3D printed PCL-Mg bone tissue engineering scaffold and preparation method thereof

Abstract

The invention discloses a 3D printed PCL-Mg bone tissue engineering scaffold and a preparation method thereof. The 3D printed PCL-Mg bone tissue engineering scaffold is prepared from poly-epsilon-caprolactone PCL and magnesium chloride as raw materials through a 3D printing technology. After being implanted into the human body, PCL as a bioabsorbable material is gradually degraded and releases Mgto promote osteochondral generation. The porous structure of the scaffold can induce bone ingrowth and finally repair bone defects, tumors and bone defects after infection. The 3D printed PCL-Mg bonetissue engineering scaffold has the advantages of simple and reliable structure, controllable shape and microstructure, reliable mechanical property, controllable ion release performance, convenient implantation, small trauma and low cost.

Description

technical field [0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed PCL-Mg bone tissue engineering scaffold and a preparation method thereof. Background technique [0002] Clinically, bone defects caused by trauma, tumors, and infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especially for the treatme...

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high cost; 3. Various Artificial bone substitute materials made of metals, ceramics or polymers have been used clinically, but most of them are used as permanent implants. They cannot participate in the metabolism of the human body, so the long-term effect is often unsatisfactory

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