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Bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application

A technology of bear bile powder and bear bile, applied in the preparation of bear bile powder, Senbao bear bile powder field, can solve the problems of many impurities, extremely fishy taste, easy to be corrupted, etc.

Inactive Publication Date: 2018-10-16
齐光伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] CN1311002A (00102073.0, Shi Lixia) discloses a refined bear bile powder and its preparation method, which belongs to the field of pharmacy. Common bear bile powder is easy to absorb moisture and agglomerate, has a sticky tooth feeling, extremely fishy smell, extremely bitter taste, many impurities, and slow absorption. The property is unstable and easy to be corrupted, and the content of active ingredients is low, which limits the application range of bear bile powder. Oral application often adds flavoring agents to reduce the stench

Method used

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  • Bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application
  • Bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application
  • Bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Example 1: Preparation of bear bile powder

[0101] (1) Filter the bear bile collected by the tubeless drainage method to obtain the filtrate, and dilute it with 0.75 times the amount of water to obtain the bear bile liquid. Let it stand for 12 hours at a temperature of 2-6°C, and then perform subsequent operations;

[0102] (2) Fill the bear bile liquid obtained in step (1) with nitrogen gas for 27 minutes and then carbon dioxide for 18 minutes by means of bubbling;

[0103] (3) Pour the bear bile liquid treated by the above operation into the material tray (liquid layer depth 1.5 ~ 2.5cm), immediately put it in a freeze dryer pre-frozen to -50 ℃, freeze for 3.5 hours; then Raise the temperature to -22°C at a rate of 0.3°C and hold for 1 hour; then raise the temperature to -3°C at a rate of 0.3°C per minute and hold for 2.5 hours; then heat up to 10°C at a rate of 0.3°C per minute and hold for 4.5 hours; then Raise the temperature to 32°C at a rate of 0.3°C per minute and ke...

Embodiment 2

[0111] Example 2: Preparation of bear bile powder

[0112] (1) Filter the bear bile collected by the tubeless drainage method to obtain the filtrate, and dilute it with 0.5 times the amount of water to obtain the bear bile liquid, and let it stand for 12 hours at a temperature of 2-6°C before proceeding with subsequent operations;

[0113] (2) Fill the bear bile liquid obtained in step (1) with nitrogen for 30 minutes and then carbon dioxide for 15 minutes by means of bubbling;

[0114] (3) Pour the bear bile liquid treated by the above operation into the material tray (liquid layer depth 1.5 ~ 2.5cm), immediately put it in a freeze dryer pre-frozen to -55 ℃, freeze for 3 hours; then every minute Increase the temperature to -23°C at a rate of 0.3°C and hold for 1.5 hours; then increase the temperature to -2°C at a rate of 0.25°C per minute and hold for 2 hours; then increase the temperature to 12°C at a rate of 0.25°C per minute and hold for 5 hours; then Increase the temperature t...

Embodiment 3

[0122] Example 3: Preparation of bear bile powder

[0123] (1) Filter the bear bile collected by the tubeless drainage method to obtain the filtrate, dilute with 1 times the amount of water to obtain the bear bile liquid, and let it stand for 12 hours at a temperature of 2-6°C before proceeding with subsequent operations;

[0124] (2) Fill the bear bile liquid obtained in step (1) with nitrogen gas for 25 minutes and then carbon dioxide for 20 minutes by means of bubbling;

[0125] (3) Pour the bear bile liquid processed by the above operation into the material tray (liquid layer depth 1.5 ~ 2.5cm), immediately put it in a freeze dryer pre-frozen to -45 ℃, freeze for 4 hours; then every minute Increase the temperature to -20°C at a rate of 0.35°C and hold for 1.2 hours; then increase the temperature to -2°C at a rate of 0.35°C per minute and hold for 3 hours; then increase the temperature to 15°C at a rate of 0.34°C per minute and hold for 4 hours; then Increase the temperature to ...

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Abstract

The invention discloses bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application. The bear gall powder can be used for adjusting blood fat, reducing total cholesterol, preventing cardiovascular and cerebrovascular diseases and preventing atherosclerosis; the invention discloses a preparation method of the bear gall powder and the bear gall powder obtained through the method. In a bear gall powder preparation process, materials are subjected to ice crystallization, then freeze drying is conducted, and the obtained freeze dried bear gall powder can be called ice crystal state bear gall powder or can be called ice crystal bear gall powder; especially, the bear gall powder which can be called Senbao bear gall powder does not contain any auxiliaries or chemical additives; especially, the ice crystal state bear gall powder not only can more effectively adjust the blood fat and reduce the total cholesterol, but also can be more effectively used for preventing the cardiovascular and cerebrovascular diseases, preventing atherosclerosis and preventing and treating solid tumors and hematological system tumors, and more especially, the ice crystal state bear gall powder can be effectively used for inhibiting thrombosis, inhibiting platelet aggregation and preventing cerebral ischemia and ischemic encephalopathy.

Description

Technical field [0001] The invention belongs to the technical field of medical and health products, relates to a bear bile powder prepared by a specific process, and also relates to a preparation method of the bear bile powder. In the present invention, the material is ice-crystallized during the preparation process of bear bile powder and then freeze-dried, and the prepared bear bile powder exhibits excellent technical effects, especially in terms of physical and chemical properties. In particular, in the present invention, the bear bile powder is diluted with a small amount of water in advance, filled with two gases, and then deep-frozen, so that the active ingredients contained in the bear bile are in a state of ice crystals, followed by sublimation, and the resulting freeze-dried Bear bile powder can be referred to as ice crystal bear bile powder, or ice crystal bear bile powder, or Sambo bear bile powder in the present invention. In particular, the bear bile powder which c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P7/02A61P9/10A23L33/10
CPCA23V2002/00A61K35/413A23L33/10A61P7/02A61P9/10A23V2200/326
Inventor 齐光伟
Owner 齐光伟
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