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Terbinafine hydrochloride cream for dogs and preparation method thereof

A technology for terbinafine hydrochloride and nafine cream, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, ointment delivery, etc., and can solve the problems of non-moisturizing paste, water loss, and Rough and other issues

Active Publication Date: 2021-01-26
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the terbinafine hydrochloride cream preparations currently on the market adopt the traditional cream preparation method, that is, the oil phase and the water phase are prepared respectively, and the two phases are mixed and emulsified to make a cream. For drugs with acidic or high ionic strength such as terbinafine hydrochloride, the cream is often unstable or even demulsified, and the cream is also rough
During the placement of the sample, the milk droplets formed by emulsification are unstable and the water is lost, resulting in a non-moisturizing paste, difficult to apply, slow absorption, and demulsification and stratification
Moreover, if the ph of the sample is too low, the acidity is too high and the skin irritation is too large

Method used

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  • Terbinafine hydrochloride cream for dogs and preparation method thereof
  • Terbinafine hydrochloride cream for dogs and preparation method thereof
  • Terbinafine hydrochloride cream for dogs and preparation method thereof

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preparation example Construction

[0061] The present invention also needs to provide a kind of preparation method of terbinafine hydrochloride cream for dogs, which comprises the steps:

[0062] Mix the oil phase and water phase components in a sealed heating and stirring tank, heat to 75°C-85°C and stir to melt until clarification, prepare a mixed solution and keep it warm at 75°C-85°C; among them, the oil phase and water phase are combined Parts include diluents, thickeners, antioxidants, humectants and water, and may also include preservatives.

[0063] Heat the emulsifier to 20°C-40°C until the emulsifier melts, then add it to the mixed solution, heat to 75°C-85°C and stir to emulsify, then stir while slowly cooling down, and form a cream base after emulsification is complete, and Keep warm to 55°C-65°C; during the emulsification process, the stirring speed is controlled at 180-220r / min, the stirring time is about 15min-30min, and the cooling process is stirred at the same speed. Keep stirring at the same...

Embodiment 1

[0069] The terbinafine hydrochloride cream for dogs described in the embodiment of the present invention consists of the following components by weight: 1.0 parts of terbinafine hydrochloride, 8 parts of propylene glycol, 1.0 parts of menthol, polyethylene glycol-7 hard 12 parts of fatty acid esters, 6 parts of liquid paraffin, 5 parts of stearyl alcohol, 2 parts of glyceryl monostearate, 0.06 parts of dibutyl hydroxytoluene, 2 parts of isopropyl myristate, 0.15 parts of potassium sorbate, water 65 parts, 6 parts of triethanolamine.

[0070] Above-mentioned terbinafine hydrochloride cream for dogs, its preparation method is: liquid paraffin, stearyl alcohol, glyceryl monostearate, dibutyl hydroxytoluene, isopropyl myristate and potassium sorbate and water Mix in a sealed heating and stirring tank, heat the sealing and heating stirring tank to 80°C, and stir at 180r / min while heating, so that the above components are melted to become a clear liquid, and the mixed solution is pr...

Embodiment 2

[0072] Terbinafine hydrochloride emulsifiable cream for dogs described in the embodiments of the present invention is composed of the following components by weight: 0.5 part of terbinafine hydrochloride, 3 parts of ethanol, 2 parts of lauroazepine, 0.5 part of menthol, 8 parts of sodium lauryl sulfate, 4 parts of propylene glycol, 4 parts of cetyl alcohol, 0.03 parts of butylated hydroxyanisole, 11 parts of LIPONIC EG-11 parts, 0.08 parts of sorbic acid, 49.7 parts of water, and 3 parts of 10% NaOH solution.

[0073] The above-mentioned terbinafine hydrochloride cream for dogs is prepared by mixing propylene glycol, cetyl alcohol, butylated hydroxyanisole, LIPONIC EG-1, sorbic acid and water in a sealed heating and stirring tank, sealing and heating and stirring Heat the tank to 75°C, stir at 200r / min while heating, so that the above components melt to become a clear liquid, prepare a mixed solution and keep it at 75°C; add sodium lauryl sulfate to the mixed solution, and heat...

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Abstract

The invention discloses terbinafine hydrochloride cream for dogs and a preparation method thereof. The terbinafine hydrochloride cream for dogs comprises the following components: terbinafine hydrochloride, drug dissolving agent and transdermal penetration agent, cooling agent, emulsifier, diluent, thickener, antioxidant, moisturizing agent and water . The preparation method of the terbinafine hydrochloride cream for dogs of the present invention is as follows: the oil phase and the water phase components are mixed, then an emulsifier is added for emulsification, and finally a medicinal solution at the same temperature is added to obtain the product. The terbinafine hydrochloride emulsifiable paste for dogs of the invention can keep moist and delicate for a long time, has good spreadability, transdermal absorbability and high stability.

Description

technical field [0001] The invention relates to the technical field of pet medicines, in particular to terbinafine hydrochloride cream for dogs and a preparation method thereof. Background technique [0002] Canine fungal dermatosis is one of the common clinical canine contagious skin diseases, which refers to the massive reproduction of various pathogenic skin fungi in the coat, epidermis, toe claws, and keratin tissues of various animals, adhering to and invading superficial skin Skin tissue, thus triggering a series of superficial organic lesions, causing various skin diseases, or superficial mycoses. The clinical symptoms are manifested as depilatory round spots, scales, scabs or itching with obvious boundaries on the skin. If secondary bacterial infection occurs, impetigo may form. Canine dermatophytosis is mainly transmitted through direct contact, and can be transmitted between dogs and between humans and dogs through contact, and can also be transmitted through cont...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/137A61K47/10A61K47/06A61K47/14A61K47/12A61P31/10A61P17/00
CPCA61K9/0017A61K9/06A61K31/137A61K47/06A61K47/10A61K47/12A61K47/14
Inventor 陶映娴马静蓉赵奉君
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD