Preparation method for mesoporous bioactive glass/sodium alginate-sodium alginate layered bone tissue engineering scaffold

A technology of bone tissue engineering and sodium alginate, applied in the field of materials science, can solve the problems of poor osteoconductivity, fast drug release, low mechanical strength, etc. Effect
CN108939162AActive Publication Date: 2018-12-07UNIV OF SHANGHAI FOR SCI & TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF SHANGHAI FOR SCI & TECH
Publication Date
2018-12-07

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Abstract

The invention provides a preparation method for mesoporous bioactive glass / sodium alginate-sodium alginate layered bone tissue engineering scaffold. The preparation method includes a step of preparingsodium alginate ink; a step of preparing mesoporous bioactive glass / sodium alginate composite ink; a step of designing the appearance and internal structure of a mesoporous bioactive glass / sodium alginate-sodium alginate layered bone tissue engineering scaffold; and a step of preparing the mesoporous bioactive glass / sodium alginate-sodium alginate layered bone tissue engineering scaffold by adopting a three-dimensional printing technology. Proved by cell experiment results, the prepared mesoporous bioactive glass / sodium alginate-sodium alginate layered scaffold has excellent capabilities of promoting proliferation and differentiation of human bone marrow mesenchymal stem cells (hBMSCs), and therefore, excellent biological activity can be shown.
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Description

technical field

[0001] The invention belongs to the field of materials science, and relates to a bone tissue engineering scaffold, in particular to a preparation method of a mesoporous bioglass / sodium alginate-sodium alginate layered bone tissue engineering scaffold. Background technique

[0002] At present, bone tissue defects caused by tumor resection, congenital diseases, infection and trauma are common clinical conditions. The use of bone tissue engineering scaffolds to repair the defect is considered to be one of the effective methods to solve related problems. Since a series of infection, inflammation and pain problems are easily caused after bone transplantation, it is difficult for a simple scaffold material to meet the requirements of an ideal bone repair material. If the drug can be loaded directly into the implant material and released in situ after implantation, the in situ release of the drug can not only prevent the metastasis and spread of diseased cells, but...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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