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A kind of extremely small iron oxide nanoparticles and preparation method thereof

An iron oxide nanometer and particle technology, applied in iron oxide, iron oxide/iron hydroxide, nanotechnology, etc., can solve the problem of poor sample dispersibility and uniformity of morphology, harsh reaction conditions of high temperature pyrolysis, raw materials and reagents High toxicity and other problems, to achieve the effect of similar basic structural composition, enhanced signal intensity value, and uniform iron core size

Active Publication Date: 2020-11-20
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods also have obvious defects: the reaction conditions of the high temperature pyrolysis method are harsh, the raw materials and reagents used are highly toxic, and the product is not suitable for in vivo application; the sample prepared by hot injection co-precipitation has uniformity in dispersion and morphology Poor, imaging performance needs to be improved

Method used

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  • A kind of extremely small iron oxide nanoparticles and preparation method thereof
  • A kind of extremely small iron oxide nanoparticles and preparation method thereof
  • A kind of extremely small iron oxide nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Dissolve ferric chloride hexahydrate (600mg) and ferrous chloride tetrahydrate (221mg) in 100mL of purified water, mix them well and put them into a 250mL three-necked round-bottomed glass bottle (one port is blown into nitrogen, and the other port is for feeding) , one port for mechanical stirring). Heat in a water bath to rapidly raise the temperature of the solution to 90°C. Dilute concentrated ammonia water (about 28wt%, 900 μL) with purified water to 5 mL, and use a dual-channel micro-sampler to slowly add ammonia solution to the reaction solution at a rate of 100 μL / min at 90 °C with high-speed stirring (600 rpm) . After adding, stop the water bath heating and mechanical stirring, place the reaction vessel quickly in a cold water bath and low-frequency induction heating equipment (the low-frequency induction heating equipment model is GPH-26, the output power is 10KHz or 50KHz, purchased from Zhengzhou Rijia Electronics Co., Ltd. Co., Ltd.), the output current i...

Embodiment 2

[0038]Dissolve ferric chloride hexahydrate (100mg) and ferrous chloride tetrahydrate (46mg) in 200mL purified water, mix them well and put them into a 250mL three-necked round-bottomed glass bottle (one port is blown into nitrogen, and the other port is for feeding) , one port for mechanical stirring). Heat in a water bath to rapidly raise the temperature of the solution to 70°C. Dilute concentrated ammonia water (about 28wt%, 200 μL) with purified water to 5 mL, and use a dual-channel micro-sampler to slowly add ammonia solution to the reaction solution at a rate of 200 μL / min at 70 °C with high-speed stirring (600 rpm) . After the addition, stop the water bath heating and mechanical stirring, place the reaction vessel quickly in a cold water bath and low-frequency induction heating equipment (the low-frequency induction heating equipment model is SPG-10-II, the output power is 380KHz, purchased from Shenzhen Shuangping Power Supply Co., Ltd.), the output current is adjuste...

Embodiment 3

[0040] Dissolve ferric chloride hexahydrate (25 mg) and ferrous chloride tetrahydrate (10 mg) in 40 mL of purified water, mix them well, add them to a 50 mL plastic centrifuge tube, and mechanically stir while blowing nitrogen gas. Heat in a water bath to rapidly raise the temperature of the solution to 80°C. Concentrated ammonia water (about 28wt%, 50 μL) was diluted to 5 mL with purified water, and the ammonia solution was slowly added to the reaction solution at a rate of 150 μL / min at 80° C. with high-speed stirring (600 rpm) using a dual-channel microsampler. After the addition, stop the water bath heating and mechanical stirring, place the reaction vessel quickly in a cold water bath and low-frequency induction heating equipment (the model of the low-frequency induction heating equipment described is SPG-10-III, and the output power is 790KHz, purchased from Shenzhen Shuangping Power Supply Co., Ltd.), the output current is adjusted to 6A-2A, and the temperature of the s...

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Abstract

The invention discloses a tiny ferric oxide nanoparticle and a preparation method thereof. The preparation method comprises the following steps that (1) trivalent ferric salt and bivalent ferric saltare dissolved in water to be prepared into a water solution; heating is performed, so that the temperature of the water solution is raised; (2) an alkali water solution is added into the water solution obtained in the step (1); after the addition is completed, heating stops; a reaction system is put into an alternating magnetic field; (3) the reaction system is subjected to procedure temperature reduction in the alternating magnetic field; during the temperature reduction, high-molecular polymers are added; the alternating magnetic field is switched off; after the reaction solution is treated,the tiny ferric oxide nanoparticle is obtained. The effective uniform nucleation can be ensured; the rapid growth of the particle is limited; the tiny particle with uniform size is obtained; the intensity of the chemical exchange effect at the particle surface can be enhanced, so that the particle has excellent T1 magnetic resonance imaging performance; the T1 signal intensity relative to ferumoxytol is obviously enhanced.

Description

technical field [0001] The invention relates to a method for preparing iron oxide nanoparticles, in particular to a method for preparing extremely small iron oxide nanoparticles by using a cooling co-precipitation method combined with an alternating magnetic field. Background technique [0002] Traditional superparamagnetic iron oxide particles mainly exhibit T2-magnetic resonance imaging (MRI) enhancement effect, which achieves contrast effect by shortening the transverse relaxation time of water molecules and weakening the water signal intensity of surrounding tissues. Dark signals are easily confused with hemorrhage, calcification or metal decomposition in nearby areas, which will mislead clinical diagnosis to a certain extent. At the same time, the strong magnetism of iron oxide particles will disturb the magnetic field in local areas, making the image blurred, and there are many sensitivity and artifacts At the same time, traditional T1-MRI gadolinium agents used clinic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/06B82Y40/00A61B5/055
CPCA61B5/055B82Y40/00C01G49/06C01P2004/04C01P2004/64
Inventor 顾宁陈博郭占航
Owner SOUTHEAST UNIV