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Water-soluble inlaid thorium fullerene and preparation method and application thereof

A fullerene and water-soluble technology, applied in the field of material chemistry, can solve the problems of difficult scale-up of preparation and low yield of embedded fullerene, and achieve high yield, simple production process and strong operability

Active Publication Date: 2018-07-20
ZHANGJIAGANG INST OF IND TECH SOOCHOW UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the production of embedded fullerenes by ion implantation is very low, and it is difficult to scale up the preparation

Method used

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  • Water-soluble inlaid thorium fullerene and preparation method and application thereof
  • Water-soluble inlaid thorium fullerene and preparation method and application thereof
  • Water-soluble inlaid thorium fullerene and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047](1) Preparation of fullerene: Drill a solid spectrally pure graphite rod with a diameter of 8 mm and a length of 100 mm into a hollow graphite rod with an inner diameter of 6 mm and a depth of about 80 mm. ThO 2 The mixture of graphite and graphite powder (molar ratio 1:24) was filled into the above-mentioned hollow graphite rod and compacted. The filled graphite rods were placed in a high-temperature tube furnace and heated to 1000 °C under a high-purity Ar atmosphere, and kept for 10 hours to serve as anodes. A solid spectrally pure graphite rod serves as the cathode.

[0048] Install the pretreated graphite rod on the anode of the vacuum electric arc furnace and fix it, seal the furnace cavity, turn on the vacuum pump, pump the furnace cavity to a pressure lower than 10 Pa, turn off the vacuum pump, and fill the furnace cavity with high-purity He gas , the air pressure in the furnace chamber is about 2.95×10 4 Pa. Turn on the circulating cooling water, turn on th...

Embodiment 2

[0056] Filter the solution obtained in step (4) of Example 1 with a 0.45um filter membrane, distill it under reduced pressure to 1mL, add water-soluble ethanol, a poor solvent embedded with thorium fullerene, and precipitate a yellow precipitate, collect it by centrifugation and wash it three times with ethanol , and then the solid was dissolved in deionized water and dialyzed with a dialysis bag with a molecular weight cut off of 3500 to obtain a contrast agent based on water-soluble thorium fullerene embedded. Finally, the obtained water-soluble contrast agent embedded with thorium fullerene is used for CT imaging, and its performance is better than that of iodofluhydrin, see Figure 8 , the first row is the CT imaging image of iodofluhydrin, and the second row is the CT imaging image of the contrast agent based on water-soluble embedded thorium fullerene.

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Abstract

The invention discloses water-soluble inlaid thorium fullerene and a preparation method and application thereof. Specifically, the method includes first vacuating a reaction chamber provided with an electrode, filling the reaction chamber with a He atmosphere having a pressure of (2.5-3.5) *10<4> Pa, using a spectral pure graphite rod as a cathode, taking a hollow graphite rod filled with a ThO2 / graphite powder mixture as an anode, and causing the cathode and the anode to undergo arc discharge at a current intensity of 90 to 100 A in the above mixed atmosphere to prepare inlaid fullerene Th@C82; after chromatographic purification, adding a mixed solvent of hydrogen peroxide and ammonia water (at a ratio of 7:3), and heating the mixture at 50 DEG C to perform stirring for 3 h, to prepare the water-soluble inlaid thorium fullerene. The surface of Th@C82 can be modified with hydrophilic groups, at the same time the surface amino groups also facilitate the further coupling with other bioactive molecules to enhance the targeting, the effect of target diagnosis and treatment is achieved, and a broad selection space is provided for subsequent development.

Description

technical field [0001] The invention belongs to the field of material chemistry, in particular to water-soluble embedded thorium fullerene (Th@C 82 ) and its preparation method and application. Background technique [0002] Water-soluble embedded fullerene is a molecule made by first embedding metal atoms into the interior of the fullerene carbon cage, and then modifying the surface of the fullerene. Due to the embedding of metal atoms in the carbon cage, the structure and various physical and chemical properties of hollow fullerene and other embedded fullerenes are obviously different, and the embedded fullerene is modified by the surface to make it more unique. excellent properties. According to the current relevant experimental results, it can be expected that such compounds have broad application prospects in the fields of biology, medicine, and materials. [0003] The main methods for preparing embedded fullerenes are ion implantation and arc discharge. Among them, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/154A61K49/04
CPCA61K49/04
Inventor 谌宁阳威王姚峰
Owner ZHANGJIAGANG INST OF IND TECH SOOCHOW UNIV
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