Ofloxacin liquid crystal gel nano-particle eye drop and preparation method thereof

Abstract

The invention relates to an ofloxacin liquid crystal nano-particle eye drop and a preparation method thereof. The ofloxacin liquid crystal nano-particle eye drop is prepared from 0.12-0.2% of ofloxacin, 20-50% of at least one neutral lipid and/or tocopherol, 20-50% of at least one phosphatidylcholine, 0.2-20% of a nonionic surfactant, 0.1-10% of at least one solvent, 0.28-0.35% of at least one thickener, and the balance of injection water. The liquid crystal gel nano-particle has a small and uniform particle size, so the endocytosis and the transport of cells are benefited; and the unique adhesion and the liquid crystal phase structure of the liquid crystal gel are used to prolong the retention time of drug active ingredients in eyes and effectively control the release of an entrapped substance, so the bioavailability is improved. Additionally, the preparation method of the ofloxacin liquid crystal gel nano-particle eye drop has the advantages of simple process steps, easiness in industrial large-scale production, and low production cost.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an ofloxacin liquid crystal gel nano particle eye drop and a preparation method thereof. Background technique [0002] With the development of science and technology, more and more electronic products appear in people's lives, and prolonged exposure to electronic products can easily cause dry eye syndrome, keratitis, etc. Big data shows that corneal disease blindness has become one of the main causes of blindness in my country, among which infectious keratitis ranks first. [0003] Today, many eye conditions are still treated with traditional pharmaceutical preparations such as eye drops or ointments. However, due to the particularity of the physiological structure of the eye (such as tear film renewal, corneal permeability and other factors), it is difficult to achieve effective concentrations of eye drugs, and the bioavailability of drugs is too low, resulting in uns...

AI Technical Summary

Problems solved by technology

The problem of common ofloxacin eye drops is obvious. Because its main active ingredient (ie levofloxacin) is very water-soluble, after being dropped into the eye, the first contact is the corneal epithelium with high hydrophobicity. According to similar According to the principle of compatibility, the active ingredients of the drug will be prevented from moving into the eye and entering the eye, so as to flow out quickly; for this reason, some patients have to repeatedly use eye drops in large quantities in order to achieve better therapeutic effects, resulting in The consequences of adverse reactions are also serious, and the effect is not ideal; those skilled in the art try to increase the viscosity of the solution by adding an appropriate amount of thickening substances in the eye drops, thereby indirectly increasing the residence time of the drug in the eye, but the effect bad

However, the eye drops disclosed by the present invention have high viscosity and poor biological sense, so continuous improvement is still needed.

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