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Preparation method and application of bezoar detoxification buccal patch
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A technology of Niuhuangjiedu tablet and oral patch applied in the field of oral patch
Inactive Publication Date: 2018-11-02
广州市上为医药科技有限公司
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Abstract
Description
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From the perspective of oral administration, oral preparations have some disadvantages
Method used
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Embodiment 1
[0006] Step 1. Weigh the medicinal materials according to the ratio of 0-0.1g artificial bezoar, 0-1g realgar, 0-4g gypsum, 0-4g rhubarb, 0-3g skullcap, 0-2g bellflower, 0-1g licorice, and 0-0.5g borneol .
[0007] Step 2. Grind the artificial bezoar into fine powder, pass through a 100-mesh sieve, and collect the powder.
[0008] Step 3. The realgar water is prepared into a very fine powder by water flying method, and the powder is collected.
[0010] Step 5. Rhubarb, Scutellaria baicalensis, Platycodon grandiflorum and licorice are extracted by water and alcoholprecipitation, the collected solution is filtered, and concentrated into a medicinal extract.
[0016] Step 1. Take the crushed rhubarb medicinal powder, add 50%-90% ethanol to soak it, reflux extraction, filter, after the filtrate is evaporated to dryness under reduced pressure, add 0.1%-10% hydrochloric acid solution, heat and reflux for 0.5h-5h , extracted with chloroform, and dried under reduced pressure to obtain rhubarb extract.
[0017] Step 2. Grinding the artificial bezoar and gypsum into powder, passing through a 100-mesh sieve, and collecting the powder.
[0018] Step 3. The realgar water is prepared into a very fine powder by water flying method, and the powder is collected.
[0019] Step 4. Add a small amount of ethanol to dissolve the borneol, and adopt a dry grinding method to clathrate with β-cyclodextrin to obtain a β-cyclodextrin inclusion complex of borneol.
[0020] Step 5. Scutellaria baicalensis, Platycodon grandiflora and licorice are extracted by reflux at 100°C, and the extract is concentrated under reduced pressure to 5 times the amount of the ...
Embodiment 3
[0026] Step 1. Inclusion complex of borneol with β-cyclodextrin by adopting ethanol saturated solution method to prepare β-cyclodextrin inclusion compound of borneol.
[0027] Step 2. Extract with water. Chinese medicinal materials such as gypsum, rhubarb, scutellaria baicalensis, bellflower and licorice are extracted at 80°C under reflux. After the extract is concentrated, an appropriate amount of 95% ethanol is added for alcoholprecipitation for 24 hours, filtered, and the filtrate is concentrated and dried.
[0028] Step 3. The realgar is prepared into a very fine powder by the water-flying method, and the powder is collected.
[0029] Step 4. Finely grind the artificial bezoar, pass through a 100-mesh sieve, and collect the powder.
[0031] Step 6. After the above-mentioned powders ar...
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Abstract
The invention relates to a preparation method and application of a bezoar detoxification buccal patch used for treating gingival pain and swelling, mouth and tongue sores and the like. A bezoar detoxification tablet has the effects of clearing away heat and toxic materials, and is used for relieving internal fire-heat, swollen sore throats, gingival pain and swelling, mouth and tongue sores and swelling and pain of eyes. The existing varieties include bezoar detoxification pills, bezoar detoxification tablets, bezoar detoxification soft capsules, bezoar detoxification capsules and the like; all of the preparations are oral preparations. The bezoar detoxification tablets are made into the buccal patch, so that the biological adhesion performance is realized; the buccal patch realizes the unidirectional local medicine release and continuous medicine release, and is convenient in use. After the medication, the acting time in the focus position is prolonged, so that the medicine maintainsthe continuous and effective concentration in the affected parts; the bioavailability is improved; the curative effect is sufficiently achieved; the gingival pain and swelling and mouth and tongue sores can be effectively treated.
Description
technical field [0001] The invention relates to an oral patch for treating oral ulcers, gingival swelling and pain, and aphtha of the mouth. On the basis of the traditional Niuhuangjiedu Tablets, a new preparation technology is used to prepare a convenient-to-use tablet with the effect of clearing away heat and detoxification. Oral patch. The bezoar detoxification oral patch has a strong therapeutic effect on oral diseases such as oral ulcers, gingival swelling and pain, and aphtha of the mouth and tongue. Background technique [0002] The prescription of the present invention is similar to that of Niuhuangjiedu Tablets, and is a technologically upgraded product of Niuhuangjiedu Tablets. After retrieval, there are only oral dosage forms such as Niuhuangjiedu Tablets, Niuhuangjiedu Pills, Niuhuangjiedu Capsules and Niuhuangjiedu Soft Capsules, and other dosage forms have not been reported. From the perspective of oral administration, oral preparations have some disadvantage...
Claims
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Application Information
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