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Preparation method of SERS-fluorescence double-mode metal reinforced substrate

A metal-enhanced, dual-mode technology, applied in the field of laser manufacturing technology and biosensing, can solve the problems of easy oxidation, poor biocompatibility, and low repeatability of the silver-plated layer on the metal substrate, and achieve good substrate biocompatibility. , economical, simple process effect

Active Publication Date: 2018-08-24
BEIHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the defects of low repeatability, incoherence, poor biocompatibility, and easy oxidation of the silver-plated layer of the metal substrate and the non-metallic substrate.

Method used

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  • Preparation method of SERS-fluorescence double-mode metal reinforced substrate
  • Preparation method of SERS-fluorescence double-mode metal reinforced substrate
  • Preparation method of SERS-fluorescence double-mode metal reinforced substrate

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preparation example Construction

[0033] Such as figure 1 As shown, the present invention provides a method for preparing a SERS-fluorescent dual-mode metal-enhanced substrate, comprising the following steps;

[0034] Step 1: Use multiple types of sandpaper to polish the surface of the substrate in sequence to remove the oxide layer, etc., so that the surface of the substrate is smooth and the surface roughness is less than 0.1 μm. Ultrasonic cleaning is performed on the polished substrate to remove surface impurities;

[0035] Step 2: Place the substrate on the workbench of the ultrashort pulse laser processing system, set the laser parameters, start the laser processing system, use the galvanometer to scan the laser repeatedly at a certain speed on the substrate, and finally obtain a three-dimensional microscopic image on the surface of the substrate. Nano periodic composite structure;

[0036] Step 3: Simple cleaning of the processed substrate.

[0037] Among them, step 1 uses 360, 600, 800, 1000, 2000, ...

Embodiment 1

[0040] (1) Take a TC4 substrate with an area of ​​10*10mm and a thickness of 2mm, clean it in absolute alcohol, use sandpaper to polish the surface to be processed in sequence, and then use ultrasonic cleaning for 20s.

[0041] (2) Place the TC4 substrate on the working platform of the femtosecond laser processing system (laser wavelength 1030nm, spot diameter 35μm, pulse width 800fs), set the laser parameters as laser power 2W, laser frequency 300KHz, scanning speed 1500mm / s , the number of scans is 15 times, the size of the scanning area is set to 800 μm × 800 μm, and the laser scanning route is a single-direction parallel line. Start the laser system to start processing.

[0042] (3) So far, the SERS-fluorescence dual-mode metal-enhanced processing of the three-dimensional micro-nano periodic composite structure based on TC4 is completed.

[0043] figure 2 It is a scanning electron microscope picture of a three-dimensional micro / nano periodic structure formed by the subs...

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Abstract

The invention discloses a SERS-fluorescence double-mode metal reinforced substrate and a preparation method of the SERS-fluorescence double-mode metal reinforced substrate. The preparation method comprises the following steps: (1) the surface of a substrate is polished by abrasive papers with multiple model numbers in sequence to remove an oxide layer and the like, so that the surface of the substrate is smooth, and the surface roughness is lower than 0.1 micron; and the polished substrate is ultrasonically cleaned to remove impurities on the surface; and (2) the substrate is positioned on a worktable of an ultrashort pulse laser processing system; laser parameters are set; a laser processing system is started; a galvanometer is used for scanning to enable laser to repeatedly scan on the substrate at a certain speed; and finally, a three-dimensional micronanometer periodical composite structure is obtained on the surface of the substrate. The preparation method is simple in process andlow in cost, has no need to add any reducing agent or surface active agent, and is high in stability and repeatability and suitable for large-scale commercial production.

Description

Technical field: [0001] The invention relates to a method for preparing a fluorescence-SERS dual-mode metal reinforcement substrate, belonging to the fields of laser manufacturing technology and biosensing. Background technique [0002] Fluorescence spectroscopy is an important tool for studying the structure of matter and the dynamics of matter at the molecular level, and has important applications in chemistry, biology and other disciplines. With the wide application of fluorescence testing technology, Metal Enhanced Fluorescence (MEF) spectroscopic technology developed based on nanotechnology has been used in the elimination of fluorescence self-quenching effect, single molecule detection, metal-based enhanced fluorescence probe and liquid phase. Metal-based enhanced fluorescence sensing platforms have been used in many fields. [0003] In addition to fluorescence spectroscopy, Raman spectroscopy is also widely used in material composition detection and molecular structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B23K26/00B23K26/352B23K26/60
CPCB23K26/352B23K26/60B23K26/0006B23K26/0624B23K26/082B23K26/355B23K26/3584B23K2101/36G01N21/648G01N21/658
Inventor 管迎春张佳茹卢立斌
Owner BEIHANG UNIV
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