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Tumor diagnosis and treatment integrated nanomaterial and preparation method thereof

A technology for nanomaterials and tumors, applied in nanotechnology, nanomedicine, nano-optics, etc., can solve problems such as low signal-to-noise ratio, radiation damage, and restrict the development of multifunctional nanomaterials, and achieve the effect of low synthesis temperature

Inactive Publication Date: 2018-11-13
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional integrated nanomaterials for diagnosis and treatment based on optical imaging have the disadvantages of unavoidable radiation damage and low signal-to-noise ratio during imaging, which also restricts the development of such multifunctional nanomaterials.

Method used

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  • Tumor diagnosis and treatment integrated nanomaterial and preparation method thereof
  • Tumor diagnosis and treatment integrated nanomaterial and preparation method thereof
  • Tumor diagnosis and treatment integrated nanomaterial and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take an appropriate amount of 0.05mol·L -1 Zn(CH 3 COO) 2 and 0.02mol·L -1 Cr(CH 3 COO) 3 solution and 10mL of the above-mentioned configuration of Na 6 Ga 4 GeO 11 The solutions were mixed and ion-exchanged at room temperature for 3 h with a stirring speed of 500 rpm. After stirring, transfer it to a reaction kettle, conduct a hydrothermal reaction at 200°C for 10h, centrifuge at 9000rpm, wash alternately with water and ethanol for 3 times, and place the precipitate in a vacuum drying oven at 50°C for 10h to obtain a powder sample. In order to improve the long-lasting luminescence properties of the obtained samples, they were placed in a muffle furnace and calcined at 850°C for 6 hours, and nano long-lasting luminescent materials with strong afterglow could also be obtained.

[0024] Utilize X-ray diffraction to analyze the material obtained in embodiment 1, obtain its X-ray diffraction pattern, as figure 1 shown. with ZnGa 2 o 4 It is consistent with the ...

Embodiment 2

[0027] Take 5mL concentration as 0.01g·mL -1 After mixing the aqueous solution of dimethylimidazole with 350μL 0.1M HCl aqueous solution, add 5mL 0.004g·mL -1 Zn(NO 3 ) 2 Aqueous solution, react at room temperature for 15min, stirring speed is 500rpm. After stirring, centrifuge at 11000 rpm, wash the precipitate with water and ethanol three times alternately, and dry it in vacuum at 40° C. for 6 h to obtain ZIF-8 nanomaterials.

[0028] Such as figure 1 As shown, the material obtained in Example 2 was analyzed by X-ray diffraction, and it was confirmed that the diffraction pattern of this sample was consistent with the standard pattern of ZIF-8, and no obvious miscellaneous peaks were observed.

[0029] The aqueous solution of nanoparticles obtained in Example 2 was analyzed with a UV-visible spectrophotometer, and it was found that the material had no obvious absorption in the range of 600-800 nm.

Embodiment 3

[0031] Take an appropriate amount of 0.05mol·L -1 Zn(CH 3 COO) 2and 0.02mol·L -1 Cr(CH 3 COO) 3 solution and 10mL of the above-mentioned configuration of Na 6 Ga 4 GeO 11 The solutions were mixed and ion-exchanged at room temperature for 3 h with a stirring speed of 500 rpm. After stirring, transfer it to a reaction kettle, conduct a hydrothermal reaction at 200°C for 10h, centrifuge at 9000rpm, wash alternately with water and ethanol for 3 times, and place the precipitate in a vacuum drying oven at 50°C for 10h to obtain a powder sample. In order to improve the long-lasting luminescent performance of the obtained sample, it was placed in a muffle furnace and calcined at 850° C. for 6 hours to obtain a nano long-lasting luminescent material with strong afterglow. Take 15mg of the above sample and 5mL concentration is 0.01g·mL -1 After mixing the aqueous solution of dimethylimidazole with 350μL 0.1M HCl aqueous solution, add 5mL 0.004g·mL -1 Zn(NO 3 ) 2 Aqueous sol...

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Abstract

The invention provides a tumor diagnosis and treatment integrated nanomaterial and a preparation method thereof, and relates to a long afterglow-based nanomaterial. The tumor diagnosis and treatment integrated nanomaterial has a core-shell material structure. The method comprises the steps of obtaining long afterglow nanoparticles by combining ion exchange with a hydrothermal method, and then calcining; mixing the calcined long afterglow nanoparticles with a dimethylimidazole solution, ultrasonically dispersing, and then adding a Zn source; carrying out a reaction in a mixing system, washing after the reaction is finished, and carrying out centrifugal separation to obtain white powder; drying to obtain the tumor diagnosis and treatment integrated nanomaterial. The preparation method can beused for obtaining the tumor diagnosis and treatment integrated composite material which combines a high-efficiency long afterglow luminous nanomaterial with a metal-organic framework having properties of high-efficiency drug loading and external stimulus release response; furthermore, the tumor diagnosis and treatment integrated nanomaterial also has a low synthesis temperature characteristic, thus providing favorable conditions for large-scale production.

Description

technical field [0001] The present invention relates to nanomaterials based on long afterglow, in particular to an integrated nanomaterial for tumor diagnosis and treatment and a preparation method thereof. Background technique [0002] Since French scientists applied red light long afterglow materials to the field of biological imaging, long afterglow imaging has attracted extensive attention from researchers due to its low radiation damage and high imaging signal-to-noise ratio. However, a single long-persistence optical imaging is obviously not enough to deal with the threat of cancer to human health. Therefore, many multimodal imaging probes based on long-persistence optical imaging have also attracted the attention of researchers because they can provide more tumor diagnostic information. For example, researchers ([1] Maldiney, T.; Doan, B.-T.; Alloyeau, D.; Bessodes, M.; Scherman, D.; Richard, C., Adv. Funct. Mater. 2015, 25, (2),331-338) in ZnGa 2 o 4 :Cr 3+ Gd i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61P35/00B82Y5/00B82Y20/00
CPCA61K49/0017A61K49/0093A61P35/00B82Y5/00B82Y20/00
Inventor 解荣军吕营庄逸熙周天亮李烨
Owner XIAMEN UNIV