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Compositions containing natural extracts and use thereof for skin and hair

A technology of composition and extract, applied in natural extract and pharmaceutical or cosmetic carrier, carrier or stabilization system, to reduce the graying process of mammalian hair, to reduce the appearance of non-pigmented skin areas in mammals, and to solve the problem of no Elderly people's nails and other problems

Pending Publication Date: 2018-08-31
SEIBERG CONSULTING LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there are no consumer products specifically for nail care for seniors, or for nail health in general

Method used

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  • Compositions containing natural extracts and use thereof for skin and hair
  • Compositions containing natural extracts and use thereof for skin and hair
  • Compositions containing natural extracts and use thereof for skin and hair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] This study evaluated the hydrogen peroxide decomposition activity of the test agents. Catalase Assay Kit was obtained from Cayman Chemical Co. (Ann Arbor, MI). This assay measures hydrogen peroxide elimination activity (e.g. catalase activity) using Purpald (4-amino-3-hydrazino-5-mercapto-1,2,4-triazole) as the chromogen in a colorimetric assay . The test involves a change in optical density (OD) at 540 nm, which is proportional to the effective activity present in the sample (based on reaction with methanol in the presence of hydrogen peroxide). Purpald, used as a chromogen, forms a bicyclic heterocycle with the resulting formaldehyde, which changes from colorless to purple after oxidation.

[0083] Native sample powders were suspended in water or PBS at 5% (w / v), sonicated to break down material into submicron particles, homogenized, and centrifuged at 1,000 RPM for 10 minutes to remove insoluble material. Serial dilutions were prepared for each test material and m...

Embodiment 2

[0092] This study evaluated the effect of the test material on the endogenous cellular hydrogen peroxide degradation and elimination activity of cultured normal human keratinocytes. Hydrogen peroxide degradation was measured using protein lysates of treated cells using Purpald (4-amino-3-hydrazino-5-mercapto-1,2,4-triazole) as the chromogen in a colorimetric assay active. The test involves a change in optical density (OD) at 540 nm that is proportional to the effective activity (based on reaction with methanol in the presence of hydrogen peroxide) present in the sample. Purpald, used as a chromogen, forms a bicyclic heterocycle with the resulting formaldehyde, which changes from colorless to purple after oxidation.

[0093]Sample powders of native test reagents were suspended in phosphate buffered saline (1xPBS) at 5% w / v and homogenized by sonication. After spinning at 1000 RPM for 10 min, the supernatant was sterilized by filtration using a 0.2 μm syringe filter.

[0094]...

Embodiment 3

[0104] The aim of this study was to evaluate the intracellular antioxidant activity of the test material in cultured human epidermal keratinocytes in response to hydrogen peroxide injury. Cells were treated with test material, labeled with H2DCFDA and subsequently exposed to hydrogen peroxide. Relative fluorescence was measured as an indication of intracellular reactive oxygen species (ROS). The test involves a change in fluorescence that is directly proportional to the effective intracellular antioxidant activity compared to untreated and hydrogen peroxide-only treated samples.

[0105] Test reagents were stored at room temperature until use. Suspend the sample powder in phosphate buffered saline (1xPBS) to prepare a 10 mg / mL (1% w / v) stock solution, vortex for 1 min, and sonicate at 30-50% output for 10 min on ice at 4 °C Centrifuge at 1000 rpm for 10 minutes and sterilize the supernatant with a 0.2 μm syringe filter. Prepare this homogenized solution for each test materi...

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Abstract

The present disclosure relates to compositions containing a natural extract(s) and their fraction(s) and the use of such compositions for treatment of skin, hair and nail. For example, the present disclosure relates to compositions containing an aqueous extract of (i) Yacon leave, (ii) Amor Seco leave, or (iii) Porphyridium biomass, or a combination thereof and a pharmaceutically or cosmetically acceptable carrier use on hair skin and nails for cosmetic purposes.

Description

Background technique [0001] Graying of the hair (greying), or a decrease in pigment production and deposition in the hair shaft, is a visible sign of aging and in many cases is highly undesirable. Hair graying is a complex phenomenon caused by the interaction of multiple intrinsic and extrinsic factors. Intrinsic factors can include genetically programmed processes, genetic diseases, and intrinsic aging processes that may lead to premature graying. Extrinsic factors can include environmental factors (such as wind, heat, cigarette smoke, chemicals, ultraviolet radiation, etc.), nutritional effects, drug effects, and emotional stress. All these elements induce molecular and cellular processes that lead to the loss of hair hypopigmentation. [0002] The main solution to hair graying is hair dyeing ("dying"), which has been documented archaeologically since 1500 BC and is still popular today. However, hair coloring has various limitations. As the hair grows, the borders of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00
CPCA61Q5/10A61Q19/04A61K36/04A61K36/28A61K36/48A61K2800/5922A61K2800/782A61K8/9717A61K8/9789A61P17/00A61P17/02A61P17/04A61P17/16A61P17/18A61P39/06A61P43/00A61K2300/00A61K8/60A61Q19/02A61K2236/331A61K8/447A61K8/062A61K8/34A61K8/345A61K8/347A61K8/41A61K8/46A61K8/676A61K8/732A61K8/8147A61K8/88A61K8/891A61K8/922A61K2800/48A61K2800/51A61K2800/522A61K2800/524A61K2800/594A61Q5/00
Inventor M.赛贝格
Owner SEIBERG CONSULTING LLC
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