Preparation method of drug slow-release antibacterial dressing and drug slow-release antibacterial dressing prepared by means of preparation method

A slow-release, drug technology, used in medical science, bandages, etc., can solve problems such as organ damage, achieve good re-epithelialization, avoid adverse effects, and prevent adverse effects.

Active Publication Date: 2018-11-02
FUZHOU UNIV
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Problems solved by technology

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  • Preparation method of drug slow-release antibacterial dressing and drug slow-release antibacterial dressing prepared by means of preparation method
  • Preparation method of drug slow-release antibacterial dressing and drug slow-release antibacterial dressing prepared by means of preparation method
  • Preparation method of drug slow-release antibacterial dressing and drug slow-release antibacterial dressing prepared by means of preparation method

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Embodiment

[0030] A preparation method of drug slow-release antibacterial dressing, comprising the following steps:

[0031] (1) Dissolve carboxymethyl chitosan, macromolecular collagen, and aminoglycoside antibiotics in deionized water, and stir evenly to obtain a mixed solution. The mass ratio of carboxymethyl chitosan to macromolecular collagen in the mixed solution is 0.75-2.5: 1; the concentration of aminoglycoside antibiotics is 0.5-1 mmol / L;

[0032] (2) Pour the mixed liquid obtained in step (1) into the mold, let it stand for defoaming, freeze-dry, and obtain an uncrosslinked spongy material after drying;

[0033] (3) Soak the uncrosslinked spongy material obtained in step (2) in an absolute ethanol solution containing EDC / NHS, and the amount of EDC is based on the excess molar amount of EDC relative to the total molar amount of carboxyl groups in the mixed solution. Standard, the molar ratio of EDC to NHS is 4:1, cross-linking reaction at room temperature for 20 h, discard the...

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Abstract

The invention discloses a preparation method of drug slow-release antibacterial dressing and drug slow-release antibacterial dressing prepared by means of the preparation method. The preparation method comprises the steps of (1) mixing carboxymethyl chitosan, macromolecular collagen, and aminoglycoside antibiotics; (2) pouring the mixture into a mold, allowing standing, and drying to obtain non-crosslinked sponge material; (3) soaking the non-crosslinked sponge material in anhydrous ethyl alcohol solution containing EDC/NHS (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-Hydroxysuccinimide),and crosslinking to obtain composite crosslinked sponge dressing that is antibacterial dressing. Amino groups of the antibiotics covalently bond with carboxyl groups of carboxymethyl chitosan and collagen to form amido bonds, and in this manner, the antibiotics are grafted to dressing matrix. Slow breaking of the amido bonds on a polymer framework allow the antibiotics of the dressing to release slowly; therefore, antibacterial dressing products having good biocompatibility, long-term antibacterial activity and wound healing promotion are prepared.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a preparation method of a drug sustained-release antibacterial dressing and a product thereof. Background technique [0002] In order to avoid wound infection, wound dressings should have good antibacterial activity. An ideal antimicrobial dressing would effectively kill bacteria or fungi in wound infections, prevent bacterial biofilm formation, and prevent wound reinfection during healing, wound inspection, surgery, or dressing changes. However, the current commonly used antibacterial dressing preparation method is to physically mix small molecule drugs in the material (for example, the Chinese patent with the authorized announcement number CN201337582 discloses a method of adding ciprofloxacin to chitosan glue by physical mixing. method for preparing chitosan antiseptic dressings), which provides a viable option for the treatment of wound infections. However, because the antibacterial drug...

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0033A61L26/0085A61L26/009A61L26/0095A61L2300/232A61L2300/404A61L2300/604C08L5/08C08L89/00
Inventor 李锋石贤爱胡圣学
Owner FUZHOU UNIV
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