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Graphdiyne nanosheet based multifunctional medicine carrying system as well as preparation method and application thereof

A nanosheet and graphdiyne technology is applied in the field of graphdiyne nanosheet-based multifunctional drug-carrying system and its preparation to achieve the effects of tumor targeting, good photothermal effect, and significant tumor growth inhibition ability.

Active Publication Date: 2018-07-20
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies using graphyne as a drug delivery system have not been reported

Method used

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  • Graphdiyne nanosheet based multifunctional medicine carrying system as well as preparation method and application thereof
  • Graphdiyne nanosheet based multifunctional medicine carrying system as well as preparation method and application thereof
  • Graphdiyne nanosheet based multifunctional medicine carrying system as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] In this example, GDY / DOX was prepared by the following method, specifically including the following steps:

[0060] 1) Use an ultrasonic cell disruptor with an ultrasonic power of 200W to sonicate 1 mg / mL GDY for 1 hour to obtain GDY dispersion A.

[0061] 2) Add the dispersion A obtained in step 1) into a polyethylene glycol diamine solution with a weight average molecular weight of 2000 and a concentration of 2 mg / mL, and the mass ratio of polyethylene glycol diamine to the GDY is 2:1, Magnetic stirring was carried out at 20° C. at a rotation speed of 100 rpm for 4 h to obtain dispersion B.

[0062] 3) Add the dispersion B obtained in step 2) into DOX with a concentration of 1mg / mL, the mass ratio of DOX to GDY is 1:1, and magnetically stir at 500rpm at 20°C for 12h to obtain GDY / DOX .

[0063] The GDY provided by the present embodiment is observed by a transmission electron microscope, and the results are as follows: figure 1 shown, from figure 1 It can be seen f...

Embodiment 2

[0065] 1) Sonicate 2 mg / mL GDY for 4 hours with an ultrasonic cell disruptor with an ultrasonic power of 300W to obtain GDY dispersion A.

[0066] 2) Add the dispersion A obtained in step 1) into a polyethylene glycol diamine solution with a weight average molecular weight of 3000 and a concentration of 4 mg / mL, the mass ratio of polyethylene glycol diamine to the GDY is 2:1, Magnetic stirring was performed at 30° C. at a rotation speed of 500 rpm for 4 h to obtain dispersion B.

[0067] 3) Add the dispersion B obtained in step 2) into DOX with a concentration of 1mg / mL, the mass ratio of DOX to the GDY is 1:2, and magnetically stir at 1000rpm at 20°C for 12h to obtain GDY / DOX .

[0068] Synthetic GDY / DOX was detected by fluorescence absorption spectroscopy, as figure 2 As shown, the weakening of DOX fluorescence indicates that DOX and GDY stacked through π-π, forming a nanocomposite that leads to the quenching of DOX fluorescence.

Embodiment 3

[0070] 1) Sonicate 2 mg / mL GDY for 6 h with an ultrasonic cell disruptor with an ultrasonic power of 400 W to obtain GDY dispersion A.

[0071] 2) Add the dispersion A obtained in step 1) into a polyethylene glycol diamine solution with a weight average molecular weight of 5000 and a concentration of 1 mg / mL, and the mass ratio of polyethylene glycol diamine to the GDY is 1:2, Magnetic stirring was performed at 30° C. at a rotation speed of 1000 rpm for 6 h to obtain dispersion B.

[0072] 3) Add the dispersion B obtained in step 2) into DOX with a concentration of 2 mg / mL, the mass ratio of DOX to GDY is 1:1, and magnetically stir at 1500 rpm for 18 hours at 30°C to obtain GDY / DOX .

[0073] The graphyne nanosheet-based multifunctional drug-carrying system provided in this example was tested for stability, and the hydrated particle size and zeta potential of GDY / DOX provided in this example were tested during placement. The results were as follows image 3 and Figure 4 As...

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Abstract

The invention provides a graphdiyne nanosheet based multifunctional medicine carrying system as well as a preparation method and application thereof. For the graphdiyne nanosheet based multifunctionalmedicine carrying system, the graphdiyne nanosheet based multifunctional medicine carrying system is a medicine carrying system formed by loading medicine molecules on a graphdiyne nanosheet throughthe Pi-Pi conjugation and electrostatic mutual effect. The graphdiyne nanosheet based multifunctional medicine carrying system can be well dispersed in a water solution, and has good solid tumor high-permeability and retention (EPR) effect; the targeting goal is realized; the characteristics of laser and pH dual response release are realized. The preparation method of the graphdiyne nanosheet based multifunctional medicine carrying system is simple and is easy to implement; the reaction conditions are mild; the medicine carrying rate is high; the introduction of hazardous reagents is avoided;good biocompatibility and safety are realized; wide application prospects are realized in the field of biological medicine.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a graphyne nanosheet-based multifunctional drug-carrying system and a preparation method and application thereof. Background technique [0002] Cancer is one of the most important diseases affecting human beings, which poses a serious threat to the health of the whole human being. Current tumor treatment methods mainly include surgical resection, radiotherapy and chemotherapy. Among them, chemotherapy is the abbreviation of chemical drug therapy. It is one of the most effective means to treat cancer by using chemotherapy drugs to kill cancer cells to achieve the purpose of treatment. However, chemotherapy is a systemic treatment method. Regardless of the route of administration (oral, intravenous and body cavity administration, etc.), the drugs used in chemotherapy (such as adriamycin, cisplatin, ancitabine, etc.) will spread throughout the body with blood circulation. Most of ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K31/4745A61K31/337A61K31/351A61K47/52A61K47/04A61K47/69A61K47/60A61K47/18A61P35/00
CPCA61K31/337A61K31/351A61K31/4745A61K31/704A61K41/0042A61K41/0052A61K47/02A61K47/18A61K2300/00
Inventor 陈春英靳钧
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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