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Pharmaceutical composition containing chemical ablating agent and vaccine adjuvant, and application thereof

A vaccine adjuvant and composition technology, which can be applied in the directions of drug combinations, active ingredients of heterocyclic compounds, and medical preparations containing active ingredients, etc., can solve the problems of high recurrence rate and low curative effect of intractable diseases related to local lesions, etc., Achieving the effect of low cost, small systemic side effects, and rapid reduction

Inactive Publication Date: 2018-10-23
CHENGDU KUACHANG SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, absolute ethanol still shows very low efficacy against liver tumors larger than 5 cm in diameter
And in general, the recurrence rate of local lesion-related diseases, especially intractable diseases, treated by the existing chemical ablation therapy is high

Method used

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  • Pharmaceutical composition containing chemical ablating agent and vaccine adjuvant, and application thereof
  • Pharmaceutical composition containing chemical ablating agent and vaccine adjuvant, and application thereof
  • Pharmaceutical composition containing chemical ablating agent and vaccine adjuvant, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0188] Embodiment 1: the preparation of composition

[0189] 1. Preparation of liquid preparations

[0190] Using the aforementioned preparation method, the composition of the part of the pharmaceutical composition solution of the present invention prepared in this embodiment is listed in Table 2. The excipients therein include vehicles, and unless otherwise specified, all vehicles contain water for injection. The pharmaceutical composition solutions are all stored for more than 2 hours after preparation and used again.

[0191] Table 2

[0192]

[0193]

[0194]*: The vehicle is an aqueous solution containing 25% ethanol, 15% PEG300 and 15% propylene glycol.

[0195] Specifically, for example, based on the final 100ml composition solution volume, at room temperature, measure the corresponding chemical ablative agent (such as methylene blue or / and quinine dihydrochloride) and aluminum hydroxide according to the amount shown in Table 2 Add the dry powder of microparti...

Embodiment 2

[0204] Example 2: Synergy Research

[0205] 1. Research on collaborative conditions

[0206] One for mice bearing S180 cells (118mm 3 ) experiments, the successfully modeled test animals were randomly divided into negative control group and research group. The negative control group was intratumorally injected with 100 μl of normal saline, and the four study groups (groups A, B, C, and D) were injected intratumorally with 5 methylene blue / aluminum hydroxide particle compositions. In the composition, the concentration of methylene blue is 2%, and the concentration of aluminum hydroxide particles is 0%, 0.1%, 0.5%, and 1%, respectively. The research drugs are all suspensions prepared according to the preparation method of Example 1 with water for injection as the vehicle. The dose of methylene blue is 100mg / kg animal. Medication was administered once, and the animals were euthanized and dissected 21 days after the administration. Figure 1 (1-1 and 1-2) shows the effect of c...

Embodiment 3

[0227] Embodiment 3: super effective activity research

[0228] Activity is actually a relative concept. Within the scope of the present invention, the term "activity" refers to the property of a substance showing a certain therapeutic effect, the term "effective activity" refers to the property of a substance having a therapeutic effect equivalent to existing clinical drugs, and the term "super-effective activity" "Refers to the property that a substance has significantly higher therapeutic effects compared with existing clinical drugs. Taking existing clinical anti-tumor chemotherapeutic drugs (such as 5-fluorouracil) as an example, their tumor inhibition rate in the tumor-bearing mouse test is 45-75%. Taking existing clinical anti-tumor immune drugs (such as autologous tumor vaccines) as an example, their tumor-inhibitory rate in the tumor-bearing mouse test is 45-80%. This is the curative effect of existing clinical medicine. Hyperpotent activity requires significantly ...

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Abstract

The invention relates to a pharmaceutical composition containing a chemical ablating agent and a vaccine adjuvant and having chemical ablation and immunological effect, and application of the pharmaceutical composition to preparation of drugs used for preventing and treating diseases related to local lesion of mammals.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising a chemical ablation agent and a vaccine adjuvant, having chemical ablation and immune effects, the use of the composition in the preparation of medicines for the prevention and treatment of diseases related to local lesions in mammals, and the use of It is a method for preventing and treating local lesion-related diseases in mammals. Background technique [0002] For the treatment of diseases related to local lesions in mammals, especially intractable diseases, such as malignant tumors, intractable inflammation, intractable microbial infections, intractable skin diseases, etc., still mainly rely on such as surgery, chemotherapy and radiotherapy. It is so stubborn not only because it is difficult to treat, but also because there are many recurrences even after effective treatment by these therapies. [0003] Classical chemotherapy is usually carried out by delivering specific and ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K33/08A61P35/00A61K31/5415A61K31/49A61K31/60
CPCA61K31/49A61K31/5415A61K31/60A61K33/08A61K45/06A61K2300/00
Inventor 邹方霖卢星邹礼常王建霞王艺羲
Owner CHENGDU KUACHANG SCI & TECH CO LTD
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