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Curcumin liquid crystal with improved medicine bioavailability

一种姜黄素、液晶的技术,应用在姜黄素制备领域,能够解决生物利用度低、口服吸收少、稳定性差等问题,达到增强疗效、增强免疫力、提高稳定性和溶解性的效果

Inactive Publication Date: 2018-11-06
吴彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: Curcumin has a wide range of pharmacological effects, good pharmacological activity and application prospects, but curcumin has defects such as strong hydrophobicity, less oral absorption, poor stability and low bioavailability in vivo, Provided is a method for preparing highly soluble curcumin liquid crystals. The method first extracts curcumin powder from ginger slices, uses triglyceride as a raw material, and supplements acarbose and amino acids to prepare highly soluble curcumin. Liquid crystal, this method utilizes acarbose as uronidase inhibitor, can reduce the biotransformation of curcumin in vivo, obviously improve the bioavailability of curcumin in vivo, strengthen the pharmacological activity of curcumin, not only solve the problem of curcumin The defects of low oral absorption and poor stability, the prepared liquid crystal liposome has solved the problem of poor water solubility of curcumin, greatly improving the bioavailability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Take 2 pieces of ginger and put them into a jet grinder to grind them into minced ginger, put 20g of minced ginger into a 500mL beaker, add 200mL of sodium hydroxide solution with a concentration of 0.02mol / L, transfer it to a water bath, raise the temperature to 50°C, and let it stand for extraction for 3 hours , filtered to obtain the alkaline water extract; take 100mL and add 15mL of acetone to the above alkaline water extract, stir for 1h with a magnetic stirrer at a stirring speed of 300r / min, separate the organic layer after standing for 1h, and move it into a distillation device , heated up to 80°C to distill off acetone, adjusted its pH value to 1 with a hydrochloric acid solution with a concentration of 0.02mol / L, allowed to stand for 2 hours to precipitate curcumin, dried at 60°C to constant weight to obtain curcumin powder; weighed Put 2g of triglycerides into a 200mL vial, add 6g of curcumin powder and 2g of acarbose prepared above, add 20mL of absolute ethan...

example 2

[0020] Take 3 pieces of ginger and put them into a jet grinder to grind them into minced ginger, put 25g of minced ginger into a 500mL beaker, add 250mL of sodium hydroxide solution with a concentration of 0.02mol / L, transfer it to a water bath, raise the temperature to 55°C, and let it stand for extraction for 4h , filtered to obtain the alkaline water extract; take 150mL and add 18mL acetone to the above alkaline water extract, stir for 1h with a magnetic stirrer at a stirring speed of 350r / min, separate and obtain the organic layer after standing for 1h, and move it into a distillation device , heated up to 85°C to distill off acetone, adjusted its pH value to 1 with a hydrochloric acid solution with a concentration of 0.02mol / L, allowed to stand for 2 hours to precipitate curcumin, dried at 65°C to constant weight to obtain curcumin powder; weighed Put 2g of triglycerides into a 200mL vial, then add 8g of curcumin powder and 3g of acarbose prepared above, add 25mL of absolu...

example 3

[0023] Take 3 pieces of ginger and put them into a jet grinder to grind them into minced ginger, put 30g of minced ginger into a 500mL beaker, add 300mL of sodium hydroxide solution with a concentration of 0.02mol / L, transfer it to a water bath, raise the temperature to 60°C, and let it stand for extraction for 6h , filtered to obtain the alkaline water extract; take 200mL and add 30mL acetone to the above alkaline water extract, stir for 2h with a magnetic stirrer at a stirring speed of 400r / min, separate the organic layer after standing for 2h, and move it into a distillation device , heated up to 90°C to distill off acetone, adjusted its pH value to 2 with a hydrochloric acid solution with a concentration of 0.02mol / L, allowed to stand for 3 hours to precipitate curcumin, dried at 70°C to constant weight to obtain curcumin powder; Put 3g of triglycerides into a 200mL vial, then add 10g of curcumin powder and 5g of acarbose prepared above, add 30mL of absolute ethanol dropwis...

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PUM

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Abstract

The invention relates to a curcumin liquid crystal with improved medicine bioavailability and belongs to the field of curcumin preparation. According to a method: firstly, curcumin powder is extractedfrom ginger pieces, and by taking triglyceride as a raw material, together with compounding of acarbose and amino acid, a high-solubility curcumin liquid crystal can be prepared. By adopting the method, the acarbose is adopted as a polygalacturonase inhibitor, then bioconversion of the curcumin in bodies can be reduced, the bioavailability of the curcumin in bodies can be remarkably improved, thepharmacological activity of the curcumin is improved, defects that a curcumin oral liquid is low in absorption and poor in stability can be solved, due to prepared liquid crystal lipidosome, the defect that the curcumin is poor in water solubility is also solved, and the medicine bioavailability can be greatly improved.

Description

technical field [0001] The invention relates to curcumin liquid crystals capable of improving the bioavailability of medicines, and belongs to the field of curcumin preparation. Background technique [0002] Curcumin is a natural active ingredient extracted from turmeric. It is also widely found in other plants of the genus Curcuma. It is currently widely used as a pigment, food additive and seasoning. It has a wide range of sources, is safe and non-toxic. Studies in recent years have shown that curcumin has a wide range of pharmacological effects, such as anti-tumor, improving cardiovascular function, anti-inflammation, anti-virus, liver protection, and enhancing immunity. It has good pharmacological activity and application prospects, but curcumin has hydrophobic However, the disadvantages of strong drug resistance, low oral absorption, poor stability and low bioavailability in vivo have seriously affected its clinical use. Acarbose is an effective glucosidase inhibitor, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/12A61K47/14A61K47/18A61K47/26A61P1/16A61P9/00A61P29/00A61P31/12A61P35/00A61P37/04
CPCA61K9/0002A61K31/12A61K36/9068A61K47/26
Inventor 不公告发明人
Owner 吴彬