Application of diabetes vaccine based on (M)T-DC technology

Abstract

The invention relates to application of a diabetes vaccine based on an (M)T-DC technology. The specific single-epitope mutiple antigenic peptide in vitro sensitized dendritic cells are selected to obtain an autologous dendritic cell preparation to realize the combined use with mesenchymal stem cells; blood vessel endothelium injured cells are restored; the vaccine is used as a venous re-transfusion vaccine. The (M)T-DC technology is used for interfering and clearing blood vessel endothelium infection factors; the targeted deep going into local lesion parts can be realized; meanwhile, the mesenchymal stem cell treatment with the multipotential differentiation of a corresponding treatment course is matched for restoring the blood vessel endothelium and dissolving cicatrices, so that the treatment goal is achieved.

Description

technical field [0001] The invention relates to a vaccine, in particular to the application of a diabetes vaccine based on (M)T-DC technology. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion or insulin β-cell action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Severe cases can cause acute complications such as dehydration, electrolyte disturbance and acid-base imbalance, ketoacidosis and hyperosmolar coma. Drugs and diet are used in treatment, but it is difficult to achieve the desired effect. [0003] According to research, cytotoxin-associated protein (CagA), vacuolar toxin-associated protein (VacA), urease (Ure), cytomegalovirus (CMV), human papillomavirus (HPV-16), human papillomavirus (HPV- 18), herpes simplex v...

AI Technical Summary

Problems solved by technology

Long-term low-virulence infection will cause the immune system to gradually adapt to this infection. In the case of low immunity, the corresponding immune response cannot be caused against it, resulting in immune tolerance. The body cannot recognize the relevant pathogenic microorganisms, which will lead to pathogenic microorganisms. Long-term persistent infection, causing long-term damage to the body

[0004] This type of infection will cause serious pathological damage to the cardiovascular and cerebrovascular, and the continuous damage of vascular endothelial cells will cause diseases of the vascular system; the destruction of the vascular endothelium will form microthrombi, and the formation of microthrombi will block capillaries, resulting in the slow function of vascular cells. Regression, the progressive damage of blood vessels slowly accumulates, from quantitative deformation to qualitative change, once a breakthrough occurs, the damage to organ function is irreversible; it will lead to a decline in the function of the blood supply system, and damage to blood vessel function will lead to the occurrence of diseases such as diabetes

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