Preparation method of gold-copper sulfide nano material with hollow core-shell structure and application thereof

A technology of nanomaterials and core-shell structure, applied in the field of nanomaterials, can solve the problems of low photothermal efficiency of copper sulfide

Inactive Publication Date: 2018-07-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the relatively low photothermal efficiency of copper sulfide, the photothermal eff...

Method used

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  • Preparation method of gold-copper sulfide nano material with hollow core-shell structure and application thereof
  • Preparation method of gold-copper sulfide nano material with hollow core-shell structure and application thereof
  • Preparation method of gold-copper sulfide nano material with hollow core-shell structure and application thereof

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preparation example Construction

[0041] The invention provides a method for preparing a gold-copper sulfide nanomaterial with a hollow core-shell structure, comprising the following steps:

[0042] a) cetyltrimethylammonium bromide, chloroauric acid and sodium borohydride are mixed and reacted to obtain a gold seed solution;

[0043] b) mixing cetyltrimethylammonium bromide, silver nitrate, chloroauric acid, ascorbic acid and gold seed solution, and standing to grow to obtain gold core nanomaterials;

[0044] c) mixing and reacting polyvinylpyrrolidone, water, copper chloride and gold core nanomaterials to obtain a first reaction product;

[0045] d) reacting the first reaction product with sodium hydroxide to obtain a second reaction product;

[0046] e) reacting the second reaction product with hydroxylamine hydrochloride to obtain a third reaction product;

[0047] f) reacting the third reaction product with sodium sulfide, centrifuging, washing and drying the obtained precipitate to obtain a gold-copper...

Embodiment 1

[0085] (1) Gold seed solution synthesis, 5mL 0.2mol / L cetyltrimethylammonium bromide and 5mL 0.5mmol / L chloroauric acid solution were mixed and stirred for 2 minutes, and 0.6mL 0..01mol / L sodium borohydride was added The solution was vigorously stirred for 2 minutes, then stood at 30°C for 30 minutes;

[0086] (2) Gold nanomaterial growth solution, add 0.3mL4mmol / L silver nitrate solution in 5mL 0.2mol / L cetyltrimethylammonium bromide solution, then add 5mL 1mmol / L chloroauric acid solution and stir slowly for 5 Minutes, add 70 μL 78.8mmol / L ascorbic acid solution, and finally add 70 μL seed solution, let it stand at 30°C for 12 hours to obtain a gold core nano solution;

[0087] (3) After adding 0.2g polyvinylpyrrolidone (K-30) into 20mL water and stirring to dissolve, add 1mL0.2mol / L copper chloride solution and stir for 2 minutes, then add 0.5mL 5μg / mL gold core nanomaterial solution and stir for 5 minute;

[0088] (4) Add 0.3mL 2mol / L sodium hydroxide solution to the abo...

Embodiment 2

[0100] The difference from Example 1 is that 3 mL of 5 μg / mL gold core nanomaterial solution is added in step (3). The resulting product is referred to as gold-copper sulfide (2).

[0101] from image 3 It can be seen that the gold-copper sulfide nanoparticles with a hollow core-shell structure prepared in Example 2 have a hollow distance of 17.5 nm, and the hollow structure is very obvious, and the particle size is uniform.

[0102] The ultraviolet-visible-near-infrared absorption spectrum test result of the gold-copper sulfide nanomaterial prepared in embodiment 2 is shown in Figure 4 .

[0103] The photothermal heating curve of the gold-copper sulfide nanomaterial prepared in embodiment 2 is shown in Figure 5 .

[0104] The free radical generation curve figure of the gold-copper sulfide nanomaterial prepared in embodiment 2 is shown in Image 6 .

[0105] The biosafety evaluation figure of the gold-copper sulfide nanomaterial prepared in embodiment 2 is shown in F...

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Abstract

The invention provides a preparation method of a gold-copper sulfide nano material with a hollow core-shell structure and application thereof. The preparation method comprises the following steps of:mixing hexadecyl trimethyl ammonium bromide, chloroauric acid and sodium borohydride, and reacting to obtain gold seed solution; mixing the hexadecyl trimethyl ammonium bromide, silver nitrate, the chloroauric acid, ascorbic acid and the gold seed solution, and standing for growth to obtain a gold-core nano material; mixing polyvinylpyrrolidone, water, copper chloride and the gold-core nano material, and reacting to obtain a first reaction product; reacting the first reaction product with sodium hydroxide, reacting the obtained second reaction product with hydroxylamine hydrochloride, then reacting with sodium sulfide, centrifuging, cleaning obtained precipitates and then drying to obtain the gold-copper sulfide nano material with the hollow core-shell structure. The gold-copper sulfide nano material prepared by the preparation method has the advantages that under the irradiation of near-infrared light, the photothermal property of the copper sulfide is obviously improved by the plasmaresonance energy transfer mechanism of gold nano particles; the photodynamic property is higher; chemotherapeutic drugs also can be carried, and the tumor-cell killing efficiency is higher.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a preparation method and application of a gold-copper sulfide nanomaterial with a hollow core-shell structure. Background technique [0002] Tumor treatment techniques can eradicate tumors, so multimodal combined tumor treatment modalities have attracted widespread attention, especially the combination of three treatment modalities including chemotherapeutic drug therapy, photothermal therapy, and photodynamic therapy. Because combined treatment in the tumor area can improve the efficiency of treatment and reduce the corresponding side effects, photothermal therapy is a low-invasive treatment method. The heat generated by the photothermal agent at the local location can kill tumor cells while Enhance the metabolism of surrounding cells and the permeability of cell membranes to improve the therapeutic efficiency of chemotherapy drugs, and photodynamic therapy can generate re...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K31/704A61P35/00
CPCA61K9/5115A61K31/704A61K41/0052A61K41/0057A61K2300/00
Inventor 张海元常赟程岩冯艳林孙秀娟
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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