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A method for antibacterial modification of the surface of an implant material

A technology for surface antibacterial and implanted materials, applied in the field of biomaterials and multifunctional nanomaterials, which can solve problems such as bacterial resistance

Active Publication Date: 2021-01-01
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method still requires the use of a certain dose of antibiotics, which leads to a series of problems such as bacterial resistance

Method used

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  • A method for antibacterial modification of the surface of an implant material
  • A method for antibacterial modification of the surface of an implant material
  • A method for antibacterial modification of the surface of an implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: a kind of method for implant material surface antibacterial modification, comprises the steps:

[0028] (1) Slowly add 100ml of 0.03M methanol solution of sodium hydroxide into 100ml of 0.01M methanol solution of zinc acetate, heat to 60°C and stir for 2h;

[0029] (2) Repeat and evenly coat the solution prepared in step (1) on the surface of the titanium metal material by spin coating, and calcinate at 150° C. to ensure that the solid particles are attached to the surface of the material;

[0030] (3) Immerse the material prepared in step (2) in 100 mL of a mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethyleneimine, heat to 90°C, and react for 0.5-6h;

[0031] (4) After the reaction in step (3) is finished, the solution is naturally cooled to room temperature, then the material is taken out, washed with deionized water, and dried naturally;

[0032] (5) Dissolve 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenete...

Embodiment 2

[0035] Embodiment 2: a kind of method for implant material surface antibacterial modification, comprises the steps:

[0036] (1) Slowly add 100ml of 0.03M methanol solution of sodium hydroxide into 100ml of 0.01M methanol solution of zinc acetate, heat to 60°C and stir for 2h;

[0037] (2) Repeat and evenly coat the solution prepared in step (1) on the surface of the polymer polyurethane material by spin coating, and calcinate at 150° C. to ensure that the solid particles are attached to the surface of the material;

[0038] (3) Immerse the material prepared in step (2) in 100 mL of a mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethyleneimine, heat to 90°C, and react for 0.5-6h;

[0039] (4) After the reaction in step (3) is finished, the solution is naturally cooled to room temperature, then the material is taken out, washed with deionized water, and dried naturally;

[0040] (5) Dissolve 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethy...

Embodiment 3

[0043] Embodiment 3: a kind of method for implant material surface antibacterial modification, comprises the steps:

[0044] (1) Slowly add 100ml of 0.03M methanol solution of sodium hydroxide into 100ml of 0.01M methanol solution of zinc acetate, heat to 60°C and stir for 2h;

[0045] (2) Repeat and evenly coat the solution prepared in step (1) on the surface of the metal tantalum material by spin coating, and calcinate at 150°C to ensure that the solid particles are attached to the surface of the material;

[0046] (3) Immerse the material prepared in step (2) in 100 mL of a mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethyleneimine, heat to 90°C, and react for 0.5-6h;

[0047](4) After the reaction in step (3) is finished, the solution is naturally cooled to room temperature, then the material is taken out, washed with deionized water, and dried naturally;

[0048] (5) Dissolve 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetra...

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Abstract

The invention discloses an antibacterial modification method for a surface of an implant material. According to the invention, solid zinc oxide is taken as a raw material, the solid zinc oxide is modified on the surface of a metal implant material (titanium, tantalum, cobalt, chromium and molybdenum) and a high-molecular implant material (silica gel, polyurethane, polyether-ether-ketone and polylactic acid) by taking a cardiac pacemaker as a representative through simple steps. The method has the following obvious advantages that 1) a two-step system is firstly provided for preparing a solid zinc oxide coating which is different with a traditional single-layer material surface coating, the solid zinc oxide coating has excellent permanent antibacterial property, and realizes the long-actingantibiosis; and 2) the preparation method is simple, and can be widely used for clinical application.

Description

technical field [0001] The invention relates to the fields of biological materials and multifunctional nanometer materials, and mainly relates to a method for antibacterial modification of the surface of implanted materials such as cardiac pacemakers. Background technique [0002] Due to reasons such as population aging, sports injuries, and improvements in medical technology, the number of implant surgery cases is increasing year by year. However, with the increase in the frequency of clinical application of implant materials, there is also a hidden risk of increased postoperative infection cases. Implant material-related infection is a catastrophic complication of implant surgery, and it is also one of the main reasons for implant failure and even medical disputes. Among them, the infection of implanted devices (materials) represented by cardiac pacemakers is a typical example. When the device is taken out, the infected patient not only has to suffer huge economic losses ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L31/08
CPCA61L27/54A61L31/088A61L2300/102A61L2300/404A61L2300/602
Inventor 王小磊程细高缪新新廖航
Owner NANCHANG UNIV
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