A kind of antibacterial modification method of polymer material

A polymer material and modification technology, applied in the fields of plant fibers, organic chemistry, fiber processing, etc., can solve the problems of biological safety, easy leakage of nano-silver, and inability to form chemical bonds between polymers and nano-silver, so as to avoid Effects of Biosafety Issues

Active Publication Date: 2020-09-25
济南鸿湾生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, no matter the antibacterial materials prepared by the physical mixing method or the in situ reduction method, the inevitable defect is that the polymer and the nano-silver cannot form a strong chemical bond, and the two only rely on the intermolecular interaction to construct the material. Nanosilver is easy to leak during the process, causing serious biosafety problems

Method used

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  • A kind of antibacterial modification method of polymer material
  • A kind of antibacterial modification method of polymer material
  • A kind of antibacterial modification method of polymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1. Synthesis of diazomethane

[0062] (1) Synthesis of compound 1

[0063] Weigh 4.42 g of anisole and dissolve in 50 mL of dichloromethane, then add 5.00 g of benzoyl chloride dropwise, and stir at room temperature for 24 hours after the addition is complete. After the reaction, it was washed with 50 mL of saturated brine, and washed three times. The lower organic phase was dried with about 10 g of anhydrous magnesium sulfate, filtered, and rotary steamed to obtain a crude product. The crude product was dissolved in dichloromethane, and then separated by column chromatography with a ratio of n-hexane: ethyl acetate = 4:1 to obtain a pure product (yield 30%).

[0064] (2) Synthesis of compound 2

[0065] Compound 1 (1 g) and 35 mL of absolute ethanol were added to a 100 mL round-bottomed flask. After completely dissolved, 80% hydrazine hydrate (2.19 g) was added, and 2 drops of acetic acid were added dropwise. The reaction time was 48 hours at 85°C. After the reaction is com...

Embodiment 2

[0076] 1. Synthesis of diazomethane

[0077] The same as in Example 1.

[0078] 2. Surface modification of nylon cloth

[0079] Dissolve 0.2g of compound 3 in 5mL of dichloromethane solution, add 2cm×2cm×0.1cm nylon cloth to fully soak the nylon cloth. Then, the methylene chloride was removed by rotary evaporation, so that compound 3 was uniformly adsorbed on the surface of the nylon cloth. Put it into a blast drying box and heat it to 120°C and keep it for 20 minutes. The color of nylon cloth changed from purple to yellow, indicating that the chemical modification was completed. Finally, the nylon cloth was washed 3 times with dichloromethane, 20 mL each time, and dried in a blast drying box after washing.

[0080] 3. Preparation of nano silver solution

[0081] The same as in Example 1.

[0082] 4. Preparation of antibacterial nylon cloth

[0083] The silver nanoparticle solution (5 mL) was dissolved in 15 mL of ethylene glycol solution. Then, the surface-modified nylon cloth was s...

Embodiment 3

[0085] 1. Synthesis of diazomethane

[0086] The same as in Example 1.

[0087] 2. Surface modification of polyurethane

[0088] Dissolve 0.2 g of compound 3 in 5 mL of cyclohexane solution and add it dropwise to the surface of the polyurethane film of 2 cm×2 cm×0.1 cm, and dry it with ear wash balls while dripping, so that compound 3 is uniformly adsorbed on the surface of the polyurethane film. Put it into a blast drying box and heat it to 120°C and keep it for 20 minutes. The color of the polyurethane changes from purple to yellow, indicating that the chemical modification is complete. Finally, the polyurethane was washed 3 times with cyclohexane, 20 mL each time, and dried in a blast drying box after washing.

[0089] 3. Preparation of nano silver solution

[0090] The same as in Example 1.

[0091] 4. Preparation of antibacterial polyurethane film

[0092] The silver nanoparticle solution (5 mL) was dissolved in 15 mL of ethylene glycol solution. Then, the surface-modified polyur...

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Abstract

The invention relates to an antibacterial modification method of polymer materials. The antibacterial modification method comprises following steps: preparing diazomethane with a thioether group; using diazomethane to carry out chemical modification on the surface of a polymer material; and carrying out Ag-S coordination reactions between a nano silver particle solution and the chemically modifiedpolymer material. After antibacterial modification, Ag is bonded with the polymer material through chemical bonds, so during the using process, silver leakage is prevented, and the biological safetyis guaranteed.

Description

Technical field [0001] The invention relates to an antibacterial modification method of polymer materials, belonging to the technical field of antibacterial materials. Background technique [0002] At present, the biggest problem with implanted / interventional medical polymer materials is that bacteria tend to adhere to the surface and form biofilms in clinical applications, which can cause infection, surgery and medical accidents. According to preliminary statistics from the National Institutes of Health, 80% of bacterial diseases are related to medical materials. Bacterial biofilms are ubiquitous in artificial devices in the body, and have strong drug resistance and immune evasion. Even if the normal dose is hundreds of times the drug can not be effectively eliminated, which often endangers the lives of patients. Take the cardiovascular system as an example, the death rate caused by artificial device infection is close to 100%. Therefore, obtaining medical polymer materials wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M11/83D06M13/322D06M13/252C08J7/12C07C319/20C07C323/48D06M101/06D06M101/34C08L75/04
CPCC07C319/20C08J7/12C08J2375/04D06M11/83D06M13/252D06M13/322D06M16/00D06M2101/06D06M2101/34C07C323/48
Inventor 杨鹏飞潘韵霖王永清柳沛丰
Owner 济南鸿湾生物技术有限公司
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