A kind of pesticide sustained-release microsphere and preparation method thereof

A technology for slow-release microspheres and pesticides, applied in the field of pesticides, can solve the problems of fast drug release rate and low drug entrapment rate, and achieve the effects of improving slow-release performance, expanding control spectrum and reducing pores

Active Publication Date: 2021-02-26
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the fast degradation rate of PBS under environmental conditions such as soil and fresh water, and the formation of micropores on the surface of the microspheres after encapsulation, the drug entrapment rate is low and the drug release rate is too fast

Method used

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  • A kind of pesticide sustained-release microsphere and preparation method thereof
  • A kind of pesticide sustained-release microsphere and preparation method thereof
  • A kind of pesticide sustained-release microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Preparation of drug-containing and carrier oil phase: 0.4g azoxystrobin, 0.25g difenoconazole pesticide technical, 1.365g polybutylene succinate, 0.585g polylactic acid were dissolved in 30ml dichloride In methane, obtain the mixed liquid oil phase containing medicine and carrier; (the weight-average molecular weight of polylactic acid is 140,000, and the weight-average molecular weight of polybutylene succinate is 150,000)

[0027] (2) Preparation of the aqueous phase of the emulsified dispersant: preparing an aqueous polyvinyl alcohol solution with a mass fraction of 25 mg / ml as the aqueous phase;

[0028] (3) Add 30ml of the mixed liquid oil phase in step (1) to the 90ml water phase in step (2), and cut at 6000rpm for 3min at room temperature to obtain an oil-in-water emulsion; The oil-in-emulsion was stirred at a speed of 600 rpm until the dichloromethane solvent was completely volatilized, centrifuged three times at a speed of 10,000 rpm for 7 minutes each time,...

Embodiment 2

[0041] (1) Preparation of drug-containing and carrier oil phase: 0.4 g of azoxystrobin, 0.25 g of difenoconazole pesticide technical, 1.755 g of polybutylene succinate, and 0.195 g of polylactic acid were dissolved in 30 ml of difenoconazole In methyl chloride, the mixed liquid oil phase containing medicine and carrier is obtained; (the weight-average molecular weight of polylactic acid is 100,000, and the weight-average molecular weight of polybutylene succinate is 200,000)

[0042] (2) Preparation of the aqueous phase of the emulsified dispersant: preparing an aqueous polyvinyl alcohol solution with a mass fraction of 15 mg / ml as the aqueous phase;

[0043] (3) Add 30ml of the mixed liquid oil phase in step (1) to the 60ml water phase in step (2), and cut it at 7000rpm for 4min at room temperature to obtain an oil-in-water emulsion at a reaction temperature of 35°C. The oil-in-emulsion was stirred at 800 rpm until the organic solvent evaporated completely, centrifuged three ...

Embodiment 3

[0046] (1) Preparation of drug-containing and carrier oil phase: 0.4 g of azoxystrobin, 0.25 g of difenoconazole pesticide technical, 0.975 g of polybutylene succinate, and 0.975 g of polylactic acid were dissolved in 30 ml of difenoconazole In methyl chloride, the mixed liquid oil phase containing medicine and carrier is obtained; (the weight-average molecular weight of polylactic acid is 200,000, and the weight-average molecular weight of polybutylene succinate is 150,000)

[0047] (2) Preparation of the aqueous phase of the emulsified dispersant: preparing an aqueous polyvinyl alcohol solution with a mass fraction of 22 mg / ml as the aqueous phase;

[0048] (3) Add 30ml of the mixed liquid oil phase in step (1) to 150ml of the water phase in step (2), and cut at 8000rpm for 5min at room temperature to obtain an emulsion; at 35°C, stir the emulsion at a speed of 400rpm , until the organic solvent is completely evaporated, centrifuged at 6000rpm three times for 10min each time...

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Abstract

The object of the invention is to disclose a kind of pesticide slow-release microsphere and preparation method thereof, this pesticide slow-release microsphere of the present invention is made of core material and wall material, and wherein the mass ratio of core material and wall material is 1:(1~ 6), it is characterized in that, described wall material is made up of mass percent as 1: (1~9) polylactic acid (PLA) and polybutylene succinate (PBS); Described core material is made up of two kinds Composition of pesticide raw materials. The present invention utilizes the characteristics of fast solidification rate of PLA in the emulsification process, and mixes it with PBS as a wall material, which can increase the sedimentation rate in the emulsification shearing process, thereby effectively improving the encapsulation rate of the drug; and the two materials of PLA and PBS After mixing, it can effectively reduce the pores on the surface of the microspheres and prolong the release time of the drug. The pesticide slow-release microspheres of the present invention have uniform particle size and regular spherical shape, and the encapsulation rate of the pesticide original drug has reached more than 70%, and the drug release time can reach more than 25 days, and after the drug is released, the wall material is biodegradable , without pollution.

Description

technical field [0001] The invention belongs to the technical field of pesticides, in particular to a pesticide slow-release microsphere and a preparation method thereof. Background technique [0002] Pesticides can effectively control diseases, insect pests and weeds. According to statistics, if pesticides are not used, pest damage will cause 30% to 40% of grain loss, and for some special crops, the loss can reach 100%. In the report of "Leng Yang. Dynamics and Development Trends of Pesticide Preparations in my country [J]. World Pesticides, 2010, 32(a01): 19-21", due to the influence of pesticide application methods and climatic conditions, the effective use of conventional pesticide preparations The rate is only 10-30%, and up to 90% of the applied pesticides do not reach the predetermined target with accurate dosage within a certain effective time. In the development of pesticide formulation processing technology, pesticide slow and controlled release technology is a pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/26A01N43/54A01N37/50A01N47/24A01N43/653
CPCA01N25/26A01N37/50A01N43/54A01N43/653A01N47/24
Inventor 王娅李晓刚王昱翔朱宏建张星陈伟
Owner HUNAN AGRICULTURAL UNIV
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