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Preparation method of PVP modified prussian blue nanometer material

A nanomaterial, Prussian blue technology, applied in the field of preparation of Prussian blue nanomaterials, can solve problems such as harsh conditions, difficult industrial mass production, and limited application, and achieve high quality and uniform particle size distribution.

Active Publication Date: 2018-07-27
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these two methods also have some inherent defects, such as poor dispersion uniformity and weak magnetic properties of the prepared Prussian blue nanoparticles, which limit their further applications in biomedicine.
The preparation process of the reverse microemulsion method and the template method is relatively complicated, the conditions are also very harsh, and the post-treatment is cumbersome. It is only suitable for laboratory preparation and is difficult for industrial mass production.

Method used

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  • Preparation method of PVP modified prussian blue nanometer material
  • Preparation method of PVP modified prussian blue nanometer material
  • Preparation method of PVP modified prussian blue nanometer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add polyvinylpyrrolidone K30 (1.5g) and potassium ferricyanide (65mg) into the reaction flask, add 20ml of distilled water, stir to fully dissolve, and the solution becomes clear. Then the pH value was adjusted to 2 with hydrochloric acid to obtain a reaction solution. The reaction solution is placed in the center of the coil of the electromagnetic induction heating device, the frequency of the device is 1355KHz, the maximum power is 6KW, and the diameter of the coil is 3.5cm. Turn on the electromagnetic induction heating equipment to generate an alternating magnetic field, adjust the output current to 11 amperes, and maintain it for 10 hours. Turn off the electromagnetic induction heating equipment, wait for the reaction system to cool down to room temperature, and wash with ethanol:water (2:1) solution system for 3 times, the centrifugal force is 10000G, and the temperature is 4°C. Then transfer to a dialysis bag (100KDa dialysis bag), and dialyze with ultrapure wate...

Embodiment 2

[0044] Add polyvinylpyrrolidone K30 (3g) and potassium ferricyanide (65mg) into the reaction flask, add 20ml of distilled water, stir to fully dissolve, and the solution becomes clear. Then the pH was adjusted to 2 with hydrochloric acid to obtain a reaction solution. The reaction solution is placed in the center of the coil of the electromagnetic induction heating device, the frequency of the device is 1355KHz, the maximum power is 6KW, and the diameter of the coil is 3.5cm. Turn on the electromagnetic induction heating equipment to generate an alternating magnetic field, adjust the output current to 11 amperes, and maintain it for 10 hours. Turn off the electromagnetic induction heating equipment, wait for the reaction system to cool down to room temperature, and wash with ethanol:water (2:1) solution system for 3 times, the centrifugal force is 10000G, and the temperature is 4°C. Then transfer to a dialysis bag (100KDa dialysis bag), and dialyze with ultrapure water at roo...

Embodiment 3

[0046] Add polyvinylpyrrolidone K30 (1.5g) and potassium ferricyanide (195mg) into the reaction flask, add 20ml of distilled water, stir to fully dissolve, and the solution becomes clear. Then the pH was adjusted to 1 with hydrochloric acid to obtain a reaction solution. The reaction solution is placed in the center of the coil of the electromagnetic induction heating device, the frequency of the device is 380KHz, the maximum power is 10KW, and the diameter of the coil is 3.5cm. Turn on the electromagnetic induction heating equipment to generate an alternating magnetic field, and adjust the output current to 30 amperes for 10 hours. Turn off the electromagnetic induction heating equipment, wait for the reaction system to cool down to room temperature, and wash with ethanol:water (2:1) solution system for 3 times, the centrifugal force is 10000G, and the temperature is 4°C. Then transfer to a dialysis bag (100KDa dialysis bag), and dialyze with ultrapure water at room temperat...

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Abstract

The invention provides a preparation method of a PVP modified prussian blue nanometer material. The method concretely comprises the following steps of (1) dissolving PVP and precursors into water formixing; (2) adding hydrochloric acid for regulating the pH to an acid state; (3) performing reaction under the electromagnetic induction heating; (4) performing ethanol water centrifugal washing, dialysis and freeze drying to obtain a finished product. According to the method, magnetic inner heat is used for replacing an ordinary external heating mode; in a shorter reaction time, the high-qualityprussian blue nanometer material can be obtained. The PVP modified prussian blue nanometer material prepared by the method has the advantages of small polydispersity coefficient, uniform particle dimension distribution, higher magnetism and higher nanometer enzymatic activity.

Description

technical field [0001] The invention relates to a preparation method of a polyvinylpyrrolidone (PVP) modified Prussian blue nano material, specifically, comprising a method for preparing a PVP modified Prussian blue nano material by using an alternating magnetic field-induced magneto-induced internal heat method. Background technique [0002] Due to its good photoelectric properties, unique porous structure and biocompatibility, Prussian blue has broad application prospects in the fields of catalysis, biosensors, molecular magnets, photoacoustic imaging, drug delivery, and photothermal therapy. Prussian blue has good biocompatibility, and there are related drugs on the market. In 2003, FDA approved Radiogardase, which uses insoluble Prussian blue as the active ingredient, for the treatment of cesium-137 and thallium radiation pollution. Oral administration, the dosage is 3-9g / day, and has good therapeutic effect. In addition, in recent years, further research by our researc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K47/32A61P39/06
CPCA61K33/26A61K47/32
Inventor 顾宁秦志国陈博杨芳
Owner SOUTHEAST UNIV
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