Isopropyl nitrite preparation method

Abstract

The invention discloses an isopropyl nitrite preparation method. The method particularly comprises the following steps that isopropanol is added in a reaction vessel, sodium nitrite is added while stirring is conducted, the reaction temperature is controlled to range from 20 DEG C to 50 DEG C, a dilute sulfuric acid solution is dropwise added slowly, after dropwise adding is completed, a thermal reaction is conducted, separation is conducted, and isopropyl nitrite is obtained. The preparation method is simple in technology, the condition is easy to control, the production cost is low, the safety coefficient is high, convenience is brought to aftertreatment, and the method has very high operability and repeatability; according to the synthetic method, the product yield can reach 95% or above, industrial production is facilitated, and the problems that a traditional technology has difficulty in controlling the reaction condition and is high in production cost, low in yield and the like are solved.

Description

technical field [0001] The present invention relates to a kind of synthetic method, be specifically related to a kind of preparation method of isopropyl nitrite. It belongs to the technical field of organic synthesis. Background technique [0002] Isopropyl nitrite is a kind of nitrite, which has low stability, is easy to explode, and is difficult to store. It plays an important role in dilating blood vessels, lowering blood pressure and tachycardia. It is widely used in the fields of military, engineering technology and medicine. At the same time, isopropyl nitrite is a better diazotization reagent. [0003] The preparation method of traditional isopropyl nitrite has 3 kinds, and a kind of is by isopropanol-nitrosation method, uses isopropanol, sodium nitrite, sulfuric acid as raw material, reacts under methylene chloride solvent and makes, and Sulfuric acid is raw material, and the added value of by-product sodium sulfate is lower, and sulfuric acid concentration is with...

AI Technical Summary

Problems solved by technology

[0003] The preparation method of traditional isopropyl nitrite has 3 kinds, and a kind of is by isopropanol-nitrosation method, uses isopropanol, sodium nitrite, sulfuric acid as raw material, reacts under methylene chloride solvent and makes, and Sulfuric acid is raw material, and the added value of by-product sodium sulfate is lower, and sulfuric acid concentration is within 40%, and water consumption is bigger, and reaction yield is lower (84%); Silver nitrate is prepared as a raw material; not only the reaction yield is low (52%), but also the requirements for operating conditions are high, the amount of waste water is large, and the production cost is expensive; there is also a method to prepare by reacting benzophenone and isopropanol , but the by-product dimethyl ketone will be generated, and the reaction is not easy to control