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Pharmaceutical composition for treating colon cancer and application thereof

A composition and colon cancer technology, applied in the field of medicine, can solve problems such as unsatisfactory therapeutic effects, side effects, and hidden dangers of drug safety of Chinese patent medicines, and achieve the goals of improving drug safety, inhibiting proliferation, and reducing the risk of bleeding Effect

Inactive Publication Date: 2018-07-13
张守芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Barasertib is a selective inhibitor of Aurora kinase (Aurora B), which can inhibit the proliferation of hematopoietic malignant cells. It can significantly inhibit the growth of a variety of human solid xenografts, including colon cancer and breast cancer. However, the drug There are certain side effects after use, and there are hidden dangers in the safety of medication
The existing technology shows that Chinese patent medicine or Chinese medicine components have fewer side effects when used to treat colon cancer, but the drug treatment effect of Chinese patent medicine is not satisfactory

Method used

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  • Pharmaceutical composition for treating colon cancer and application thereof
  • Pharmaceutical composition for treating colon cancer and application thereof
  • Pharmaceutical composition for treating colon cancer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of Compound Tablets

[0025]

[0026] Wherein, the dosage of 15% starch slurry in the tablet is not strictly limited, and those skilled in the art can make a suitable selection and determination according to the actual situation. Give a detailed description.

[0027] Preparation process: 2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazole-5- Base}-N-(3-fluorophenyl)acetamide, 1,8-dihydroxy-3-carboxyanthraquinone, microcrystalline cellulose and starch are mixed evenly, and an appropriate amount of 15% starch slurry is added to make soft material, and then Granulate through a 16-mesh sieve, dry the wet granules at 60°C, granulate the dry granules through a 16-mesh sieve, sift out the fine powder in the dry granules, mix with magnesium stearate, then mix with the dry granules, and press into tablets , can obtain compound tablet of the present invention.

Embodiment 2

[0029] Preparation of Compound Dispersible Tablets

[0030]

[0031] Wherein, the dosage of 5%PVP60% ethanol in the tablet is not strictly limited, and those skilled in the art can make a suitable selection and determination according to the actual situation, as long as the dosage is convenient for the preparation of dispersible tablets. Give a detailed description.

[0032] Preparation process: Weigh 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazole -5-yl}-N-(3-fluorophenyl)acetamide and 1,8-dihydroxy-3-carboxyanthraquinone, with microcrystalline fiber, croscarmellose sodium and polyvinylpyrrolidone as disintegration Debonding agent, 5%PVP60% ethanol is binding agent, micropowder silica gel is glidant, with fluidized bed one-step granulation, finally tabletting, can obtain compound dispersible tablet of the present invention.

Embodiment 3

[0034] Preparation of Compound Granules

[0035]

[0036] Wherein, the dosage of 80% ethanol in the tablet is not strictly limited, and those skilled in the art can make a suitable selection and determination according to the actual situation, as long as the dosage is convenient for the preparation of granules, and will not be detailed here. describe.

[0037] Preparation process: Weigh 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazole -5-yl}-N-(3-fluorophenyl)acetamide, 1,8-dihydroxy-3-carboxyanthraquinone, starch, dextrin and sucrose powder were mixed evenly, and an appropriate amount of 80% ethanol was added to In the mixed powder, mix evenly, make a soft material, pass through a 18-mesh nylon sieve to make wet granules, dry at about 60°C, granulate with a 20-mesh sieve, and pack separately to obtain the compound granules of the present invention.

[0038] Inhibitory effect of the pharmaceutical composition of the present invention on c...

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Abstract

The invention provides a pharmaceutical composition for treating colon cancer and application thereof. The pharmaceutical composition for treating colon cancer consists of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide and 1,8-dihydroxy-3-carboxyanthraquinone. A compound group and a single drug group provided by the inventionboth have inhibitory effects on a colon cancer cell strain SW1116 in vivo, wherein the tumor inhibitory rate of the compound group is significantly different from that of the single drug group of 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazoline-4-yl)amino]-1H-pyrazole-5-yl}-N-(3-fluorophenyl) acetamide or the single drug group of 1,8-dihydroxy-3-carboxyanthraquinone; and both groups play a significant synergistic role in inhibiting the proliferation of the colon cancer cell strain SW1116, in which the compound group can inhibit the growth of colon tumor, and the tumor inhibitory rate can reach up to 90.3%.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating colon cancer and its application, belonging to the technical field of medicine. Background technique [0002] At present, cancer is one of the major diseases that seriously affect human health and threaten human life. Cancer, cardiovascular and cerebrovascular diseases and accidents together constitute the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world. One is to use surgical resection to remove the diseased tissue to prevent the spread of cancer cells; the other is to use chemotherapy or radiotherapy to kill cancer cells; the third is to use drugs to treat it. [0003] Colon cancer is a common malignant tumor of the digestive tract that occurs in the colon, and it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61K31/192A61P35/00
CPCA61K31/192A61K31/517A61K2300/00
Inventor 张守芬
Owner 张守芬
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