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Preparation method of a covalent-microcrystalline-ionic triple interpenetrating network hydrogel

An interpenetrating network and semi-interpenetrating network technology, which is applied in the field of preparation of covalent-crystallite-ion triple interpenetrating network hydrogel, can solve the problems of poor mechanical properties of hydrogels, and can solve the problem of poor mechanical properties. good effect

Active Publication Date: 2020-04-07
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above-mentioned deficiencies existing in the prior art, the object of the present invention is to provide a preparation method of covalent-microcrystalline-ionic triple interpenetrating network hydrogel, to solve the problem of poor mechanical properties of the existing hydrogel

Method used

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  • Preparation method of a covalent-microcrystalline-ionic triple interpenetrating network hydrogel
  • Preparation method of a covalent-microcrystalline-ionic triple interpenetrating network hydrogel
  • Preparation method of a covalent-microcrystalline-ionic triple interpenetrating network hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0041] 1) Add 10g of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) into 10ml of deionized water, stir evenly, heat up to 50°C, take 0.05g of ammonium persulfate and 0.025g of sodium bisulfite and dissolve in 1ml An initiator solution was prepared in water, and the above-mentioned initiator solution was added to the AMPS aqueous solution, and reacted for 20 hours. Most of the water was evaporated, and dried in a vacuum oven to constant weight to obtain PAMPS solid, which was ground into powder and set aside.

[0042] 2) Add 0.5g of polyvinyl alcohol (PVA) to 24ml of deionized water, heat to 95°C to dissolve, take 0.2g of PAMPS powder prepared in step 1) and add to the above solution, then add 5.33g of acrylamide (AM) , 0.9g of acrylic acid (AA), 12mg of N,N'-methylenebisacrylamide (MBAA), stirred well to dissolve the solid matter, then dissolved 5mg of potassium persulfate in 1ml of deionized water and added to the previously prepared solution , stirred evenly to obtain a t...

Embodiment 2

[0048] 1) Add 10g of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) into 10ml of deionized water, stir evenly, heat up to 50°C, take 0.05g of ammonium persulfate and 0.025g of sodium bisulfite and dissolve in 1ml An initiator solution was prepared in water, and the above-mentioned initiator solution was added to the AMPS aqueous solution, and reacted for 20 hours. Most of the water was evaporated, and dried in a vacuum oven to constant weight to obtain PAMPS solid, which was ground into powder and set aside.

[0049] 2) Add 0.5g of polyvinyl alcohol (PVA) to 24ml of deionized water, heat to 95°C to dissolve, take 0.2g of PAMPS powder prepared in step 1) and add to the above solution, then add 5.33g of acrylamide (AM) , 0.9g of acrylic acid (AA), 12mg of N,N'-methylenebisacrylamide (MBAA), stirred well to dissolve the solid matter, then dissolved 5mg of potassium persulfate in 1ml of deionized water and added to the previously prepared solution , stirred evenly to obtain a t...

Embodiment 3

[0055] 1) Add 10g of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) into 10ml of deionized water, stir evenly, heat up to 50°C, take 0.05g of ammonium persulfate and 0.025g of sodium bisulfite and dissolve in 1ml An initiator solution was prepared in water, and the above-mentioned initiator solution was added to the AMPS aqueous solution, and reacted for 20 hours. Most of the water was evaporated, and dried in a vacuum oven to constant weight to obtain PAMPS solid, which was ground into powder and set aside.

[0056] 2) Add 0.5g of polyvinyl alcohol (PVA) to 24ml of deionized water, heat to 95°C to dissolve, take 0.2g of PAMPS powder prepared in step 1) and add to the above solution, then add 5.33g of acrylamide (AM) , 0.9g of acrylic acid (AA), 12mg of N,N'-methylenebisacrylamide (MBAA), stirred well to dissolve the solid matter, then dissolved 5mg of potassium persulfate in 1ml of deionized water and added to the previously prepared solution , stirred evenly to obtain a t...

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Abstract

The invention discloses a preparation method of covalent-microcrystalline-ion three-fold interpenetrating network hydrogel. The preparation method comprises the following steps: forming a covalent cross-linked network by a P(AM-AA) chain under the action of a crosslinking agent; then carrying out freezing-room temperature circulating operation on obtained hydrogel and forming covalent-microcrystalline dual-network hydrogel by a PVA (Polyvinyl Acetate) chain through microcrystalline crosslinking; then sequentially immersing into a ferric iron ion solution and de-ionized water; forming the covalent-microcrystalline-ion three-fold interpenetrating network hydrogel through cation-anion combination. The hydrogel prepared by preparation method has good mechanical properties. A preparation process is simple and convenient and the cost is relatively low, so that industrialization is facilitated and the hydrogel has a good application prospect in the field of biomedical engineering.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a preparation method of a covalent-microcrystal-ion triple interpenetrating network hydrogel. Background technique [0002] Hydrogel is a polymer material with a network molecular structure. It has a high water content, and water molecules can freely diffuse and move between polymer networks. This feature makes hydrogels very flexible on the one hand. On the other hand, the hydrogel can also be equipped with special functions, so that the hydrogel has special application value in medical fields such as drug release, prevention of dryness and infection of wounds, and prevention of loss of body fluids. [0003] However, in the field of biomedicine, hydrogels can also be applied to tissue engineering scaffold materials, which has higher requirements for the performance of hydrogels, not only requiring hydrogels to be hydrophilic and biocompatible, T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L33/14C08L29/04C08F291/08C08F220/56C08F220/06C08F222/38C08F120/58C08J3/24
CPCC08F120/58C08F261/04C08F265/04C08J3/243C08J2333/14C08J2429/04C08F220/56C08F220/06C08F222/385
Inventor 高晨邹智挥张雪梅白兰涵李先玉曹桐李斌周怡刘宇霆
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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