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Bone fusion body and preparing method thereof

A bone fusion and fusion body technology, applied in the field of medical materials, can solve the problems of not being able to provide osteoblasts and bone fusion bodies cannot be biologically fixed, and achieve the effects of enhancing biological fixation, promoting fixation and growth, and improving resistance

Inactive Publication Date: 2018-07-10
BEIJING AKEC MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a bone fusion body and its preparation method to solve the problem that the ethylene glycol compounds in the prior art cannot provide osteoblasts and cause the bone fusion body to fail to be biologically fixed

Method used

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  • Bone fusion body and preparing method thereof
  • Bone fusion body and preparing method thereof
  • Bone fusion body and preparing method thereof

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preparation example Construction

[0030] In another typical embodiment of the present application, a method for preparing a bone fusion body is provided. The preparation method includes: electrolytically treating the medical metal matrix with an electrolyte, wherein the medical metal is the anode, and the electrolyte contains Ca 2+ and P 5+ , forming a nanotube structure on the surface of a medical metal substrate and depositing HA nanoparticles on the end face of the nanotube structure and the inner wall near the end face to obtain a nanostructure; impregnating the nanostructure in 3-(trifluoromethyl)benzylsulfur In alcohol, after 20-50h, a 3-(trifluoromethyl)benzyl mercaptan attachment layer connected by chemical bonds is formed on the surface of the nanotube structure of the medical metal substrate to obtain the first attachment; prepare polyethylene methacrylate A mixed solution formed by glycol methyl ether ester, polyethylene glycol methacrylate, CuCl, water, ethanol and osteoblasts; under the protectio...

Embodiment 1

[0044] The surface of the 3D printed porous titanium alloy bone fusion body was sandblasted with titanium alloy powder in the order of 600 mesh to 1200 mesh to obtain a sandblasted body, and then the sandblasted body was ultrasonically treated with acetone, ethanol and distilled water for 20 minutes. Vacuum drying at 100°C to obtain the medical metal substrate 10; in the anodizing electrolyte, connect the medical metal substrate 10 to the anode of the power supply, use a platinum sheet electrode as the cathode, and slowly increase the anodizing voltage to the final voltage at a rate of 5V / s 70V, during the oxidation process, the electrolyte has been electromagnetically stirred, and the electrolyte contains 0.29mol of Ca and P ions. After 25 minutes, the anodic oxidation treatment is completed, and immediately rinsed with a large amount of distilled water and dried to obtain a nanostructure; then the nanostructure body soaked in 10mmol3-(trifluoromethyl) benzyl mercaptan, soaked...

Embodiment 2

[0046] The surface of the 3D printed porous titanium alloy bone fusion body was sandblasted with titanium alloy powder in the order of 600 mesh to 1200 mesh to obtain a sandblasted body, and then the sandblasted body was ultrasonically treated with acetone, ethanol and distilled water for 20 minutes. Vacuum drying at 100°C to obtain the medical metal substrate 10; in the anodic oxidation electrolyte, the medical metal substrate 10 is connected to the anode of the power supply, the cathode uses a platinum sheet electrode, and the anodic oxidation voltage is slowly increased to the final voltage at a rate of 2V / s 70V, during the oxidation process, the electrolyte has been electromagnetically stirred, and the electrolyte contains 0.25mol of Ca and P ions. After 25 minutes, the anodic oxidation treatment is completed, and immediately rinsed with a large amount of distilled water and dried to obtain a nanostructure; then the nanostructure The body was soaked in 10mmol 3-(trifluorome...

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Abstract

The invention provides a bone fusion body and a preparing method thereof. The bone fusion body comprises a medical metal matrix of which the surface is of a nanotube structure, HA nanometer particles,a 3-(trifluoromethyl)benzyl mercaptan adhering layer and an ethylene glycol compound adhering layer, wherein the HA nanometer particles adhere to the end face of the nanotube structure and the innerwall close to the end face, the 3-(trifluoromethyl)benzyl mercaptan adhering layer is connected with the metal matrix through chemical bonds and adheres to the surface of the nanotube structure, the ethylene glycol compound adhering layer adheres to the 3-(trifluoromethyl)benzyl mercaptan adhering layer, is connected with the 3-(trifluoromethyl)benzyl mercaptan adhering layer through chemical bonds and is provided with a cavity which is matched with a spatial structure of the osteoblast, and at least part of the HA nanometer particles is exposed into the cavity. The nanotube structure makes adhering of the adhering layer firmer, and the resistance capability of bacterial adhesion is improved; the exposed HA nanometer particles can play the effect of promoting the fixation and growth of theosteoblast, and then the biological fixation effect of the bone fusion body is improved.

Description

technical field [0001] The invention relates to medical materials, in particular to a bone fusion body and a preparation method thereof. Background technique [0002] Intervertebral disc degenerative disease is a common orthopedic disease. Modern medicine has implemented intervertebral fusion surgery to treat intervertebral disc degenerative disease. Implants need to cooperate with bone grafts to achieve intervertebral fusion, while the current conventional method in the medical field is intervertebral implantation of autologous bone or allogeneic bone, built-in metal supporter or intervertebral fusion device, etc. However, due to the limited sources of autologous bone and the high price and biological risks of allograft bone, not every patient who needs bone defect filling can receive satisfactory treatment. At the same time, infection is prone to occur during such operations, which may lead to serious consequences such as massive antibiotic treatment, removal of intervert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/06A61L27/04A61L27/12A61L27/50A61L27/54A61L27/56
CPCA61L27/045A61L27/047A61L27/06A61L27/12A61L27/50A61L27/54A61L27/56A61L2400/12A61L2300/412A61L2300/404
Inventor 李健
Owner BEIJING AKEC MEDICAL
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