Star-shaped polymer containing lipoyl group at the end, preparation method thereof, polymer nanoparticle prepared therefrom and application thereof

Abstract

The invention discloses a star-shaped polymer containing a lipoyl group at the end, a preparation method thereof, polymer nanoparticles prepared therefrom and applications thereof. The star-shaped polymer containing lipoyl group in the side chain is obtained by esterification. The degree of LA substitution is controllable and has excellent biocompatibility. It can be used to control the drug release system, and the prepared cancer-targeted reduction-sensitive reversible cross-linked polymer Nano-particles and nano-drugs support stable long-term circulation in the body, but are highly enriched in cancer tissues and efficiently enter cells, quickly de-crosslink and release drugs in cells, efficiently and specifically kill cancer cells, and effectively inhibit the growth of cancer without causing toxic side effects.

Description

Technical field

[0001] The invention relates to a biocompatible polymer material and its application, in particular to a star-shaped biocompatible polymer containing lipoyl groups at the end, a preparation method thereof, polymer nanoparticles prepared therefrom, and a target The application to nanomedicine belongs to the field of medical materials. Background technique

[0002] Polymer materials with good biocompatibility and biodegradability have been widely used in the fields of biomedicine, including tissue engineering and drug controlled release. Nanomedicine based on this has shown good application prospects, but the existing The polymer nanomedicine prepared by technology has the problems of unstable circulation in the body, low uptake by tumor cells, low intracellular drug concentration, and slow intracellular drug release speed, resulting in low drug efficacy of nanomedicine and toxic side effects caused by drug leakage. ; For example, the results of BIND-014 in clinica...

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