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Application of extract of dalbergia pinnata in preparing drug for healing skin wound

A skin wound and extract technology, applied in the field of medicine, can solve the problems of no research report on the extraction method and use of the alcohol extract of oblique leaf sandalwood, and achieve the effects of promoting the proliferation of vascular endothelial cells, accelerating the healing speed and having broad prospects.

Inactive Publication Date: 2018-09-11
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the extraction method and application of the alcoholic extract of sandalwood oblique leaf

Method used

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  • Application of extract of dalbergia pinnata in preparing drug for healing skin wound
  • Application of extract of dalbergia pinnata in preparing drug for healing skin wound
  • Application of extract of dalbergia pinnata in preparing drug for healing skin wound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present embodiment provides the preparation method of sandalwood oblique leaf extract, and the steps are as follows:

[0028] Crush 1 kg of oblique-leaved sandalwood cane, pass through a 20-mesh sieve, add 5000 mL of ethanol solution with a mass concentration of 95% and ultrasonically extract twice, each extraction time is 2 hours, filter, and combine the filtrates at -0.07 MPa at a temperature of Ethanol is recovered under reduced pressure at 50°C, concentrated to an extract, and then vacuum-dried at 60°C to obtain the Sandalwood oblique leaf extract of the present invention.

[0029] According to the method for determining the total flavonoid content specified in the 2015 edition of the Chinese Pharmacopoeia, the total flavonoid content in the Sandalwood oblique leaf extract was measured, and the total flavonoid content in the Sandalwood oblique leaf extract obtained under the extraction method was 20.8%.

Embodiment 2

[0030] Example 2 Preparation of cataplasm of sandalwood oblique leaf extract

[0031] Weigh 0.8g of CMC-Na, add an appropriate amount of purified water, heat and dissolve in a water bath to make a 20% solution, add an appropriate amount of glycerin, stir well, and form A phase; prepare 10% PVA aqueous solution and 10% gelatin aqueous solution by the same method, respectively Phase B and Phase C: first mix Phase B and Phase C, then add to Phase A, stir evenly, add finely powdered silica gel and preheated sandalwood extract, and apply it on the non-woven fabric while it is hot. Place it in an electric constant temperature drying oven, and dry it at 70°C for 2 hours to obtain a poultice of Sandalwood oblique leaf extract.

Embodiment 3

[0032] Embodiment 3 preparation of sandalwood oblique leaf extract gel

[0033] Weigh 2.5g of Carbomer-940, moisten it with 11mL of glycerin and add 60mL of distilled water to swell, leave it overnight at room temperature for later use (I); weigh 5g of Sandalwood oblique leaf extract, add absolute ethanol to dissolve it completely, and set aside for later use (II) ;Weigh 20g of urea, add 20mL of distilled water to dissolve, and set aside (Ⅲ); Mix I, II, and III, slowly add 1.0g of Tween-80, add an appropriate amount of triethanolamine to adjust the pH value to 7.0, and finally add distilled water to 200g, stir Uniform, degassed, sterilized, potted, that is.

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Abstract

The invention provides application of an extract of dalbergia pinnata in preparing a drug for skin wound healing. The extract can promote formation of wound capillaries and collagenous fibers and shorten the healing time of the skin wound, and has the effects of reducing inflammation and increasing the skin recovering degree; after the extract is applied to the skin with the wound, the skin is smooth after healing and has no scar, and the healing effect is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an extract of sandalwood oblique leaf in the preparation of skin wound healing medicine. Background technique [0002] The skin is the largest immune organ in the human body and plays an important role in resisting external pathogenic stimuli. Human skin is often directly exposed to the presence of harmful biological, thermal, mechanical or chemical agents and is therefore extremely vulnerable to trauma. The skin wound repair process can be roughly divided into three stages: inflammation stage, value-added stage and tissue remodeling stage. In clinical practice, skin wounds are often treated by speeding up wound healing, preventing bacterial infection, reducing pain caused by bleeding, inflammation, wound infection, and ulcers, preventing negative effects of trauma on physiological functions, and ensuring the appearance of wounds after healing. ...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P17/02
CPCA61K36/48A61P17/02
Inventor 张丹雁梁耀勇赵维波熊清平马换换
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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