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Vitamin C orally rapidly-disintegrating tablet

An oral disintegrating tablet and vitamin technology, applied in the field of medicine, can solve the problems of high production cost, prone to splits, poor disintegration performance, etc., and achieve the effects of low production cost, difficult to split, and high production efficiency

Inactive Publication Date: 2018-08-28
南京中生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the vitamin C orally disintegrating tablets disclosed in the prior art and their preparation methods have defects such as poor disintegration performance, prone to cracks during production, relatively complicated process, and high production cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Vitamin C preparation method:

[0026] (1) Weigh 10g of sweet tea powder and pass through a 100-120 mesh sieve for later use.

[0027] (2) Weigh 80g of acerola cherries and clean them, add sweet tea powder, and use a vibrating micro-pulverizer to pulverize at low-temperature intervals: 15 minutes each time, 5 minutes apart each time, and cycle 5 times.

[0028] (3) Take the pulverized product in step (2), extract it with microwave negative pressure, the extraction pressure is 0.25MPa, the temperature is 70°C, and the extraction time is 5min under 360W, and the extraction is continued for 3 times to obtain the extract.

[0029] (4) Ultrafiltering the extract through a hollow fiber membrane to obtain a filtrate.

[0030] (5) Concentrate the filtrate obtained in step (4) under reduced pressure at a low temperature of 50°C, and freeze-dry at -35°C to obtain vitamin C.

[0031] Party:

[0032] 132 parts of L-sodium ascorbate, 44 parts of L-ascorbic acid, 382 parts of sorb...

Embodiment 2

[0037] Vitamin C preparation method:

[0038] (1) Weigh 15g of sweet tea powder and pass through a 100-120 mesh sieve for later use.

[0039] (2) Weigh 100g of acerola cherries and clean them, add sweet tea powder, and use a vibrating micro-pulverizer to pulverize at low-temperature intervals: each pulverization takes 10 minutes, and each interval is 5 minutes, and the cycle is repeated 5 times.

[0040] (3) Take the pulverized product in step (2), extract it with microwave negative pressure, the extraction pressure is 0.20MPa, the temperature is 80°C, and the extraction time is 3min under 480W, and the extraction is carried out twice continuously to obtain the extract.

[0041] (4) Ultrafiltering the extract through a hollow fiber membrane to obtain a filtrate.

[0042] (5) Concentrate the filtrate obtained in step (4) under reduced pressure at 30°C, and freeze-dry at -40°C to obtain vitamin C.

[0043] Party:

[0044] 100 parts of sodium L-ascorbate, 40 parts of L-ascorbi...

Embodiment 3

[0049] Vitamin C preparation method:

[0050] (1) Weigh 10g of sweet tea powder and pass through a 100-120 mesh sieve for later use.

[0051] (2) Weigh 40g of acerola cherries and clean them, add sweet tea powder, and use a vibrating micro-pulverizer to pulverize at low-temperature intervals: 5 minutes each time, 5 minutes apart each time, and cycle 5 times.

[0052] (3) Take the pulverized product in step (2), extract it with microwave negative pressure, the extraction pressure is 0.15MPa, the temperature is 60°C, and the extraction time is 10min under 100W, and the extraction is continued for 3 times to obtain the extract.

[0053] (4) Ultrafiltering the extract through a hollow fiber membrane to obtain a filtrate.

[0054] (5) Concentrate the filtrate obtained in step (4) under reduced pressure at 60°C, and freeze-dry at -20°C to obtain vitamin C.

[0055] Party:

[0056] 150 parts of sodium L-ascorbate, 50 parts of L-ascorbic acid, 400 parts of sorbitol, 180 parts of mi...

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PUM

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Abstract

The invention discloses a vitamin C orally rapidly-disintegrating tablet. The vitamin C orally rapidly-disintegrating tablet is prepared from the following components in parts by weight: 100 to 150 parts of L-sodium ascorbate, 40 to 50 parts of L-ascorbic acid, 360 to 400 parts of sorbitol, 130 to 180 parts of microcrystalline cellulose, 10 to 20 parts of citric acid, 10 to 12 parts of silicon dioxide, 6 to 8 parts of magnesium stearate, 0.5 to 1 part of steviol glycoside and 6 to 8 parts of citrus sinensis essence. The invention discloses a method for extracting vitamin C from acerola cherryand sweet tea; the vitamin C is obtained by carrying out low-temperature micro-grinding, microwave extraction, vacuum concentration and freeze drying. The vitamin C orally rapidly-disintegrating tablet prepared by the invention has the advantages of safety, stability, effectiveness, good mouth feel, no irritation to mouth mucosa, good disintegration performance and low possibility of cracked tablets in the production. The preparation method provided by the invention has the advantages of simple operation, low production cost, high production efficiency, environment friendliness and suitabilityfor industrialized production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a vitamin C orally disintegrating tablet. Background technique [0002] Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin. Vitamin C in food is absorbed by the upper small intestine of the human body. Once absorbed, it will be distributed to all water-soluble structures in the body. There are about 1500mg of vitamin C in the metabolically active pool of vitamin C in a normal adult, and the highest storage peak is 3000mg of vitamin C. Vitamin C can prevent and treat scurvy, also known as "ascorbic acid". Studies have found that vitamin C can lower blood cholesterol levels, enhance immunity, increase capillary elasticity, promote wound and surgical incision healing, prevent colds, promote growth and development, prevent chronic mercury, lead and other metal poisoning, prevent aging, prevent tumors, etc. . [0003] Due to the wide range of effects...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K31/375A61P3/02C07D307/62
CPCA61K9/0056A61K9/2054A61K31/375A61P3/02C07D307/62A61K2300/00
Inventor 黄静徐彩萍
Owner 南京中生生物科技有限公司
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