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Preparation method of a polymer scaffold with controllable degradation rate

A degradation rate and polymer technology, applied in the field of medical materials, can solve the problems of uncontrollable degradation rate of stents and accelerated degradation of polylactic acid.

Active Publication Date: 2021-04-16
陕西兴泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problem that the degradation product of the existing degradable polymer stent is acidic, which will accelerate the degradation of polylactic acid, resulting in an uncontrollable degradation rate of the stent, and provide a method for preparing a polymer stent with a controllable degradation rate

Method used

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  • Preparation method of a polymer scaffold with controllable degradation rate
  • Preparation method of a polymer scaffold with controllable degradation rate
  • Preparation method of a polymer scaffold with controllable degradation rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: (a) select the poly-L-lactic acid that molecular weight is 200,000 Da and the chitosan that molecular weight is 150,000 Da, pulverize 9 parts of poly-lactic acid and 1 part of chitosan respectively 25 microns, wherein, chitosan The degree of deacetylation is 96%. Add dimethyl sulfoxide solution in the reactor, and spray the powdered polylactic acid into the dimethyl sulfoxide solution of the reactor through a high-pressure nozzle and nitrogen together. Similarly, Spray the chitosan powder into the dimethyl sulfoxide solution system, and stir for 20 minutes by magnetic stirring to make the poly-L-lactic acid and chitosan evenly distributed. After the stirring is completed, immediately place the above solution system in the In an ultrasonic blender, ultrasonically blend for 30 minutes, freeze the above solution system at -60°C for 10 hours, raise the temperature of the partition of the freeze dryer to 10°C, dry the solution system at this temperature for 2 ho...

Embodiment 2

[0030] Embodiment 2: (a) select molecular weight to be 150,000 Da poly-L-lactic acid and molecular weight to be the chitosan of 80,000 Da, 9 parts of poly-L-lactic acid and 2 parts of chitosan are pulverized to 30 microns respectively, the chitosan The degree of deacetylation is 98%, and the dimethyl sulfoxide solution is added in the reactor, and the powdered polylactic acid is sprayed into the dimethyl sulfoxide solution of the reactor through a high-pressure nozzle and nitrogen, and the same, and then Spray the chitosan powder into the dimethyl sulfoxide solution system, and stir the chitosan by magnetic force for 30 minutes to make the poly-L-lactic acid and chitosan evenly distributed. The system was placed in an ultrasonic blender, ultrasonically blended for 40 minutes, the above solution system was frozen at -45°C for 15 hours, and the temperature of the partition of the freeze dryer was raised to 5°C, and the solution system was dried at this temperature for 4 hours to ...

Embodiment 3

[0034]Embodiment 3: (a) select the poly-L-lactic acid that molecular weight is 300,000 Da and the chitosan that molecular weight is 150,000 Da, pulverize 9 parts of poly-lactic acid and 5 parts of chitosan respectively to 38 microns, in reactor Add the dimethyl sulfoxide solution, and spray the powdered polylactic acid into the dimethyl sulfoxide solution of the reaction kettle through the high-pressure nozzle and nitrogen. Similarly, spray the chitosan powder into the dimethyl sulfoxide solution. In the sulfoxide solution system, stir for 20 minutes by magnetic stirring to make the poly-L-lactic acid and chitosan evenly distributed. After the stirring is completed, immediately place the above solution system in an ultrasonic blender and ultrasonically blend for 30 minutes. The above solution system was frozen at -20°C for 20 hours, and the temperature of the partition of the freeze dryer was raised to 0°C, and the solution system was dried at this temperature for 5 hours, and ...

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Abstract

The invention discloses a method for preparing a polymer scaffold with a controllable degradation rate, which comprises the following steps: (a) pulverizing poly-L-lactic acid and chitosan to a particle size of 25-38 microns, poly-L-lactic acid and chitosan Spray into the dimethyl sulfoxide solution system, stir evenly, ultrasonically blend for 30-40min, and freeze-dry the solution system after ultrasonic blending to obtain a blend; (b) pulverize the chitosan to a particle size of 25-38 microns, add the pulverized chitosan to the isopropanol solution with a mass fraction of 10-20% sodium oxide, stir evenly, add haloalkane drop by drop, carry out the alkylation reaction for 3-4h, and wash the alkane with diethyl ether Alkylated product, vacuum-dried to obtain alkylated chitosan; (c) adding the blend into a twin-screw extruder, extruding the blend pipe, and laser cutting the pipe, (d) adding step (b) The obtained alkylated chitosan is added into the acetone solution, and the drug to be loaded is dissolved in the acetone solution, ultrasonically atomized and pressed.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a polymer bracket with controllable degradation speed. Background technique [0002] The main component of degradable vascular stents is polylactic acid. The degradation of polylactic acid requires the participation of macrophages and the replacement of autologous tissue. The degradation rate of polylactic acid stents in the body can neither be degraded too fast nor too slow. To obtain effective support, the degradation is too slow, and the bracket stays in the body for a long time and cannot disappear in time. [0003] Patent CN201710121199.7 discloses a modified degradable scaffold and its preparation method. The composite material is formed by using high molecular weight L-polylactic acid, low molecular weight L-lactic acid and high molecular weight racemic polylactic acid as raw materials to form a tube , and then laser cut into ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/10A61L31/14A61L31/16
CPCA61L31/042A61L31/06A61L31/10A61L31/148A61L31/16A61L2300/606A61L2420/08C08L5/08C08L67/04
Inventor 邹雪王亮王刚陈果
Owner 陕西兴泰生物科技有限责任公司