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Preparation method of 3D printing material for bone repairing stent

A 3D printing and bone repair technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of limited application and achieve the effect of promoting bone regeneration, good mechanical properties and structural stability

Inactive Publication Date: 2018-06-15
许宏军 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Materials currently used for bone tissue repair include polylactic acid, polyglycolic acid, lactic acid glycolic acid copolymer, polymethyl methacrylate, polycaprolactone, and collagen, but only some materials can be integrated with biological components through bioprinting , limiting its application in 3D printed bone tissue scaffolds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for preparing a 3D printing material for a bone repair scaffold, the technical scheme is as follows:

[0019] According to the number of parts by mass, add 10g of nano-calcium hydroxyphosphate and 95g of phosphate buffer solution into the reaction kettle, stir for 60min, and make a uniform suspension; additionally take 4g of sodium alginate, 0.3g of trifluorodimethyl Boron sulfide, 0.6g of diethylaminoethyl cross-linked sephadex, 0.09g of tetraethylammonium tetrachloronickelate, 6.5g of polyethylene glycol (molecular weight 8000) were added to the reaction kettle , control the reaction temperature at 35-40°C, and react for 4 hours to obtain a composite hydrogel material; use the composite hydrogel as a 3D printing ink to print out the required bone repair scaffold, and then soak the scaffold in 3.5% chlorine at a temperature of 36°C The curing reaction is completed in the calcium chloride solution for 12 hours, and the required bone repair scaffold can be obtai...

Embodiment 2

[0024] A method for preparing a 3D printing material for a bone repair scaffold, the technical scheme is as follows:

[0025] According to the number of parts by mass, add 5g of nano-hydroxycalcium phosphate and 90g of phosphate buffer solution into the reaction kettle, stir for 50 min to make a uniform suspension; additionally take 3g of sodium alginate, 0.1g of trifluorodi Add boron methyl sulfide, 0.3 g of diethylaminoethyl cross-linked sephadex, 0.03 g of tetraethylammonium tetrachloronickelate, 5 g of polyethylene glycol (molecular weight: 7000) into the reaction kettle , control the reaction temperature at 35 °C, and react for 3 h to obtain a composite hydrogel material; use the composite hydrogel as a 3D printing ink to print out the required bone repair scaffold, and then soak the scaffold in 2% chloride chloride at a temperature of 35 °C After 10 h in the calcium solution to complete the curing reaction, the desired bone repair scaffold can be obtained.

[0026] Desc...

Embodiment 3

[0030] A method for preparing a 3D printing material for a bone repair scaffold, the technical scheme is as follows:

[0031] According to the number of parts by mass, 15g of nano-calcium hydroxyphosphate and 100g of phosphate buffer solution were added to the reaction kettle, and stirred for 70min to make a uniform suspension; another 5g of sodium alginate, 0.7g of trifluorodimethyl Boron sulfide, 0.8g of diethylaminoethyl cross-linked sephadex, 0.3g of tetraethylammonium tetrachloronickelate, and 8g of polyethylene glycol (molecular weight: 10,000) were added to the reaction kettle , control the reaction temperature at 40°C, and react for 5 hours to obtain a composite hydrogel material; use the composite hydrogel as a 3D printing ink to print out the required bone repair scaffold, and then soak the scaffold in 5% calcium chloride at a temperature of 38°C The curing reaction is completed in the solution for 14 hours, and the required bone repair scaffold can be obtained.

[...

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PUM

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Abstract

The invention relates to the technical field of printing, in particular to a preparation method of a 3D printing material for a bone repairing stent. According to the method, 5-15 parts of nanometer hydroxy calcium phosphate, 90-100 parts of phosphate buffering solution, 3-5 parts of sodium alginate and 5-8 parts of polyethylene glycol are adopted for preparing a composite hydrogel, a demanded bone tissue stent is formed by means of 3D printing and then soaked in a calcium chloride solution to complete a solidification reaction, and then the demanded bone repairing stent is obtained. The prepared 3D printing material for the bone repairing stent not only has great mechanical performance and structural stability but also can further facilitate regeneration of bones by integrating cells andbioactive factors.

Description

technical field [0001] The invention relates to the technical field of material preparation, in particular to a method for preparing a 3D printing material for a bone repair bracket. Background technique [0002] 3D printing is a new method that can overcome the limitations of current tissue engineering technology. The use of 3D printing to construct prostheses similar in composition and structure to natural tissues and organs has become one of the research hotspots in the field of biomedical engineering. [0003] CN106117881A discloses a artificial leather 3D printing material and its preparation method, which consists of the following components in parts by weight: 25-95 parts of polymer material; 0-30 parts of plasticizer; 0-2 parts of compatibilizer; collagen 5-30 parts of fiber; 0-20 parts of microfiber; 0.1-1 part of antioxidant; 0.1-2 parts of lubricant; 0-1 part of stabilizer. No waste water discharge, less pollution; high strength, good elasticity, good mechanical ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50B33Y70/00
CPCA61L27/46A61L27/50A61L2430/02B33Y70/00C08L5/04C08L5/02C08L71/02
Inventor 许宏军孔令飞武春华李洪波贾星恩
Owner 许宏军
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