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Pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate granules and preparation method thereof

A technology for pediatric paracetamol and composition, which is applied to the field of pediatric paracetamol xanthamine composition granules and their preparation fields, can solve the problems of unstable product quality, inconvenience to take, poor stability and the like, and achieves improved granule solubility and improved stability. The effect of stability and good stability

Inactive Publication Date: 2018-06-22
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the traditional preparation method has the problem of uneven mixing of the main drug and auxiliary materials in the granulation process, resulting in unqualified identification items of chlorpheniramine maleate in the finished product, uneven content, large fluctuations in content, unstable product quality, and granules. Not instant, inconvenient to take, and poor stability

Method used

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  • Pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate granules and preparation method thereof
  • Pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate granules and preparation method thereof
  • Pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of Pediatric paracetamol xanthramine composition granule, it is made by following method:

[0043] The raw materials for configuring active ingredients include: 25 parts by weight of acetaminophen, 1 part by weight of artificial bezoar, 0.095 parts by weight of chlorpheniramine maleate, 779 parts by weight of sucrose, and 1.2 parts by weight of essence.

[0044] Add the sucrose into the pulverizer, grind it into fine powder, pass through an 80-mesh sieve, and divide it into the first part of sucrose and the second part of sucrose. Mix acetaminophen, artificial bezoar, chlorpheniramine maleate and the first part of sucrose to obtain a mixture. Add the second part of the sucrose aqueous solution to the mixture at 3000Pa and 35°C to make soft materials. After granulation, first sieve with a 60-mesh stainless steel screen to recover the material on the sieve, and then pass the obtained under-sieve material through a 10-mesh Sieve through a stainless steel screen to ...

Embodiment 2

[0047] A kind of Pediatric paracetamol xanthramine composition granule, it is made by following method:

[0048] The raw materials for configuring active ingredients include: 25 parts by weight of acetaminophen, 1 part by weight of artificial bezoar, 0.095 parts by weight of chlorpheniramine maleate, 779 parts by weight of sucrose, and 1.2 parts by weight of essence.

[0049] Add the sucrose into the pulverizer, grind it into fine powder, pass through an 80-mesh sieve, and divide it into the first part of sucrose and the second part of sucrose. After mixing acetaminophen, artificial bezoar, and chlorpheniramine maleate, the first part of sucrose was added in 5 times under the condition of 45 r / min to obtain a mixture. Add the second part of the sucrose aqueous solution to the mixture at 3000Pa and 35°C to make soft materials. After granulation, first sieve with a 60-mesh stainless steel screen to recover the material on the sieve, and then pass the obtained under-sieve materia...

Embodiment 3

[0052] A kind of Pediatric paracetamol xanthramine composition granule, it is made by following method:

[0053] Raw materials for configuring active ingredients, which include: 25 parts by weight of acetaminophen, 1 part by weight of artificial bezoar, 0.095 parts by weight of chlorpheniramine maleate, 779 parts by weight of sucrose, and 0.03 parts by weight of a water-soluble shell polysaccharide, and the essence of 1.2 parts by weight. Add the sucrose into the pulverizer, grind it into fine powder, pass through an 80-mesh sieve, and divide it into the first part of sucrose and the second part of sucrose. Mix acetaminophen, artificial bezoar, chlorpheniramine maleate and the first part of sucrose to obtain a mixture. Add the second part of the sucrose aqueous solution to the mixture at 3000Pa and 35°C to make soft materials. After granulation, first sieve with a 60-mesh stainless steel screen to recover the material on the sieve, and then pass the obtained under-sieve mater...

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Abstract

The invention relates to pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate granules and a preparation method thereof and relates to the medical field. The granules are prepared with the following method: preparing raw materials including 25-27 parts by weight of paracetamol, 0.85-1 part by weight of artificial cow-bezoar, 0.09-0.18 parts by weight of chlorphenamine maleate, 750-800 parts by weight of sucrose and 1-1.5 parts by weight of essence; dividing the sucrose into a first part of sucrose and a second part of sucrose; mixing paracetamol, artificial cow-bezoar, chlorphenamine maleate and the first part of sucrose, mixing the obtained mixture with an aqueous solution of the second part of sucrose in a boiling state, performing granulation and primary drying, spraying essence on the solution, and performing secondary drying. Through cooperation of reasonable proportioning with the preparation method, the stability of the product is effectively improved, and thetaste during taking is improved.

Description

technical field [0001] The invention relates to the field of medicine, and in particular to a composition granule of infantile paracetamol xanthramine and a preparation method thereof. Background technique [0002] Xiaoer Suxiao Huang Namin Granules is an over-the-counter medicine for colds. It used to be called Xiaoer Suxiao Ganmao Granules, Xiaoer Suxiao Ganmao Ling or Xiaoer Suxiao Ganmao Granules. [0003] Pediatric paracetamol Huang Namin granule is one of the commonly used anti-cold medicines for children. This product is a compound preparation, mainly composed of acetaminophen (paracetamol), chlorpheniramine maleate (chlorpheniramine) and artificial bezoar. Acetaminophen is an antipyretic and analgesic drug, which mainly acts on antipyretic by inhibiting the synthesis of prostaglandins, increasing skin blood flow, sweating and heat loss. Chlorpheniramine maleate is a histamine H1 receptor antagonist, which can resist telangiectasia caused by allergic reactions (hist...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/26A61K35/413A61K31/4402A61K31/167A61P11/00A61P29/00
CPCA61K9/1623A61K9/1682A61K31/167A61K31/4402A61K35/413A61K2300/00
Inventor 唐攀曾博程杨莉罗磊龙涛陈云朱锋袁开超陈波王凤
Owner 重庆希尔安药业有限公司
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