Peripheral nerve stent based on 3D (three-dimensional) printing and preparation method thereof

Abstract

The invention discloses a peripheral nerve stent based on 3D (three-dimensional) printing. The peripheral nerve stent comprises an outer cannula and a filler, wherein the filler is arranged in the outer cannula; the filler is a three-dimensional stent which is curved by a gauze net; the gauze net is made of biological ink. The invention also discloses a preparation method of the peripheral nerve stent. The peripheral nerve stent prepared by the preparation method has the advantages that the bionic elements of structure and composition of natural peripheral nerve are realized; on the basis of ensuring the biocompatibility, the outer cannula of electrospinning material can provide the full structure stability of the stent, the requirement on the ink forming strength can be reduced by the filler in the manufacturing process, the material selection range of the filler is expanded, and the ink can select more biological functions; by injecting or soaking special functional components into the stent, the corresponding biology characteristics are provided for the filler, such as acceleration of axone growth, and acceleration of vascularization.

Description

technical field [0001] The invention relates to the technical field of tissue engineering and bionic structures, in particular to a 3D printing-based peripheral nerve support and a preparation method thereof. Background technique [0002] The anatomical structure of the peripheral nerve is complex, which is divided into epineurium area, nerve fascicular area and interfascicular area, etc. There are also functional structures such as microvessels and connective tissue distributed in each area. In addition, the composition and spatial distribution of different regions are also very complex. Nerve repair materials (or catheters) currently reported in the literature are mainly prepared from a single homogeneous material (such as synthetic materials, natural materials, and acellular matrix materials). According to the principle of nerve regeneration, the structure and composition of the catheter have also been bionically designed (such as Gradient distribution of nerve growth fa...

AI Technical Summary

Problems solved by technology

Although the thermoplastic degradable polyether ester material has a mature printing process and is stable after printing, its mechanical properties are quite different from those of peripheral nerves, and it is difficult to load cells or active proteins under high temperature printing conditions

However, bio-ink materials suitable for cell growth are generally low in strength and poor in stability, and it is difficult to meet the needs of direct printing and stability in later use.

At present, there is no relatively complete process for 3D printing peripheral nerve scaffolds using hydrogel ink materials with good biocompatibility.

Images