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Genistein composition and application thereof

A technology of genistein and composition, which is applied in drug combination, respiratory system diseases, organic chemistry, etc., to achieve the effect of increasing yield and eliminating mucosal swelling

Inactive Publication Date: 2018-11-23
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many medicines for the treatment of pharyngitis, they are all based on western medicine and supplemented by traditional Chinese medicine. In recent years, the curative effects of these medicines disclosed have not been able to meet the needs of the market and need to be further improved. More effective medicines are needed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The genistein composition is prepared by the following steps:

[0025] Step 1. Take the root of the mountain bean and grind it, grind it, sieve it, add the mixed solution and soak it for 48 hours, take it out, put it in a sealed container and treat it under the pressure of 120kPa for 2 hours, and let it drop to atmospheric pressure naturally, take it out and stir it in ethyl acetate 0.5h, filter, and place the filtered solid matter in a drum drier to dry to obtain the mountain bean root powder, wherein, in proportion by weight, the mixed solution consists of 1 part of citric acid aqueous solution with a mass fraction of 2%, 2 parts Dipotassium hydrogen phosphate aqueous solution with a mass fraction of 1%, 2 parts of an aqueous solution of methyl isomadizin with a mass fraction of 4%, 1 part of fatty alcohol polyoxyethylene ether sodium sulfate, 1 part of sodium lauryl sulfate, and 1 part of lignin sulfonate salt, 2 parts of sodium chloride, 50 parts of water;

[0026]...

Embodiment 2

[0030] The genistein composition is prepared by the following steps:

[0031] Step 1. Take the root of the mountain bean and grind it, grind it, sieve it, add the mixed solution and soak it for 48 hours, take it out, put it in a sealed container and treat it under the pressure of 120kPa for 2 hours, and let it drop to atmospheric pressure naturally, take it out and stir it in ethyl acetate 0.5h, filter, and place the filtered solid matter in a drum drier to dry to obtain the mountain bean root powder, wherein, in proportion by weight, the mixed solution consists of 1 part of citric acid aqueous solution with a mass fraction of 2%, 2 parts Dipotassium hydrogen phosphate aqueous solution with a mass fraction of 1%, 2 parts of an aqueous solution of methyl isomadizin with a mass fraction of 4%, 1 part of fatty alcohol polyoxyethylene ether sodium sulfate, 1 part of sodium lauryl sulfate, and 1 part of lignin sulfonate salt, 2 parts of sodium chloride, 50 parts of water;

[0032]...

Embodiment 3

[0036] The genistein composition is prepared by the following steps:

[0037]Step 1: Grind the bean root, grind it, sieve it, add the mixed liquid and soak it for 48 hours, take it out, put it in a sealed container and treat it under the pressure of 120KPa for 2 hours, then reduce it to atmospheric pressure naturally, take it out and stir it in ethyl acetate 0.5h, filter, and place the filtered solid matter in a drum drier to dry to obtain the mountain bean root powder, wherein, in proportion by weight, the mixed solution consists of 1 part of citric acid aqueous solution with a mass fraction of 2%, 2 parts Dipotassium hydrogen phosphate aqueous solution with a mass fraction of 1%, 2 parts of an aqueous solution of methyl isomadizin with a mass fraction of 4%, 1 part of fatty alcohol polyoxyethylene ether sodium sulfate, 1 part of sodium lauryl sulfate, and 1 part of lignin sulfonate salt, 2 parts of sodium chloride, 50 parts of water;

[0038] Step 2, add the aqueous ethanol...

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PUM

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Abstract

The invention discloses a genistein composition. The genistein composition is prepared by the following steps of step 1, selecting vietnamese sophora root, crushing, grinding into powder, screening, soaking, and drying, so as to obtain a vietnamese sophora powder; step 2, adding an aqueous solution of ethanol into the vietnamese sophora powder, extracting, collecting the extracting solution, sequentially concentrating, acidifying and extracting, selecting an organic layer, and concentrating, so as to obtain an extract; step 3, dissolving the extract by water, adding into macroporous adsorptionresin to adsorb, eluting by purified water, eluting by the aqueous solution of ethanol in a gradient way, collecting the eluting solution of ethanol, and concentrating, so as to obtain a concentratedsolution; step 4, adding the purified water into the concentrated solution, mixing, filtering by a film, obtaining filtrate, and concentrating by the film, so as to obtain the genistein composition.The invention also discloses application of the genistein composition. The genistein composition has good inhibiting effect on inflammation, and can be used for preparing the medicine for treating sphagitis.

Description

technical field [0001] The present invention relates to the field of medicine. More specifically, the present invention relates to a genistein composition and its application. Background technique [0002] Genistein is one of the main active factors in soybean isoflavones, the most effective functional ingredient in soybean isoflavone products, and has various physiological functions. Pharyngitis is a disease caused by bacteria, which can be divided into two types: acute pharyngitis and chronic pharyngitis. Due to incomplete treatment of acute pharyngitis and recurrent attacks, it becomes chronic, or due to various nasal diseases, nasal orifice blockage, long-term mouth breathing, physical and chemical factors, neck radiation therapy, etc. often stimulate the pharynx, Then the systemic symptoms are obvious, such as fever and fear of cold, headache, loss of appetite, and sore limbs. Chronic pharyngitis: It is mainly due to incomplete treatment of acute pharyngitis and repe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07D311/40A61P11/04
CPCA61P11/04C07D311/36C07D311/40
Inventor 缪剑华王硕欧春丽龚小妹周小雷吴玲玲闫炳雄宋志军姚彩云
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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