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Multi-functional polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle and preparation method thereof

A mesoporous titanium dioxide and nanoparticle technology, applied in the field of medical medicine, can solve the problems of poor dispersibility, insufficient surface functional groups, application limitations, etc., and achieve the effects of low toxicity, simple and convenient preparation method, and less time-consuming.

Active Publication Date: 2018-11-16
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor dispersion of titanium dioxide in water and insufficient surface functional groups, its application in the biomedical field is limited.

Method used

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  • Multi-functional polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle and preparation method thereof
  • Multi-functional polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle and preparation method thereof
  • Multi-functional polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024] 1. Preparation of mesoporous titania nanoparticles

[0025] 1 mL of tetrabutyl titanate (TBT) was added to 15 mL of acetic acid under magnetic stirring, followed by the rapid addition of 0.5 mL of deionized water. The above solution was stirred at room temperature for 10 minutes, then transferred to a hydrothermal reactor and reacted at 150 °C for 12 hours. Finally, white mesoporous titania nanoparticles were obtained by centrifugal washing.

[0026] 2. Preparation of polypyrrole-coated mesoporous titania nanoparticles

[0027] 0.3 g of polyvinyl alcohol (PVA) was added to 4 mL of deionized water and stirred at 60° C. for 20 minutes to completely dissolve it. Disperse 15 mg of mesoporous titania nanoparticles in PVA solution, then add 4 mL of FeCl 3 ·6H 2 O. After 1 hour, 28 μL of pyrrole monomer was added and reacted at 5°C for 4 hours under light-shielded conditions. Finally, the polypyrrole-coated mesoporous titanium dioxide nanoparticles are obtained by centri...

Embodiment 2

[0032] 1. In vitro drug release experiment of polypyrrole-coated drug-loaded mesoporous titania nanoparticles

[0033] Honokiol raw material drug and polypyrrole-coated drug-loaded mesoporous titanium dioxide nanoparticles were simultaneously investigated for in vitro drug release. The results are as follows: Figure 4 shown. At 72 hours, the cumulative drug release rate of honokiol bulk drug only reached 49.7%. In contrast, the cumulative drug release rate of polypyrrole-coated drug-loaded mesoporous titanium dioxide nanoparticles was 70.4% at 12 hours and 93.0% after 72 hours, much higher than the cumulative drug release rate of honokiol bulk drug. Polypyrrole-coated drug-loaded mesoporous titania nanoparticles not only showed a faster release rate, but also had a higher cumulative drug release rate.

[0034] 2. Study on photothermal conversion ability of polypyrrole-coated mesoporous titania nanoparticles

[0035] A series of polypyrrole-coated mesoporous titania nanopar...

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Abstract

The invention discloses a multi-functional polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle and a preparation method thereof. Mesoporous titanium dioxide is used as a drug carrier and a sonosensitizer, combined with a good photothermal conversion material of polypyrrole, and capable of realizing the united anti-tumor effect of chemotherapy, photothermal therapy and sonodynamic therapy. A preparation technology for the polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle is convenient and simple. A particle size is about 156 nm. Passive targeting canbe realized through the high permeability and retention effect of a tumor site, the effective killing effect to tumor cells is realized, and the toxic and side effects to surrounding normal tissues and cells are reduced. In addition, the polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle also has a certain ultrasonic developing potency, and is capable of further realizing precision therapy on the tumor site. The polypyrrole coated drug-loading mesoporous titanium dioxide nanoparticle is good in biocompatibility, capable of reducing pain of a patient during a therapy period, and improving compliance of the patient, and has extensive application prospect.

Description

technical field [0001] The invention relates to the field of medical medicine, in particular to a preparation method and application of polypyrrole-coated drug-loaded mesoporous titanium dioxide nanoparticles. Background technique [0002] Sonodynamic therapy (SDT), as one of the non-invasive therapies for tumors, has received extensive attention in recent years. Sonodynamic therapy uses ultrasound and chemicals that can be stimulated by the ultrasound to kill tumor cells. The mechanism of SDT mainly includes the cavitation effect, the generation of reactive oxygen species that can kill cells and the apoptosis induced by ultrasound. SDT is formed on the basis of photodynamic therapy (PDT), but SDT has deeper tumor penetration than PDT. Because ultrasound can activate the sonosensitizer at the tumor site and play an anti-tumor effect, it has less cytotoxicity to nearby normal cells while killing tumor cells. In addition, SDT can not only increase the permeability of the ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/22A61P35/00A61P29/00A61K31/05
CPCA61K31/05A61K41/0033A61K41/0052A61K49/222A61P29/00A61P35/00A61K2300/00
Inventor 张良珂何跃
Owner CHONGQING MEDICAL UNIVERSITY
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