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Preparation method of hydroxyapatite/bioglass material for bone repair

A hydroxyapatite and bioglass technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problem of difficult to meet the performance requirements of biomedical materials, and achieve the effect of easy degradation

Inactive Publication Date: 2018-07-06
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, it is difficult to meet the performance requirements of biomedical materials only by a single material

Method used

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  • Preparation method of hydroxyapatite/bioglass material for bone repair
  • Preparation method of hydroxyapatite/bioglass material for bone repair
  • Preparation method of hydroxyapatite/bioglass material for bone repair

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preparation example Construction

[0026] A method for preparing a hydroxyapatite / bioglass material for bone repair, comprising the following steps:

[0027] (1) Weigh calcium nitrate tetrahydrate and diammonium hydrogen phosphate in the laboratory with a molar ratio of Ca / P=1.67, first dissolve calcium nitrate tetrahydrate in water, then adjust the pH to 14 with concentrated sodium hydroxide, and then add The good diammonium hydrogen phosphate is mixed and stirred on a magnetic stirrer at 80°C for 2 hours; then aged at 100°C for 12 hours, then suction-filtered and dried to obtain hydroxyapatite;

[0028] (2) Melting molten glass with a lifting furnace according to the formula of biological glass, then quenching the molten glass with water, drying the obtained glass, grinding it into powder, and obtaining biological glass powder for subsequent use; the biological glass is 13-93 biological glass ;

[0029] (3) Mix hydroxyapatite and biological glass powder according to the mass ratio of (1-4): (4-1), press and ...

Embodiment 1

[0032] (1) Weigh calcium nitrate tetrahydrate and diammonium hydrogen phosphate in the laboratory with a molar ratio of Ca / P=1.67, first dissolve calcium nitrate tetrahydrate in water, then adjust the pH to 14 with concentrated sodium hydroxide, and then add The good diammonium hydrogen phosphate is stirred after mixing, and stirred on a magnetic stirrer at 80°C for 2 hours, then aged at 100°C for 12 hours, and then dried by suction to obtain hydroxyapatite;

[0033] (2) According to 13-93 bioglass 36B 2 o 3 -18SiO2 2 -22CaO-6Na 2 O-MgO-8K 2 O-2P 2 o 5 Melt the molten glass with a lifting furnace, then quench the molten glass with water, dry the obtained glass, grind it into powder, and obtain biological glass powder for use;

[0034] (3) Weigh 2g of hydroxyapatite and biological glass powder according to the mass ratio of 1:4 for mixing, press molding under 20MPa pressure, and calcinate the sample at 670°C to obtain hydroxyapatite for bone repair stone / bioglass materia...

Embodiment 2

[0036] (1) Weigh calcium nitrate tetrahydrate and diammonium hydrogen phosphate in the laboratory with a molar ratio of Ca / P=1.67, first dissolve calcium nitrate tetrahydrate in water, then adjust the pH to 14 with concentrated sodium hydroxide, and then add The good diammonium hydrogen phosphate is stirred after mixing, and stirred on a magnetic stirrer at 80°C for 2 hours, then aged at 100°C for 12 hours, and then dried by suction to obtain hydroxyapatite;

[0037] (2) According to 13-93 bioglass 36B 2 o 3 -18SiO2 2 -22CaO-6Na 2 O-MgO-8K 2 O-2P 2 o 5 Melt the molten glass with a lifting furnace, then quench the molten glass with water, dry the obtained glass, grind it into powder, and obtain biological glass powder for use;

[0038] (3) Weigh 2 g of hydroxyapatite and biological glass powder according to the mass ratio of 2:3 for mixing, press molding under a pressure of 20 MPa, and calcinate the sample at 670 ° C to obtain hydroxyapatite for bone repair stone / bioglas...

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Abstract

The invention discloses a preparation method of a hydroxyapatite / bioglass material for bone repair. The preparation method is characterized by comprising steps of firstly weighing calcium nitrate terahydrate and diammonium hydrogen phosphate according to the molar ratio Ca / P being equal to 1.67, dissolving the calcium nitrate terahydrate into water, using aqueous sodium hydroxide for adjusting pHto be alkaline, adding the weighed diammonium hydrogen phosphate, stirring after mixing, and after stirring, ageing, carrying out suction filtration and drying to obtain hydroxyapatite; then melting to obtain molten glass according to a bioglass formula, water-quenching the molten glass, drying obtained glass, grinding into powder, and obtaining bioglass powder; finally mixing the hydroxyapatite and the bioglass powder, pressing for forming, and calcining to obtain the hydroxyapatite / bioglass material for bone repair. The hydroxyapatite / bioglass material for bone repair prepared through the preparation method provided by the invention is higher in strength, easy to degrade and better in biocompatibility at the same time.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a hydroxyapatite / biological glass material used for bone repair. Background technique [0002] Biomedical materials have a very long history. In the 21st century, with the advancement of medicine, the average life span of human beings is also increasing, and organ failure and tissue defects have become one of the important problems that hinder the further extension of human life span. Therefore, most patients can only take other treatment methods, such as surgical reconstruction, drug therapy, synthetic prosthesis and mechanical devices. Although these methods are unrestricted, they cannot replace the full functions of failed organs or tissues for a long time, and fundamentally solve the disease. Therefore, the artificial synthesis of tissue substitutes with long-term biological activity has become a hot research topic. [0003] Hydroxyapatite, which bel...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/58A61L27/56
CPCA61L27/10A61L27/12A61L27/56A61L27/58A61L2430/02
Inventor 乔荫颇李明阳杨晨高杨周沁李新宇
Owner SHAANXI UNIV OF SCI & TECH
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