Floccularia luteovirens polysaccharide as well as preparation method thereof and medical use thereof in controlling diabetes
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A technology of mushroom polysaccharides and yellow-green rolls, which is applied in medical preparations containing active ingredients, urinary system diseases, applications, etc., can solve the problems of blank and lack of chemical ingredients, and achieve simple extraction process, less toxic and side effects, and significant Anti-oxidative stress and anti-inflammatory effects
Inactive Publication Date: 2018-09-25
JILIN AGRICULTURAL UNIV
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Problems solved by technology
At present, the research on Pleurotus pubescens mainly focuses on taxonomy, liquid fermentation conditions, and nutritional composition analysis. The research on its chemical composition and pharmacological effects is still blank, and there is a lack of research on its polysaccharides. In addition, for diabetic nephropathy The therapeutic effect has not been reported yet
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Embodiment 1
[0029] Put 1 kg of fruiting bodies of the yellow-green Pleurotus pubescens in a drying box, dry at 55°C to constant weight, crush, sieve, and use the classic water extraction and alcohol precipitation method, add 10kg of distilled water to the sieved powder, and heat it in hot water at 50°C Extract for 1h, centrifuge at 5500r / min for 15min, extract twice, combine the supernatant, use 0.1% papain and Sevag reagent to remove protein, dialyze, freeze-dry at low temperature in vacuum for 48 hours to obtain dry powder, freeze-dry at low temperature in vacuum After 48 hours, a dry powder was obtained.
Embodiment 2
[0031] Place 5kg of yellow-green Pleurotus fruiting bodies in a drying oven, dry to constant weight, crush, sieve, adopt the traditional water extraction and alcohol precipitation method, add 40kg of distilled water to the sieved powder, and soak in hot water at 70°C Extract for 4 h, centrifuge at 5500r / min for 15min, extract twice, combine the supernatant, use 0.1% papain and Sevag reagent to remove protein, dialyze, freeze-dry at low temperature in vacuum for 48 hours, and obtain dry powder.
Embodiment 3
[0033] Put 10kg of yellow-green mushroom fruiting bodies in a drying box, dry to constant weight, crush, sieve, adopt the traditional water extraction and alcohol precipitation method, add 60kg of distilled water to the sieved powder, and soak in hot water at 100°C Extract for 6 h, centrifuge at 5500r / min for 15min, extract twice, combine the supernatant, use 0.1% papain and Sevag reagent to remove protein, dialyze, freeze-dry at low temperature in vacuum for 48 hours, and obtain dry powder.
[0034] Further prove that the present invention is used in the prevention, improvement or treatment of diabetes mellitus by following tests:
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Abstract
The invention provides floccularia luteovirens polysaccharide as well as a preparation method thereof and a medical use thereof in controlling diabetes. Crude polysaccharide obtained by water extraction and alcohol precipitation of floccularia luteovirens is subjected to protein removal to obtain any one or more of floccularia luteovirens total sugar, floccularia luteovirens protein composite, floccularia luteovirens polysaccharide or purified homogeneous polysaccharide component. According to the animal experiment, the floccularia luteovirens polysaccharide can reduce bodyweight growth speedof a db/db mouse, reduces fasting blood-glucose of a diabetic mouse, improves oral glucose tolerance, and has good activity of reducing blood fat, resisting oxidization and resisting inflammation. Thefloccularia luteovirens polysaccharide is taken as a natural product obtained from an edible and medicinal fungus resource, is small in toxic and side effect, has remarkable effects of resisting oxidative stress and inflammation, realizing the effects of resisting type 2 diabetes and renal complications, further can be used for developing medicines and healthcare products for safely and effectively preventing, alleviating or treating type 2 diabetes and renal complications caused by diabetes, and has an extremely high edible value, an extremely high medical value and an extremely high economical value.
Description
technical field [0001] The invention discloses a polysaccharide of yellow-green mushroom, and provides its preparation method; the invention further discloses the medical application of the polysaccharide of yellow-green mushroom in the prevention and treatment of diabetes, which can be used to prevent and treat type II diabetes and diabetic nephropathy A medicine or a health care product belongs to the technical field of traditional Chinese medicine. Background technique [0002] Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and abnormal blood lipids that can affect tissues and organs throughout the body. Blood lipids and dietary interventions. Although the conditions of patients with diabetes and diabetic nephropathy have been controlled and alleviated after treatment with drugs and other methods, the damage to tissue cells such as the kidney cannot be completely restored. Therefore, it is particularly important to find ...
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