Pharmaceutical composition to prevent and treat diabetic nephropathy and preparation method thereof

A technology for diabetic nephropathy and composition, applied in the field of medicine, can solve problems such as unrecorded drug dosage and the like

Inactive Publication Date: 2018-09-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the classic Tibetan medicine "Sibu Medical Code" only records the names of the medicinal flavors of the prescription, "there is no amount of medicine", and does not record the dosage of specific medicines. The prescription dosages recorded in later generations of Tibetan medicine drug standards are also different. Further research on the prescription dose and mechanism of action for diabetic nephropathy, in order to guide the clinical medication of Tibetan medicine

Method used

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  • Pharmaceutical composition to prevent and treat diabetic nephropathy and preparation method thereof
  • Pharmaceutical composition to prevent and treat diabetic nephropathy and preparation method thereof
  • Pharmaceutical composition to prevent and treat diabetic nephropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0041] 1. Extraction process

[0042] Prescription: 3 parts of turmeric, 10 parts of barberry bark, 3 parts of emblica, and 6 parts of Tribulus terrestris.

[0043] Add water to extract the above four flavors three times, add 12 times the amount of water for the first time, soak for 1 hour, decoct for 1 hour, filter, add water and decoct twice, add 10 times the amount of water each time, 1 hour each time, combine The filtrate was concentrated to the desired concentration.

[0044] 2. Quality control

[0045] HPLC method for the determination of gallic acid, ellagic acid, magnolialine, berberine hydrochloride, jatrorrhizine hydrochloride, palmatine hydrochloride and curcumin in Tibetan medicine Siwei Jianghuang Decoction Powder:

[0046] Using Capcell Pak C18-MGⅡ (4.6mmI.D.×250mm, 5μm), mobile phase A is acetonitrile, mobile phase B is 0.1% phosphoric acid aqueous solution; flow rate...

Embodiment 2

[0048] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0049] 1. Extraction process

[0050] Prescription: 3 parts of turmeric, 6 parts of barberry bark, 3 parts of emblica, and 6 parts of Tribulus terrestris.

[0051] Add water to extract the above four flavors three times, add 12 times the amount of water for the first time, soak for 1 hour, decoct for 1 hour, filter, add water and decoct twice, add 10 times the amount of water each time, 1 hour each time, combine The filtrate was concentrated to the desired concentration.

[0052] 2. Quality control

[0053] With embodiment 1.

Embodiment 3

[0054] Example 3 HPLC Determination of Contents of 7 Components in Tibetan Medicine Siwei Jianghuang Tang Powder

[0055] 1. Materials and instruments

[0056] 1.1 Instrument

[0057] HPLC chromatograph (Agilent 1260 type, equipped with online degasser, automatic sampler, diode array detector, column thermostat, American Agilent);

[0058] Column: Capcell Pak C 18 -MGⅡ (4.6mm×250mm, 5μm, Shiseido, Japan); U-Pure Water Manufacturing System (Model: UPH-I-10T, Chengdu Ultrapure Technology Co., Ltd.).

[0059] Blood glucose meter (ACCCU-CHEK Performa) (Roche Excellence, supporting blood glucose test strips and disposable blood collection needles, produced by Roche Diagnostic Products (Shanghai) Co., Ltd.);

[0060] Full-wavelength multi-function reader (VARIOSKAN FLASH 2.4.3, American Thermo Company);

[0061] Constant temperature culture shaker (ZHWY-100H, Shanghai Zhicheng Analytical Instrument Manufacturing Co., Ltd.);

[0062] Radio microscope (H-600IV, Hitachi, Japan). ...

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Abstract

The invention discloses a pharmaceutical composition to prevent and treat diabetic nephropathy, characterized by being prepared from, by weight, 1-15 parts of common turmeric rhizome, 1-8 parts of bark of Berberis kansuensis, 1-15 parts of fruit of emblic leafflower and 1-8 parts of puncturevine caltrap fruit. The medicinal results of the four-herb turmeric decoction under different combination doses for rats with diabetic nephropathy are observed and are combined with principal component analysis to dig the optimal combination of the four-herb turmeric decoction that is effective in intervening early diabetic nephropathy; the clinical application of the decoction and development of new drugs are promoted.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating diabetic nephropathy and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is one of the most common chronic complications of diabetes and the main cause of end-stage renal failure. Therefore, early prevention and treatment of DN is particularly important. DN belongs to the category of "Jingni Saku" disease (Chinese translation: frequent urination) in Tibetan medicine. 1. Depletion of physical energy is the essential feature of the disease. The specific treatment method is to use "Yongwaxi Decoction" (the four-flavored Tibetan medicine prescription of Berberis bark, turmeric, emblica, and Tribulus terrestris, which is the source of the prescription of the modern preparation "Siwei Jianghuang Tang San") decoction orally, and the four-flavored turmeric soup The syndrome of atten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P13/12A61P3/10G01N30/02G01N30/06
CPCA61K36/185A61K36/29A61K36/47A61K36/9066G01N30/02G01N30/06A61K2300/00
Inventor 赖先荣曾勇范刚
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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