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Preparation method of choline bitartrate

A technology of choline bitartrate and choline, which is applied in the field of preparation technology of choline bitartrate, can solve the problems of high solubility of choline bitartrate, short service life of resin, and low product quality, and achieve high product quality and high product quality. Good, low cost effect

Inactive Publication Date: 2018-10-26
天津辰力工程设计有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This route has better product quality, but has two obvious disadvantages: one is that the ion exchange resin has a volume change of 60-120% before and after adsorption of quaternary ammonium ions, so the service life of the resin is shorter, which increases the cost of the product
Second, because choline bitartrate has a great solubility in water, in order to obtain solid pure product, the post-treatment process and equipment requirements are relatively high.
This process has a simple reaction and is easy to industrialize, but the product quality is not high

Method used

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  • Preparation method of choline bitartrate
  • Preparation method of choline bitartrate
  • Preparation method of choline bitartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1500kg of aqueous ethylene oxide solution and 1000kg of methanol solution with a mass concentration of 40% are added into the choline reactor 4 replaced by nitrogen gas by gravity respectively, and 810kg of pure trimethylamine is added into the choline reactor 4 by pump 6, and the reaction pressure Be 0.2MPaG, react after 1 hour, send in the choline bitartrate reactor 5 with pump 6 choline solution 3310kg (choline content 1650kg). 2045kg of tartaric acid solids are added into the choline hydrogen tartrate reactor 5 with a sealed hopper again, the reaction pressure is 1kPaG, and the reaction temperature is 20°C. After reacting for 3 hours, feed low-pressure steam 10 into the jacket, and evaporate after 2 hours , then feed circulating water to cool down, and after being cooled to 45°C, the material is put into the centrifuge 12, and the solid material is sent to the drum dryer 13 for drying after the centrifugation, so as to obtain 3450kg of finished product choline bitart...

Embodiment 2

[0041] Respectively mass concentration is 50% ethylene oxide aqueous solution 1200kg, methanol solution 1000kg is added in the choline reactor 4 that has been replaced by nitrogen gas, pure trimethylamine 810kg joins in the choline reactor 4 by pump 6, reaction pressure Be 0.6MPaG, react after 1 hour, send in the choline bitartrate reactor 5 with pump 6 choline solution 3010kg (choline content 1650kg). Then 2045kg of tartaric acid solids are added to the choline bitartrate reactor 5 with a sealed hopper, the reaction pressure is 5kPaG, and the reaction temperature is 70°C. After reacting for 3 hours, feed the low-pressure steam 10 into the jacket, evaporate after 1.5 hours , then feed circulating water to cool down, and after being cooled to 45°C, the material is put into the centrifuge 12, and the solid material is sent to the drum dryer 13 for drying after the centrifugation, so as to obtain 3450kg of finished product choline bitartrate.

Embodiment 3

[0043] Respectively mass concentration is 60% ethylene oxide aqueous solution 1000kg, methanol solution 1000kg add in the choline reaction kettle 4 that has been replaced by nitrogen gas, pure trimethylamine 810kg joins in the choline reaction kettle 4 by pump, and reaction pressure is 0.4MPaG, after reacting 1 hour, choline solution 3010kg (choline content 1650kg) is sent in the choline bitartrate reactor 5 with pump 6. 2045kg of tartaric acid solids are added to the choline hydrogen tartrate reactor 5 with a sealed hopper, the reaction pressure is 3kPaG, and the reaction temperature is 50°C. After reacting for 3 hours, feed the low-pressure steam 10 into the jacket, evaporate after 1 hour , then feed circulating water to cool down, and after being cooled to 45°C, the material is put into the centrifuge 12, and the solid material is sent to the drum dryer 13 for drying after the centrifugation, so as to obtain 3450kg of finished product choline bitartrate.

[0044] In the abo...

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Abstract

The invention provides a preparation method of choline bitartrate. The preparation method comprises the following steps: enabling an ethylene oxide water solution, trimethylamine and methanol to flowinto a choline reaction kettle; reacting at room temperature to produce a choline solution; conveying the generated choline solution into a choline bitartrate reaction kettle through a pump adding a certain amount of tartaric acid from a solid feeding opening; reacting under the protection of nitrogen sealing to produce a choline bitartrate solution; after reaction is finished, introducing low-pressure steam into a jacket and evaporating the methanol in the reaction kettle; after condensing methanol steam, recycling; then introducing circulating water into the jacket of the reaction kettle after the methanol is evaporated, and cooling; separating the choline bitartrate out from the reaction kettle; then carrying out solid-liquid separation and drying through a centrifuging machine and a drying device to obtain finished-product choline bitartrate. According to the preparation method provided by the invention, ion exchange resin is not used in a technical route, so that the cost is low and the quality of a product is high; the technical route of a technology is simple and the defects of an existing process technology are overcome.

Description

technical field [0001] The invention belongs to the field of fine chemicals, in particular to a preparation technology of choline bitartrate. Background technique [0002] Choline bitartrate is a white, hygroscopic crystalline powder with sour taste, odorless or unpleasant trimethylamine odor; easily soluble in water, slightly soluble in ethanol, insoluble in chloroform, ether and benzene. The structural formula is as follows: [0003] [0004] Choline bitartrate is a salt of choline, and like dihydrocholine citrate, it is a nutritional supplement and fat-removing agent. It can promote the metabolism of fat and prevent the accumulation of fat in the liver. As a vitamin product, it is widely used in medicines, health care products and food nutrition additions. Pure product is colorless or white crystalline particles, easy to absorb moisture. [0005] At present, the preparation technology of choline bitartrate comprises: [0006] 1. Prepared by ion exchange resin. An...

Claims

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Application Information

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IPC IPC(8): C07C213/08C07C215/40C07C51/41C07C59/255
CPCC07C51/412C07C213/00C07C213/08C07C215/40C07C59/255
Inventor 马升勇白洪涛胡明华白志芳赵文文王宇方佳尹横博高晶晶王立成胡昌林耿钰淞曹文江
Owner 天津辰力工程设计有限公司
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