilled water dropwise to the colorimetric tube, the water content increases at intervals of 2%, stir evenly with a magnetic stirrer, then place it in a water bath at 25°C to balance, observe and record the phase state and appearance of the aggregate The change of the aggregate needs to prolong the equilibrium time of the aggregate when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, hardness, viscosity, etc. of the aggregates. denoted as S 1

Embodiment 2

[0052] Surfactant / oil / water ratio is 44 / 11 / 45, and chitosan mass fraction is 8%, weighs Tween 80 and WCS (as surfactant) and places in colorimetric tube, mixes and makes chitosan Disperse evenly in Tween 80. IPM was added thereto, and stirred and mixed evenly under a water bath at 65°C. Finally, add double-distilled water dropwise to the colorimetric tube, the water content increases at intervals of 2%, stir evenly with a magnetic stirrer, then place it in a water bath at 25°C to balance, observe and record the phase state and appearance of the aggregate The change of the aggregate needs to prolong the equilibrium time of the aggregate when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, hardness, viscosity, etc. of the aggregates. denoted as S 2 .

Embodiment 3

[0056] The ratio of surfactant to oil is 9:1, the mass fraction of chitosan is 4.5%, and the water content is 45%. Weigh Tween80 and WCS (as surfactant) and place them in colorimetric tubes, mix well to make the shell Glycans are evenly dispersed in Tween 80. IPM was added thereto, and stirred and mixed evenly under a water bath at 65°C. Finally, add double-distilled water dropwise to the colorimetric tube, the water content increases at intervals of 2%, stir evenly with a magnetic stirrer, then place it in a water bath at 25°C to balance, observe and record the phase state and appearance of the aggregate The change of the aggregate needs to prolong the equilibrium time of the aggregate when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, hardness, viscosity, etc. of the aggregates. denoted as S 1 o 2 .

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Abstract

The invention relates to dihydromyricetin medicament with a carrier which is aggregate on the basis of polyoxyethylene sorbitan monooleate and chitosan and a method for preparing the dihydromyricetinmedicament. The dihydromyricetin medicament comprises dihydromyricetin, the polyoxyethylene sorbitan monooleate, the chitosan, isopropyl myristate and water. The dihydromyricetin medicament and the method have the advantages that sample types are characterized by the aid of phase diagram processes and small-angle X ray diffraction, influence of the content of the chitosan, the content of oil, thecontent of the water and pH (potential of hydrogen) values of systems on release of the dihydromyricetin can be obtained, the chitosan can be dissolved in the systems and forms the stable aggregate, various components in the prepared dihydromyricetin medicament coordinate with one another and are matched with one another, and accordingly effects of controlling the release speed of the dihydromyricetin medicament can be realized; fitting can be carried out on release curves by the aid of different release kinetic models, the fact that release procedures conform to first-order kinetics is discovered, and accordingly the fact that the dihydromyricetin is released in samples under the effect of concentration diffusion is illustrated.

Description

technical field [0001] The invention belongs to the technical field of medicament preparation, and in particular relates to a dihydromyricetin medicament based on an aggregate of Tween80 and chitosan as a carrier and a preparation method thereof. Background technique [0002] Dihydromyricetin (DMY) is a natural flavonoid compound extracted from plants. It has attracted widespread attention due to its many physiological activities, such as protecting the liver, regulating blood lipids, antibacterial, and antioxidant. However, its poor solubility in water (0.2 mg / mL, 25°C) leads to low bioavailability, which greatly limits its practical application. In recent years, in order to improve the above problems of DMY, DMY has been entrapped by drug carriers such as microemulsions, liposomes, micelles, etc. in recent years, solubilizing drugs to improve the solubility of DMY has become a research hotspot. [0003] Surfactants are a class of amphiphilic organic compounds with both a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/26A61K47/14A61K47/04A61K31/352A61P1/16A61P3/06A61P31/04A61P31/10A61P39/06
CPCA61K31/352A61K47/02A61K47/14A61K47/26A61K47/36
Inventor 王仲妮董爽爽
Owner SHANDONG NORMAL UNIV
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