Pharmaceutical composition to prevent and treat diabetic nephropathy and preparation method thereof
A technology for diabetic nephropathy and composition, applied in the field of medicine, can solve problems such as unrecorded drug dosage and the like
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Embodiment 1
[0040] The preparation of embodiment 1 pharmaceutical composition of the present invention
[0041] 1. Extraction process
[0042] Prescription: 3 parts of turmeric, 10 parts of barberry bark, 3 parts of emblica, and 6 parts of Tribulus terrestris.
[0043] Add water to extract the above four flavors three times, add 12 times the amount of water for the first time, soak for 1 hour, decoct for 1 hour, filter, add water and decoct twice, add 10 times the amount of water each time, 1 hour each time, combine The filtrate was concentrated to the desired concentration.
[0044] 2. Quality control
[0045] HPLC method for the determination of gallic acid, ellagic acid, magnolialine, berberine hydrochloride, jatrorrhizine hydrochloride, palmatine hydrochloride and curcumin in Tibetan medicine Siwei Jianghuang Decoction Powder:
[0046] Using Capcell Pak C18-MGⅡ (4.6mmI.D.×250mm, 5μm), mobile phase A is acetonitrile, mobile phase B is 0.1% phosphoric acid aqueous solution; flow rate...
Embodiment 2
[0048] The preparation of embodiment 2 pharmaceutical compositions of the present invention
[0049] 1. Extraction process
[0050] Prescription: 3 parts of turmeric, 6 parts of barberry bark, 3 parts of emblica, and 6 parts of Tribulus terrestris.
[0051] Add water to extract the above four flavors three times, add 12 times the amount of water for the first time, soak for 1 hour, decoct for 1 hour, filter, add water and decoct twice, add 10 times the amount of water each time, 1 hour each time, combine The filtrate was concentrated to the desired concentration.
[0052] 2. Quality control
[0053] With embodiment 1.
Embodiment 3
[0054] Example 3 HPLC Determination of Contents of 7 Components in Tibetan Medicine Siwei Jianghuang Tang Powder
[0055] 1. Materials and instruments
[0056] 1.1 Instrument
[0057] HPLC chromatograph (Agilent 1260 type, equipped with online degasser, automatic sampler, diode array detector, column thermostat, American Agilent);
[0058] Column: Capcell Pak C 18 -MGⅡ (4.6mm×250mm, 5μm, Shiseido, Japan); U-Pure Water Manufacturing System (Model: UPH-I-10T, Chengdu Ultrapure Technology Co., Ltd.).
[0059] Blood glucose meter (ACCCU-CHEK Performa) (Roche Excellence, supporting blood glucose test strips and disposable blood collection needles, produced by Roche Diagnostic Products (Shanghai) Co., Ltd.);
[0060] Full-wavelength multi-function reader (VARIOSKAN FLASH 2.4.3, American Thermo Company);
[0061] Constant temperature culture shaker (ZHWY-100H, Shanghai Zhicheng Analytical Instrument Manufacturing Co., Ltd.);
[0062] Radio microscope (H-600IV, Hitachi, Japan). ...
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