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Up-conversion nanoparticles and graphene quantum dot composite materials and preparation methods for near-infrared photodynamic therapy and fluorescence imaging

A technology of graphene quantum dots and nanoparticles, applied in the field of composite materials

Active Publication Date: 2020-05-01
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, composite materials that can use near-infrared light for photodynamic therapy and near-infrared imaging have not been reported.

Method used

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  • Up-conversion nanoparticles and graphene quantum dot composite materials and preparation methods for near-infrared photodynamic therapy and fluorescence imaging
  • Up-conversion nanoparticles and graphene quantum dot composite materials and preparation methods for near-infrared photodynamic therapy and fluorescence imaging
  • Up-conversion nanoparticles and graphene quantum dot composite materials and preparation methods for near-infrared photodynamic therapy and fluorescence imaging

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Experimental program
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Embodiment

[0056] Step 1. Preparation of upconversion nanoparticles β-NaYF 4 :Yb 3+ ,Er 3+

[0057] 0.8mmol YCl 3 ·6H 2 O, 0.18 mmol YbCl 3 ·6H 2 O, 0.02 mmol ErCl 3 ·6H 2 O, 6mL oleic acid and 15mL oleylamine were stirred and mixed uniformly in a 50mL three-necked flask under the protection of argon. Use a temperature-controlled electric heating mantle to heat to 160°C to form a uniform solution, and keep it for one hour, and you can see the dissolution of the rare earth salt. After the solution was cooled to room temperature, add 10mL of 2.5mmol NaOH and 4mmol NH 4 F in methanol and stirred for 30 min. Subsequently, the temperature was raised to 100°C and vacuum was applied to remove methanol, oxygen and moisture in the solution. Argon was then bubbled through the solution and the temperature was raised to 300°C for 1 hour. After the solution was cooled to room temperature, the obtained nanocrystals were precipitated with absolute ethanol, and washed alternately with cycloh...

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Abstract

The invention relates to the technical field of composites, in particular to an upconverting nanoparticle and graphene quantum dot composite capable of realizing near-infrared photodynamic therapy andfluorescence imaging simultaneously and a preparation method. According to the prepared composite, graphene quantum dots can be bonded together with upconverting nanoparticles, the composite is homogeneously spherical, and particle size is about 35 nm. Absorption spectra of the graphene quantum dots in the composite can overlap well with emission spectra of the upconverting nanoparticles, so thatenergy transfer is realized between the two materials. When the two materials make contact, the upconverting nanoparticles can absorb near-infrared light and emit ultraviolet light and visible lightunder irradiation of 980nm laser, the emitted ultraviolet light and visible light can be absorbed by the graphene quantum dots and subjected to a reaction with ambient oxygen, singlet oxygen with cytotoxicity is generated, and red light is emitted, so that photodynamic therapy and fluorescence imaging under near-infrared excitation are realized.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to an up-conversion nanoparticle and graphene quantum dot composite material and a preparation method that simultaneously realize near-infrared photodynamic therapy and fluorescence imaging. Background technique [0002] Photodynamic therapy has been widely used in the medical field, such as the treatment of senile plaques, infections caused by viruses, and malignant tumors. The principle of photodynamic therapy is that under the excitation of light of a specific wavelength, the photosensitizer molecules absorb the light and are excited from the ground state to the excited state. The molecules in the excited state are unstable and can react with the surrounding oxygen molecules to transfer energy to oxygen. molecule, generating singlet oxygen, and returning itself to the ground state. Therefore, photodynamic therapy is a minimally invasive treatment modality with high s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/85C09K11/02A61K41/00A61K49/00A61P35/00G01N21/64
CPCA61K41/0057A61K49/0054A61P35/00C09K11/02C09K11/7773G01N21/6428
Inventor 张海元孙秀娟常赟程岩冯艳林
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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