Enzyme-driven bottle-shaped nanomotor and preparation method thereof
A bottle-shaped, nano-technology, applied in the field of medical biomaterials, can solve problems such as difficult positioning and control, poor controllability, toxic and side effects, etc.
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Embodiment 1
[0048] See figure 1 , figure 2 , image 3 ,
[0049] figure 1 It is the schematic diagram of the enzyme-driven bottle-shaped nanomotor swimming in this embodiment;
[0050] figure 2 It is an optical microscope photo of enzyme-driven bottle-shaped nanomotor moving under chemical drive in the present embodiment;
[0051] image 3 It is an optical microscope photo of the enzyme-driven bottle-shaped nanomotor chemotactic movement under the glucose concentration gradient prepared in this example.
[0052] This embodiment provides an enzyme-driven bottle-shaped nanomotor, which includes a bottle-shaped nanoparticle skeleton and two enzymes inside the skeleton. Wherein the bottle-shaped nanoparticles are hydrothermally carbonized carbon-based polymers, and the two enzymes are glucose oxidase and catalase. Moreover, the glucose oxidase and catalase used in this example are commercially available products, wherein the glucose oxidase can decompose glucose, convert the chemical ...
Embodiment 2
[0060] See Figure 4 , Figure 5 ,
[0061] Figure 4 It is a schematic diagram of step 3 and step 4 in the preparation method of the enzyme-driven bottle-shaped nanomotor in this embodiment;
[0062] Figure 5 It is a transmission electron microscope photo and an energy dispersive X-ray detection photo of the enzyme-driven bottle-shaped nanomotor prepared in this example.
[0063] In this example, using bottle-shaped nanoparticles, glucose oxidase, and catalase as materials, glucose oxidase and catalase are simultaneously loaded inside the bottle-shaped nanoparticles by vacuum infusion and ultrasonic infusion to prepare a Enzyme-driven bottle-shaped nanomotors. Specifically include the following steps:
[0064] Step 1. Preparation of bottle-shaped nanoparticles:
[0065] a. Add 0.0435 g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer (P123) and 0.0365 g of sodium oleate (SO) into 20 mL of deionized water to obtain mixed solution A, and ...
Embodiment 3
[0081] In this example, using bottle-shaped nanoparticles, glucose oxidase, and catalase as materials, glucose oxidase and catalase are simultaneously loaded inside the bottle-shaped nanoparticles by vacuum infusion and ultrasonic infusion to prepare a Enzyme-driven bottle-shaped nanomotors. Specifically include the following steps:
[0082] Step 1. Preparation of bottle-shaped nanoparticles:
[0083] a. Add 0.0435 g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer (P123) and 0.0365 g of sodium oleate (SO) into 10 mL of deionized water to obtain mixed solution A, And stir at 100 rpm for 0.5 h in a water bath at 25 °C;
[0084] b. Dissolve 2 g of ribose in 20 mL of deionized water, and add it to the mixed solution A, and stir at a speed of 100 rpm for 20 min in a water bath at a temperature of 25 °C to obtain a mixed solution B;
[0085] c. Transfer the mixed solution B to a 75 mL reactor, put it in an oven, keep it at 160 °C for 8-20 h, and ce...
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