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A kind of preparation method of copper complex and its application

A technology of copper complexes and drugs, which is applied in the field of preparation of copper complexes, can solve the problems of slow degradation process of biological and photodegradation methods, secondary pollution, low adsorption rate of activated carbon, etc., and achieve good recycling ability and good structural stability , The effect of the simple preparation method

Active Publication Date: 2020-08-25
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment methods of drug pollution mainly include activated sludge adsorption, biodegradation, photodegradation, advanced oxidation technology, etc., but due to their respective shortcomings, their practical application is limited.
For example, the adsorption of activated sludge only absorbs and transfers the drug pollutants in the water body to the soil, but does not fundamentally remove the drugs from the environment; the degradation process of biological and photodegradation methods is very slow, which is not enough to eliminate the increasing discharge to the soil. Drugs in the water environment; although advanced oxidation technology has high efficiency in removing pollutants, its cost is high and some toxic by-products will be produced, causing secondary pollution
In contrast, the adsorption method is easy to operate, low in economic cost, and high in efficiency. It has been proven that it can adsorb and remove a variety of drugs. At present, a variety of materials can be used as adsorbents, such as activated carbon, clay, molecular sieves, carbon nanotubes, and metal oxides. However, the adsorption rate of activated carbon is low and it is difficult to recycle; the production cost of carbon nanotubes is high and it is difficult to apply on a large scale; the specific surface area of ​​metal oxides is small and the adsorption effect is not good

Method used

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  • A kind of preparation method of copper complex and its application
  • A kind of preparation method of copper complex and its application
  • A kind of preparation method of copper complex and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of copper complex, comprising the following steps:

[0034] 1) Mix 0.6g of copper chloride dihydrate and 0.2g of 1,4-bis(triazol-1-yl)terephthalic acid, add to 67mL N,N-dimethylformamide and stir well to obtain mixed solution A ; Then add 2.85mL nitric acid and stir for 8min to obtain mixed solution B;

[0035] 2) Take 4 mL of the mixed solution B obtained in step 1) and dispense it into a 15 mL vial, and place the vial at a temperature of 110°C for 14 hours to obtain crystal C;

[0036] 3) Wash the crystal C obtained from step 2) three times with ethanol, then soak the cleaned crystal C in methanol for 2 days, and replace the methanol every 24 hours during this period, and then place the crystal C in dichloromethane Soak for 1 day, and finally place the soaked crystal C in an oven at a temperature of 90° C. to dry for 12 hours to obtain a copper complex.

Embodiment 2

[0038] A preparation method of copper complex, comprising the following steps:

[0039] 1) Mix 1g of copper chloride dihydrate and 0.2g of 1,4-bis(triazol-1-yl)terephthalic acid, then add to 114mL N,N-dimethylformamide and stir well to obtain mixed solution A; Then add 3.85mL nitric acid and stir for 3min to obtain mixed solution B;

[0040] 2) Take 4 mL of the mixed solution B obtained in step 1) and dispense it into a 15 mL vial, and place the vial at a temperature of 130°C for 10 h to obtain crystal C;

[0041] 3) Wash the crystal C obtained from step 2) three times with ethanol, then soak the cleaned crystal C in methanol for 2 days, and replace the methanol every 24 hours during this period, and then place the crystal C in dichloromethane Soak for 1 day, and finally place the soaked crystal C in an oven at a temperature of 110° C. to dry for 8 hours to obtain a copper complex.

Embodiment 3

[0043] A preparation method of copper complex, comprising the following steps:

[0044] 1) Mix 0.7g of copper chloride dihydrate and 0.2g of 1,4-bis(triazol-1-yl)terephthalic acid, then add it into 80mL N,N-dimethylformamide and stir well to obtain a mixed solution A ; Then add 3mL nitric acid and stir for 5min to obtain mixed solution B;

[0045] 2) Take 4 mL of the mixed solution B obtained in step 1) and put it into a 15 mL vial, and place the vial at a temperature of 120°C for 12 hours to obtain crystal C;

[0046]3) Wash the crystal C obtained from step 2) three times with ethanol, then soak the cleaned crystal C in methanol for 2 days, and replace the methanol every 24 hours during this period, and then place the crystal C in dichloromethane Soak for 1 day, and finally place the soaked crystal C in an oven at a temperature of 100° C. to dry for 10 hours to obtain a copper complex.

[0047] In conclusion, the preparation method of copper metal organic framework compound...

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Abstract

The invention discloses a preparation method of a copper complex and application thereof. The preparation method comprises the following steps: 1) mixing copper chloride dehydrate with 1,4-di-(triazole-1-yl) terephthalic acid, and adding the mixture into a solvent to be uniformly stirred to obtain a mixed solution A; and then adding nitric acid to stir the solution to obtain a mixed solution B; 2)in a sealing condition, putting the mixed solution B at 110-130 DEG C to react for 10-14 h to obtain crystals C; and 3) cleaning the crystals C with ethanol for three times, then putting the crystalsC in methanol to be soaked for 2 days, then putting the crystals C in dichloromethane to be soaked for 1 day, and finally putting the crystals C in an oven to be dried to obtain the copper complex. The method disclosed by the invention is simple in synthesis and high in yield. The copper complex has high adsorption efficiency on diclofenac sodium and still has good desorption ability and cyclic utilization ability after adsorbing drug pollutants, so that the copper complex has a potential application in adsorbing drug pollutants in a water environment.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical pollutant adsorbents, in particular to a preparation method and application of a copper complex. Background technique [0002] With the development of the economy and the improvement of living standards, the use of pharmaceuticals and personal care products is increasing. At the same time, pharmaceutical pollutants, as a major category of pharmaceuticals and personal care products, are also a new type of pollution that has attracted widespread attention in recent years. Pollutants are detected in more and more water bodies. Such pollutants mainly include antibiotics, anti-inflammatory drugs, antiepileptic drugs, and blood lipid-lowering drugs. Due to their complex structures and diverse components, they degrade slowly under natural conditions. At the same time, as people continue to produce, use, and discharge, the concentration of pharmaceutical pollutants continues to rise, and drugs can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08B01J20/22B01J20/28B01J20/30C02F1/28C02F101/34C02F101/36C02F101/38
CPCB01J20/223B01J20/28054B01J20/2808C02F1/285C02F2101/34C02F2101/36C02F2101/38C07F1/005
Inventor 李宝红刘建强刘伟聪马爱青罗志董解玉玲郑明彬彭新生施踏青
Owner GUANGDONG MEDICAL UNIV
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